Imaging genetics of schizophrenia.

abstract：:Impairment of cognitive function is the central feature of dementia. Although, clinically, the cognitive deficit most often manifests itself as memory problems, a number of other areas of cognition are affected, and memory is but one of the cognitive skills compromised in dementia. Dementia with Lewy bodies, for examp...

journal_title：Dialogues in clinical neuroscience

authors： Wesnes KA,Harrison JE

更新日期：2003-03-01 00:00:00

abstract：:Epidemiological studies show that anxiety disorders are highly prevalent and an important cause of functional impairment; they constitute the most frequent menial disorders in the community. Phobias are the most common with the highest rates for simple phobia and agoraphobia. Panic disorder (PD) and obsessive-compulsi...

journal_title：Dialogues in clinical neuroscience

authors： Martin P

更新日期：2003-09-01 00:00:00

abstract：:Major depressive disorder (MDD) is a major public health concern. Despite tremendous advances, the pathogenic mechanisms associated with MDD are still unclear. Moreover, a significant number of MDD subjects do not respond to the currently available medication. MicroRNAs (miRNAs) are a class of small noncoding RNAs tha...

journal_title：Dialogues in clinical neuroscience

authors： Dwivedi Y

更新日期：2014-03-01 00:00:00

abstract：:The traditional categorical classification system and new diagnostic systems will be discussed in this issue.
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journal_title：Dialogues in clinical neuroscience

authors： Thibaut F

更新日期：2020-03-01 00:00:00

abstract：:There is mounting evidence that recurrent mood disorders - once considered "good prognosis diseases"- are, in fact, often very severe and life-threatening illnesses. Furthermore, although mood disorders have traditionally been conceptualized as neurochemical disorders, there is now evidence from a variety of sources d...

journal_title：Dialogues in clinical neuroscience

authors： Quiroz JA,Manji HK

更新日期：2002-03-01 00:00:00

abstract：:Wider use of pharmacological models would facilitate the development of new drugs for Alzheimer's disease (AD), The two main models currently used are based on the cholinergic and glutamatergic hypotheses of AD, Although they lead to some of the attention and memory impairment observed in AD, they do not fully reprodu...

journal_title：Dialogues in clinical neuroscience

authors： Gilles C,Ertlé S

更新日期：2000-09-01 00:00:00

abstract：:Alcohol dependence (alcoholism) is a complex disorder attributed to the interaction of genetic and environmental factors that form a collage of "disease" predisposition, which is not identical for every alcohol-dependent individual. There is considerable evidence to demonstrate that genetic predisposition accounts for...

journal_title：Dialogues in clinical neuroscience

authors： Hines LM,Ray L,Hutchison K,Tabakoff B

更新日期：2005-01-01 00:00:00

abstract：:Several structural deviances in the brain in "endogenous psychoses" have been described over the last decades. The enlargement of the lateral ventricles and the subtle structural deficits in temporobasal and orbital frontal structures (hypofrontality) are reasonably well established in the majority of schizophrenic pa...

journal_title：Dialogues in clinical neuroscience

authors： Beckmann H,Jakob H,Senitz D

更新日期：2006-01-01 00:00:00

abstract：:Biomarkers have been receiving increasing attention, especially in the field of psychiatry In contrast to the availability of potent therapeutic tools including pharmacotherapy, psychotherapy, and biological therapies, unmet needs remain in terms of onset of action, stability of response, and further improvement of th...

journal_title：Dialogues in clinical neuroscience

authors： Wiedemann K

更新日期：2011-01-01 00:00:00

abstract：:Anxiety comprises many clinical descriptions and phenotypes. A genetic predisposition to anxiety is undoubted; however, the nature and extent of that contribution is still unclear. Methods for the genetic analysis of such complex disorders is briefly reviewed, followed by a discussion of the comorbidity of anxiety wit...

