Abstract：
:Mental disorders represent a significant public health burden worldwide due to their high prevalence, chronically disabling nature, and substantial impact on quality of life. Despite growing knowledge of the pathological mechanisms that underlie the development of these disorders, a high percentage of patients do not respond to first-line clinical treatments; thus, there is a strong need for alternative therapeutic approaches. During the past half-century, after the identification of the endocannabinoid system and its role in multiple physiological processes, both natural and synthetic cannabinoids have attracted considerable interest as putative medications in pathological conditions such as, but not exclusive to, mental disorders. Here, we provide a summary of cannabinoid effects in support of possible therapeutic applications for major depression, bipolar disorder, anxiety, posttraumatic stress disorder, and schizophrenia. Considering this evidence, highlighted benefits and risks of cannabinoid use in the management of these illnesses require further experimental study. . :Los trastornos mentales representan una carga importante para la salud pública en todo el mundo debido a su alta prevalencia, su naturaleza crónica con discapacidad y su impacto significativo en la calidad de vida. A pesar del creciente conocimiento de los mecanismos patológicos que subyacen al desarrollo de estos trastornos, un alto porcentaje de pacientes no responde a los tratamientos clínicos de primera línea; por lo que existe una gran necesidad de enfoques terapéuticos alternativos. Durante los últimos cincuenta años, después de la identificación del sistema endocannabinoide y su papel en múltiples procesos fisiológicos, tanto los cannabinoides naturales como los sintéticos han concentrado un alto interés como posibles fármacos para trastornos mentales y otras patologías. En este artículo se resumen los efectos de los cannabinoides en apoyo de posibles aplicaciones terapéuticas para la depresión mayor, el trastorno bipolar, la ansiedad, el trastorno por estrés postraumático y la esquizofrenia. Teniendo en cuenta esta evidencia, el destacar tanto los riesgos como los beneficios del empleo de los cannabinoides en el tratamiento de estas enfermedades requiere de más trabajo experimental. :La prévalence élevée des troubles mentaux, leur chronicité et leur impact important sur la qualité de vie pèsent significativement sur la santé publique mondiale. La connaissance des mécanismes pathologiques qui sous-tendent ces troubles a progressé mais, un pourcentage élevé de patients ne répondant pas aux traitements de première ligne, d’autres approches thérapeutiques sont indispensables. L’étude du système endocannabinoïde et la mise en évidence de son rôle dans de multiples processus physiologiques au cours des cinquante dernières années, ont fortement attiré l’attention sur les cannabinoïdes naturels et synthétiques en tant que médicaments potentiels dans certaines pathologies comme, entre autres, les troubles mentaux. Nous résumons dans cet article les effets cannabinoϊdes qui pourraient s’inscrire dans le traitement de la dépression majeure, des troubles bipolaires, de l’anxiété, de l’état de stress post-traumatique et de la schizophrénie. Ces arguments nous incitent à explorer davantage les avantages et les risques des cannabinoïdes dans la prise en charge de ces maladies.
journal_name
Dialogues Clin Neuroscijournal_title
Dialogues in clinical neuroscienceauthors
Scherma M,Muntoni AL,Riedel G,Fratta W,Fadda Pdoi
10.31887/DCNS.2020.22.3/pfaddasubject
Has Abstractpub_date
2020-09-01 00:00:00pages
271-279issue
3eissn
1294-8322issn
1958-5969journal_volume
22pub_type
杂志文章abstract：:Biomarkers have been receiving increasing attention, especially in the field of psychiatry In contrast to the availability of potent therapeutic tools including pharmacotherapy, psychotherapy, and biological therapies, unmet needs remain in terms of onset of action, stability of response, and further improvement of th...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：:Psychiatric disorders are complex multifactorial disorders involving chronic alterations in neural circuit structure and function. While genetic factors play a role in the etiology of disorders such as depression, addiction, and schizophrenia, relatively high rates of discordance among identical twins clearly point to...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2014-09-01 00:00:00
abstract：:Sleep disorders in children and adolescents is a topic that has been, and remains, neglected in both public health education and professional training. Although much knowledge has been accumulated in recent times, it has been poorly disseminated and, therefore, relatively little is put into practice. Only some general...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2009-01-01 00:00:00
abstract：:We review critical trends in imaging genetics as applied to schizophrenia research, and then discuss some future directions of the field. A plethora of imaging genetics studies have investigated the impact of genetic variation on brain function, since the paradigm of a neuroimaging intermediate phenotype for schizophr...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2013-09-01 00:00:00
abstract：:The links between late-life depression and the medical comorbidities that are often associated with it can be divided into two paths. The path from medical illness to depression reflects general mechanisms related to stress, disability, and loss, as well as more specific physiological mechanisms, including those relat...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:With his early publications (1910-1913), Karl Jaspers created a comprehensive methodological arsenal for psychiatry, thus laying the foundation for descriptive psychopathology. Following Edmund Husserl, the founder of philosophical phenomenology, Jaspers introduced phenomenology into psychopathology as "static underst...
