Abstract：
:Hypersomnia, a complaint of excessive daytime sleep or sleepiness, affects 4% to 6% of the population, with an impact on the everyday life of the patient Methodological tools to explore sleep and wakefulness (interview, questionnaires, sleep diary, polysomnography, Multiple Sleep Latency Test, Maintenance of Wakefulness Test) and psychomotor tests (for example, psychomotor vigilance task and Oxford Sleep Resistance or Osler Test) help distinguish between the causes of hypersomnia. In this article, the causes of hypersomnia are detailed following the conventional classification of hypersomnic syndromes: narcolepsy, idiopathic hypersomnia, recurrent hypersomnia, insufficient sleep syndrome, medication- and toxin-dependent sleepiness, hypersomnia associated with psychiatric disorders, hypersomnia associated with neurological disorders, posttraumatic hypersomnia, infection (with a special emphasis on the differences between bacterial and viral diseases compared with parasitic diseases, such as sleeping sickness) and hypersomnia, hypersomnia associated with metabolic or endocrine diseases, breathing-related sleep disorders and sleep apnea syndromes, and periodic limb movements in sleep.
journal_name
Dialogues Clin Neuroscijournal_title
Dialogues in clinical neuroscienceauthors
Dauvilliers Y,Buguet Asubject
Has Abstractpub_date
2005-01-01 00:00:00pages
347-56issue
4eissn
1294-8322issn
1958-5969journal_volume
7pub_type
杂志文章,评审abstract：:Caffeine is not considered addictive, and in animals it does not trigger metabolic increases or dopamine release in brain areas involved in reinforcement and reward. Our objective was to measure caffeine effects on cerebral perfusion in humans using single photon emission computed tomography with a specific focus on a...
journal_title：Dialogues in clinical neuroscience
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2010-01-01 00:00:00
abstract：:Decision making has been extensively studied in the context of economics and from a group perspective, but still little is known on individual decision making. Here we discuss the different cognitive processes involved in decision making and its associated neural substrates. The putative conductors in decision making ...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2016-03-01 00:00:00
abstract：:In 2003, we proposed the hypersystemizing theory of autism. The theory proposes that the human mind possesses a systemizing mechanism (SM) that helps identify lawful regularities (often causal) that govern the input-operation-output workings of a system. The SM can be tuned to different levels, from low to high, with ...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2017-12-01 00:00:00
abstract：:Contemporary biological psychiatry uses experimental animal models to increase our understanding of affective disorder pathogenesis. Modern anxiolytic drug discovery mainly targets specific pathways and molecular determinants within a single phenotypic domain. However, greater understanding of the mechanisms of action...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2015-09-01 00:00:00
abstract：:Schizophrenia (SZ) and bipolar disorder (BPD) patients show a downregulation of GAD67, reelin (RELN), brain-derived neurotrophic factor (BDNF), and other genes expressed in telencephalic GABAergic and glutamatergic neurons. This downregulation is associated with the enrichment of 5-methylcytosine and 5-hydroxymethylcy...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2014-09-01 00:00:00
abstract：:Brain plasticity is an intrinsic characteristic of the nervous system that allows continuous remodeling of brain functions in pathophysiological conditions. Although normal aging is associated with morphological modifications and decline of cerebral functions, brain plasticity is at least partially preserved in elderl...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2013-03-01 00:00:00
abstract：:Studies over the last decade have transformed our previously simplistic view of microbes, having only a pathogenic role in disease to a more robust understanding that they are critical for maintaining human health. Indeed, our microbiota-the collection of commensal organisms that live in and on each of us-contributes ...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2019-01-01 00:00:00
abstract：:We now appreciate that estrogen is a pleiotropic gonadal steroid that exerts profound effects on the plasticity and cell survival of the adult brain. Over the past century, the life span of women has increased, but the age of the menopause remains constant. This means that women may now live over one third of their li...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2002-06-01 00:00:00
abstract：:Patients with cancer and depression experience more physical symptoms, have poorer quality of life, and are more likely to have suicidal thoughts or a desire for hastened death than are cancer patients who are not depressed. Despite the ubiquity of depressive symptoms in cancer patients at the end of life, critical qu...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：:The insights of ethology-the science of animal behavior from a biological and psychological point of view-were incorporated in the 1950s by the British developmental psychiatrist, John Bowlby, into his attachment theory, which argued that a secure affective base in infancy was critical to the normal development of per...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
abstract：:The links between late-life depression and the medical comorbidities that are often associated with it can be divided into two paths. The path from medical illness to depression reflects general mechanisms related to stress, disability, and loss, as well as more specific physiological mechanisms, including those relat...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:Treatment of Parkinson's disease (PD) is complex and often involves addressing behavioral changes in addition to the movement disorder. Patients with PD are susceptible to any psychiatric condition seen in the general population; some disorders, such as depression and anxiety, may result from PD-related neuropathologi...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
abstract：:Technology in genetics and brain imaging has advanced so rapidly that it is difficult to be knowledgeable about all the new tools being used in the pursuit of progress toward understanding and treating mental illness. While findings from new studies remain promising, caution is needed with regard to their current appl...
