Abstract:
:The first generation of antipsychotic drugs was discovered in the 1960s and 1970s, These agents were effective in treating psychosis, but were accompanied by significant side effects, including severe parkinsonism and akathisia. Second-generation antipsychotics were introduced in the 1990s, These drugs have at least equal efficacy to their predecessors, but far fewer side effects. Some data suggest a broader efficacy profile. Clozapine remains the only superior antipsychotic in terms of the magnitude of psychotic symptom reduction. Clinical and animal studies are consistent in suggesting that the antipsychotic component of antidopaminergic treatments is initiated by dopamine receptor blockade in the striatum and that the signal is transmitted to the neocortex through the established basal ganglia-thalamo-cortical neuronal circuits. Other neurotransmitter actions (eg, antiserotonergic) can be exerted locally, in the neocortex. Defining tissue targets of drug action may suggest additional strategies for developing new antipsychotic drugs.
journal_name
Dialogues Clin Neuroscijournal_title
Dialogues in clinical neuroscienceauthors
Tamminga CAsubject
Has Abstractpub_date
2000-09-01 00:00:00pages
281-6issue
3eissn
1294-8322issn
1958-5969journal_volume
2pub_type
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journal_title:Dialogues in clinical neuroscience
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2010-01-01 00:00:00
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更新日期:2015-12-01 00:00:00
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pub_type: 社论
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更新日期:2014-12-01 00:00:00
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
doi:
更新日期:2002-09-01 00:00:00
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2006-01-01 00:00:00
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
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更新日期:2015-09-01 00:00:00
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2008-01-01 00:00:00
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
doi:
更新日期:2002-06-01 00:00:00
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2015-06-01 00:00:00
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2006-01-01 00:00:00
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2009-01-01 00:00:00
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2012-09-01 00:00:00
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2010-01-01 00:00:00
abstract::Major depressive disorder (MDD) is a major public health concern. Despite tremendous advances, the pathogenic mechanisms associated with MDD are still unclear. Moreover, a significant number of MDD subjects do not respond to the currently available medication. MicroRNAs (miRNAs) are a class of small noncoding RNAs tha...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2014-03-01 00:00:00
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2009-01-01 00:00:00
abstract::In 2003, we proposed the hypersystemizing theory of autism. The theory proposes that the human mind possesses a systemizing mechanism (SM) that helps identify lawful regularities (often causal) that govern the input-operation-output workings of a system. The SM can be tuned to different levels, from low to high, with ...
journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2017-12-01 00:00:00
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journal_title:Dialogues in clinical neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2008-01-01 00:00:00