journal_title：Dialogues in clinical neuroscience
pub_type： 传,历史文章,杂志文章
doi：
更新日期：2015-03-01 00:00:00
abstract：:The insights of ethology-the science of animal behavior from a biological and psychological point of view-were incorporated in the 1950s by the British developmental psychiatrist, John Bowlby, into his attachment theory, which argued that a secure affective base in infancy was critical to the normal development of per...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：:There is mounting evidence that recurrent mood disorders - once considered "good prognosis diseases"- are, in fact, often very severe and life-threatening illnesses. Furthermore, although mood disorders have traditionally been conceptualized as neurochemical disorders, there is now evidence from a variety of sources d...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:Post-traumatic stress disorder (PTSD) may be associated with long-lasting psychological suffering, distressing psychosocial disability, markedly reduced health-related quality of life, and increased morbidity and mortality in a subgroup of individuals in the aftermath of serious traumatic events. Both etiopathogenesis...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2014-06-01 00:00:00
abstract：:Treatment of Parkinson's disease (PD) is complex and often involves addressing behavioral changes in addition to the movement disorder. Patients with PD are susceptible to any psychiatric condition seen in the general population; some disorders, such as depression and anxiety, may result from PD-related neuropathologi...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
abstract：:The study of molecular clock mechanisms in psychiatric disorders is gaining significant interest due to data suggesting that a misalignment between the endogenous circadian system and the sleep-wake cycle might contribute to the clinical status of patients suffering from a variety of psychiatric disorders. Sleep distu...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：:Alcohol dependence is a frequent, chronic, relapsing, and incurable disease with enormous societal costs. Thus, alcoholism therapy and research into its outcome are of major importance for public health. The present article will: (i) give a brief overview of the epidemiology, pathogenesis, and treatment outcomes of al...
journal_title：Dialogues in clinical neuroscience
pub_type： 临床试验,杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:This review serves as a systematic guide to the genetics of generalized anxiety disorder (GAD) and further focuses on anxiety-relevant endophenotypes, such as pathological worry fear of uncertainty, and neuroticism. We inspect clinical genetic evidence for the familialityl heritability of GAD and cross-disorder phenot...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2017-06-01 00:00:00
abstract：:Wider use of pharmacological models would facilitate the development of new drugs for Alzheimer's disease (AD), The two main models currently used are based on the cholinergic and glutamatergic hypotheses of AD, Although they lead to some of the attention and memory impairment observed in AD, they do not fully reprodu...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：:Increased physician prescribing of opioids to treat chronic nonprogressive pain has been accompanied by an increase in opioid addiction. Twin studies of opioid addiction are consistent with an inherited component of risk, approximately 50%. Several genome-wide association study (GWAS) reports indicate that genetic ris...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2017-09-01 00:00:00
abstract：:Major depressive disorder (MDD) is a major public health concern. Despite tremendous advances, the pathogenic mechanisms associated with MDD are still unclear. Moreover, a significant number of MDD subjects do not respond to the currently available medication. MicroRNAs (miRNAs) are a class of small noncoding RNAs tha...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2014-03-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2002-12-01 00:00:00
abstract：:Epidemiological studies show that anxiety disorders are highly prevalent and an important cause of functional impairment; they constitute the most frequent menial disorders in the community. Phobias are the most common with the highest rates for simple phobia and agoraphobia. Panic disorder (PD) and obsessive-compulsi...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：:Inborn errors of metabolism (IEMs) are particularly frequent as diseases of the nervous system. In the pediatric neurologic presentations of IEMs neurodevelopment is constantly disturbed and in fact, as far as biochemistry is involved, any kind of monogenic disease can become an IEM. Clinical features are very diverse...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2018-12-01 00:00:00
abstract：:The relationship between stress and infertility has been debated for years. Women with infertility report elevated levels of anxiety and depression, so it is clear that infertility causes stress. What is less clear, however, is whether or not stress causes infertility. The impact of distress on treatment outcome is di...
journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2018-03-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
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doi：
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
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更新日期：1999-12-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 历史文章,杂志文章,评审
doi：
更新日期：2018-09-01 00:00:00
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
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doi：
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章,评审
doi：
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
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journal_title：Dialogues in clinical neuroscience
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