journal_title：Dialogues in clinical neuroscience
pub_type： 社论
doi：
更新日期：2014-12-01 00:00:00
abstract：:Depressive disorders are a leading cause of disability worldwide and greatly impact morbidity, health care utilization, and medical costs. Major depression that does not resolve with adequate antidepressant treatment is termed treatment-resistant depression (TRD), There is no universally accepted definition of TRD and...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2004-03-01 00:00:00
abstract：:Development of the characteristics of social phobia often requires a diathesis in the form of a temperamental bias. A behavioral profile marked by vigorous motor activity and crying to unfamiliar stimuli at 4 months of age - called high reactivity- is characteristic of about 20% of healthy, Caucasian infants. This pat...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：:A wide range of Internet interventions, mostly grounded in methods of cognitive behavioral therapy, have been developed and tested for several mental disorders. The evidence to date shows that these interventions are effective in reducing symptoms of depression. Metaanalyses report small-to-medium effect sizes when In...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2016-06-01 00:00:00
abstract：:Accumulating evidence suggests that psychotropic agents such as mood stabilizers, antidepressants, and antipsychotics realize their neurotrophic/neuroprotective effects by activating the mitogen activated protein kinase/extracellular signal-related kinase, PI3-kinase, and wingless/glycogen synthase kinase (GSK) 3 sign...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2009-01-01 00:00:00
abstract：:It is clinically important to recognize both bipolar disorder and borderline personality disorder (BPD) in patients seeking treatment for depression, and it is important to distinguish between the two. Research considering whether BPD should be considered part of a bipolar spectrum reaches differing conclusions. We re...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2013-06-01 00:00:00
abstract：:The study of molecular clock mechanisms in psychiatric disorders is gaining significant interest due to data suggesting that a misalignment between the endogenous circadian system and the sleep-wake cycle might contribute to the clinical status of patients suffering from a variety of psychiatric disorders. Sleep distu...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：:The introduction of biological markers in the clinical management of Alzheimer's disease (AD) will not only improve diagnosis relating to early detection of neuropathology with underlying molecular mechanisms, but also provides tools for the assessment of objective treatment benefits. In this review, we identify a num...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2009-01-01 00:00:00
abstract：:The current clinical use of psychotropic drugs is transnosologically oriented. This is facilitated by the current classification of mental disorders (International Classification of Diseases, 10th Revision [ICD-10]) and is perhaps justified if depression and psychosis (taken here as examples) are considered as being c...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：:As one of the most common neurological disorders, epilepsy has devastating behavioral, social, and occupational consequences and is associated with accumulating brain damage and neurological deficits. Epilepsy comprises a large number of syndromes, which vary greatly with respect to their etiology and clinical feature...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2008-01-01 00:00:00
abstract：:Losing a loved to suicide is one is one of life's most painful experiences. The feelings of loss, sadness, and loneliness experienced after any death of a loved one are often magnified in suicide survivors by feelings of quilt, confusion, rejection, shame, anger, and the effects of stigma and trauma. Furthermore, surv...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2012-06-01 00:00:00
abstract：:Despite the fact that 50 years have passed since the Nazi regime and the Holocaust the psychic sequelae are far from being overcome. The majority of Holocaust survivors and World War II veterans still list their experiences as the "most significant stressors" of their lives. The literature provides ample evidence that...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：:Recent years have seen an explosive growth of interest in the application of imaging genetics to understand neurogenetic mechanisms of schizophrenia. Imaging genetics applies structural and functional neuroimaging to study subjects carrying genetic risk variants that relate to a psychiatric disorder. We review selecte...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
abstract：:The first generation of antipsychotic drugs was discovered in the 1960s and 1970s, These agents were effective in treating psychosis, but were accompanied by significant side effects, including severe parkinsonism and akathisia. Second-generation antipsychotics were introduced in the 1990s, These drugs have at least e...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：:Anxiety comprises many clinical descriptions and phenotypes. A genetic predisposition to anxiety is undoubted; however, the nature and extent of that contribution is still unclear. Methods for the genetic analysis of such complex disorders is briefly reviewed, followed by a discussion of the comorbidity of anxiety wit...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：:The recognition that there are fundamental biological sex differences that extend beyond those that define sexual behavior and reproductive function has inspired the drive toward inclusion of both sexes in research design. This is supported by an underlying clinical rationale that studying both sexes is necessary to e...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2016-12-01 00:00:00
abstract：:Epidemiological studies show that anxiety disorders are highly prevalent and an important cause of functional impairment; they constitute the most frequent menial disorders in the community. Phobias are the most common with the highest rates for simple phobia and agoraphobia. Panic disorder (PD) and obsessive-compulsi...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：:Pharmacogenomic developments hold promise for personalized medicine in psychiatry with adjusted therapeutic doses, predictable responses, reduced adverse drug reactions, early diagnosis, and personal health planning. The prospects are exciting, but at the same time, these new techniques stand faced with important scie...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2009-01-01 00:00:00