journal_title：Dialogues in clinical neuroscience

authors： Morris-Rosendahl DJ

更新日期：2002-09-01 00:00:00

abstract：:Caffeine is not considered addictive, and in animals it does not trigger metabolic increases or dopamine release in brain areas involved in reinforcement and reward. Our objective was to measure caffeine effects on cerebral perfusion in humans using single photon emission computed tomography with a specific focus on a...

journal_title：Dialogues in clinical neuroscience

authors： Nehlig A,Armspach JP,Namer IJ

更新日期：2010-01-01 00:00:00

abstract：:Recent research has overcome the old paradigms of the brain as an immunologically privileged organ, and of the exclusive role of neurotransmitters and neuropeptides as signal transducers in the central nervous system. Growing evidence suggests that the signal proteins of the immune system - the cytokines - are also in...

journal_title：Dialogues in clinical neuroscience

authors： Schwarz MJ

更新日期：2003-06-01 00:00:00

abstract：:Despite pharmacologic advances, the treatment of schizophrenia remains a challenge, and suboptimal outcomes are still all too frequent. Although treatment goals of response, remission, and recovery have been defined more uniformly, a good "effectiveness" measure mapping onto functional outcomes is still lacking. Moreo...

journal_title：Dialogues in clinical neuroscience

authors： Kane JM,Correll CU

更新日期：2010-01-01 00:00:00

abstract：:Development of the characteristics of social phobia often requires a diathesis in the form of a temperamental bias. A behavioral profile marked by vigorous motor activity and crying to unfamiliar stimuli at 4 months of age - called high reactivity- is characteristic of about 20% of healthy, Caucasian infants. This pat...

journal_title：Dialogues in clinical neuroscience

authors： Kagan J

更新日期：2002-09-01 00:00:00

abstract：:Understanding individual response to a drug-what determines its efficacy and tolerability-is the major bottleneck in current drug development and clinical trials. Intracellular response and metabolism, for example through cytochrome P-450 enzymes, may either enhance or decrease the effect of different drugs, dependent...

journal_title：Dialogues in clinical neuroscience

authors： Herwig R,Lehrach H

更新日期：2006-01-01 00:00:00

abstract：:With his early publications (1910-1913), Karl Jaspers created a comprehensive methodological arsenal for psychiatry, thus laying the foundation for descriptive psychopathology. Following Edmund Husserl, the founder of philosophical phenomenology, Jaspers introduced phenomenology into psychopathology as "static underst...

journal_title：Dialogues in clinical neuroscience

authors： Häfner H

更新日期：2015-03-01 00:00:00

abstract：:As one of the most common neurological disorders, epilepsy has devastating behavioral, social, and occupational consequences and is associated with accumulating brain damage and neurological deficits. Epilepsy comprises a large number of syndromes, which vary greatly with respect to their etiology and clinical feature...

journal_title：Dialogues in clinical neuroscience

authors： Beck H,Elger CE

更新日期：2008-01-01 00:00:00

abstract：:Schizophrenia is still a condition with obscure causes and psychopathology. This paper aims to discuss the "disconnectivity" hypothesis in relation to some neurological conditions which are known to alter brain connectivity, as well as mimicking some aspects of the disorder. After a short historical introduction to th...

journal_title：Dialogues in clinical neuroscience

authors： Foucher JR,Luck D

更新日期：2006-01-01 00:00:00

abstract：:Illustrating the complexity of the stress response and its multifaceted manifestations is the leading idea of this overview of experimental paradigms used for stress induction in laboratory animals. The description of key features of models based on naturalistic stressors, pharmacological challenges, and genomic manip...

journal_title：Dialogues in clinical neuroscience

authors： Patchev VK,Patchev AV

更新日期：2006-01-01 00:00:00

abstract：:Psychiatric disorders are complex multifactorial disorders involving chronic alterations in neural circuit structure and function. While genetic factors play a role in the etiology of disorders such as depression, addiction, and schizophrenia, relatively high rates of discordance among identical twins clearly point to...

