Abstract：
:We carried out two studies to test the hypothesis that altered central serotonergic function, as assessed by lower prolactin (PRL) response to fenfluramine (D-FEN), is more closely associated with suicidal behavior than a particular psychiatric diagnosis. A D-FEN test was performed in 85 major depressed inpatients, 33 schizophrenic inpatients, and 18 healthy controls. We showed that PRL response to D-FEN is a marker of suicidality, regardless of psychiatric disorder. We then examined the association en the serotonin (5-hydroxytryptamine) receptor 5-HT(2A) gene polymorphism (T102C) and suicide in a sample of Brazilian psychiatric inpatients (95 with schizophrenia, 78 with major depression) and 52 healthy controls. No differences were found in genotypic frequencies across patients and controls. Overall, no differences were found between patients with (n=66) and without (n=107) a history of suicide attempt. We also compared patients with a history of severe suicide attempts (lethality>3; n=32) and patients without such a history (n=107), but they did not exhibit different genotypic frequencies either. These results show thai the 5-HT(2A) gene polymorphism (T102C) may not be involved in the genetic susceptibility to suicidal behavior.
journal_name
Dialogues Clin Neuroscijournal_title
Dialogues in clinical neuroscienceauthors
Corrêa H,Romano-Silva MA,Duval F,Campi-Azevedo AC,Lima V,Macher JPsubject
Has Abstractpub_date
2002-12-01 00:00:00pages
408-16issue
4eissn
1294-8322issn
1958-5969journal_volume
4pub_type
杂志文章abstract：:As one of the most common neurological disorders, epilepsy has devastating behavioral, social, and occupational consequences and is associated with accumulating brain damage and neurological deficits. Epilepsy comprises a large number of syndromes, which vary greatly with respect to their etiology and clinical feature...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
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更新日期：2008-01-01 00:00:00
abstract：:The links between late-life depression and the medical comorbidities that are often associated with it can be divided into two paths. The path from medical illness to depression reflects general mechanisms related to stress, disability, and loss, as well as more specific physiological mechanisms, including those relat...
journal_title：Dialogues in clinical neuroscience
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更新日期：1999-09-01 00:00:00
abstract：:Technology in genetics and brain imaging has advanced so rapidly that it is difficult to be knowledgeable about all the new tools being used in the pursuit of progress toward understanding and treating mental illness. While findings from new studies remain promising, caution is needed with regard to their current appl...
journal_title：Dialogues in clinical neuroscience
pub_type： 社论
doi：
更新日期：2014-12-01 00:00:00
abstract：:A wide range of Internet interventions, mostly grounded in methods of cognitive behavioral therapy, have been developed and tested for several mental disorders. The evidence to date shows that these interventions are effective in reducing symptoms of depression. Metaanalyses report small-to-medium effect sizes when In...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2016-06-01 00:00:00
abstract：:Schizophrenia is still a condition with obscure causes and psychopathology. This paper aims to discuss the "disconnectivity" hypothesis in relation to some neurological conditions which are known to alter brain connectivity, as well as mimicking some aspects of the disorder. After a short historical introduction to th...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2006-01-01 00:00:00
abstract：:Over the last few years, neuroimaging techniques have contributed greatly to the identification of the structural and functional neuroanatomy of anxiety disorders. The amygdala seems to be a crucial structure for fear and anxiety, and has consistently been found to be activated in anxiety-provoking situations. Apart f...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
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更新日期：2011-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2006-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,meta分析,评审
doi：10.31887/DCNS.2019.21.3/aschmitt
更新日期：2019-09-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2010-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2019-03-01 00:00:00
abstract：:Recent years have seen an explosive growth of interest in the application of imaging genetics to understand neurogenetic mechanisms of schizophrenia. Imaging genetics applies structural and functional neuroimaging to study subjects carrying genetic risk variants that relate to a psychiatric disorder. We review selecte...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
abstract：:There is increasing knowledge about considerable comorbidity between psychiatric and somatic diseases, questioning whether variations in genes could be predisposing factors for both conditions. With respect to the multiple interactions between brain and body investigations have centered on variants in several candidat...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2003-06-01 00:00:00
abstract：:Contemporary biological psychiatry uses experimental animal models to increase our understanding of affective disorder pathogenesis. Modern anxiolytic drug discovery mainly targets specific pathways and molecular determinants within a single phenotypic domain. However, greater understanding of the mechanisms of action...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2015-09-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2008-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：:Human memory is not a literal reproduction of the past, but instead relies on constructive processes that are sometimes prone to error and distortion. Understanding of constructive memory has accelerated during recent years as a result of research that has linked together its cognitive and neural bases. This article f...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2012-03-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2014-09-01 00:00:00
abstract：:Obsessive-compulsive disorder (OCD) is a serious psychiatric disorder that affects approximately 2% of the populations of children and adults. Family aggregation studies have demonstrated that OCD is familial, and results from twin studies demonstrate that the familiality is due in part to genetic factors. Only three ...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
abstract：:The recognition that there are fundamental biological sex differences that extend beyond those that define sexual behavior and reproductive function has inspired the drive toward inclusion of both sexes in research design. This is supported by an underlying clinical rationale that studying both sexes is necessary to e...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2016-12-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2012-09-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2006-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
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doi：
更新日期：2013-09-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2003-06-01 00:00:00
abstract：:Illustrating the complexity of the stress response and its multifaceted manifestations is the leading idea of this overview of experimental paradigms used for stress induction in laboratory animals. The description of key features of models based on naturalistic stressors, pharmacological challenges, and genomic manip...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2006-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2013-12-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2006-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