journal_title：Dialogues in clinical neuroscience

authors： Bagot RC,Labonté B,Peña CJ,Nestler EJ

更新日期：2014-09-01 00:00:00

abstract：:Emotional processes are central to behavior, yet their deeply subjective nature has been a challenge for neuroscientific study as well as for psychiatric diagnosis. Here we explore the relationships between subjective feelings and their underlying brain circuits from a computational perspective. We apply recent insigh...

journal_title：Dialogues in clinical neuroscience

authors： Kepecs A,Mensh BD

更新日期：2015-12-01 00:00:00

abstract：:This overview will outline the current results of neuroscience research on the possible effects of digital media use on the human brain, cognition, and behavior. This is of importance due to the significant amount of time that individuals spend using digital media. Despite several positive aspects of digital media, wh...

journal_title：Dialogues in clinical neuroscience

authors： Korte M

更新日期：2020-06-01 00:00:00

abstract：:The introduction of biological markers in the clinical management of Alzheimer's disease (AD) will not only improve diagnosis relating to early detection of neuropathology with underlying molecular mechanisms, but also provides tools for the assessment of objective treatment benefits. In this review, we identify a num...

journal_title：Dialogues in clinical neuroscience

authors： Hampel H,Broich K,Hoessler Y,Pantel J

更新日期：2009-01-01 00:00:00

abstract：:The links between late-life depression and the medical comorbidities that are often associated with it can be divided into two paths. The path from medical illness to depression reflects general mechanisms related to stress, disability, and loss, as well as more specific physiological mechanisms, including those relat...

journal_title：Dialogues in clinical neuroscience

authors： Katz IR

更新日期：1999-09-01 00:00:00

abstract：:Time has long been a major topic of study in social science, as in other sciences or in philosophy. Social scientists have tended to focus on collective representations of time, and on the ways in which these representations shape our everyday experiences. This contribution addresses work from such disciplines as anth...

journal_title：Dialogues in clinical neuroscience

authors： Schulz Y

更新日期：2012-12-01 00:00:00

abstract：:There is increasing knowledge about considerable comorbidity between psychiatric and somatic diseases, questioning whether variations in genes could be predisposing factors for both conditions. With respect to the multiple interactions between brain and body investigations have centered on variants in several candidat...

journal_title：Dialogues in clinical neuroscience

authors： Bondy B

更新日期：2003-06-01 00:00:00

abstract：:Over the last few years, neuroimaging techniques have contributed greatly to the identification of the structural and functional neuroanatomy of anxiety disorders. The amygdala seems to be a crucial structure for fear and anxiety, and has consistently been found to be activated in anxiety-provoking situations. Apart f...

journal_title：Dialogues in clinical neuroscience

authors： Holzschneider K,Mulert C

更新日期：2011-01-01 00:00:00

abstract：:Despite the fact that 50 years have passed since the Nazi regime and the Holocaust the psychic sequelae are far from being overcome. The majority of Holocaust survivors and World War II veterans still list their experiences as the "most significant stressors" of their lives. The literature provides ample evidence that...

journal_title：Dialogues in clinical neuroscience

authors： Barak Y,Szor H

更新日期：2000-03-01 00:00:00

abstract：:Hypersomnia, a complaint of excessive daytime sleep or sleepiness, affects 4% to 6% of the population, with an impact on the everyday life of the patient Methodological tools to explore sleep and wakefulness (interview, questionnaires, sleep diary, polysomnography, Multiple Sleep Latency Test, Maintenance of Wakefulne...

journal_title：Dialogues in clinical neuroscience

authors： Dauvilliers Y,Buguet A

更新日期：2005-01-01 00:00:00

abstract：:An evidence-based review of nonpharmacological treatments for anxiety disorders is presented. The vast majority of the controlled research is devoted to cognitive behavior therapy (CBT) and shows its efficiency and effectiveness in all the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) ...

journal_title：Dialogues in clinical neuroscience

authors： Cottraux J

更新日期：2002-09-01 00:00:00