Preserving cognition, quality of life, physical health and functional ability in Alzheimer's disease: the effect of physical exercise (ADEX trial): rationale and design.

abstract：:Parkinson's and Alzheimer's diseases are age-related degenerative disorders that share common clinical, pathological and biochemical features. Epidemiological studies demonstrate a similar distribution of the disease in place and time. Causes of death and populations at higher risk are similar. These findings suggest ...

journal_title：Neuroepidemiology

authors： Treves TA,Chandra V,Korczyn AD

更新日期：1993-01-01 00:00:00

abstract：:The advent of new laboratory methods and noninvasive imaging modalities has extended the diagnostic possibilities in normal individuals. This article elaborates the new options for the assessment of stroke risk offered by these techniques. In this context we present the Austrian Stroke Prevention Study, which is the f...

journal_title：Neuroepidemiology

authors： Schmidt R,Lechner H,Fazekas F,Niederkorn K,Reinhart B,Grieshofer P,Horner S,Offenbacher H,Koch M,Eber B

更新日期：1994-01-01 00:00:00

abstract：:There is increasing evidence that oxidative stress is involved in cerebral aging and dementia. The objective of this review is to give a progress report on the more recent results of the various epidemiologic cohorts studied for the association between nutrition of older people, the evolution of cognitive performances...

journal_title：Neuroepidemiology

authors： Deschamps V,Barberger-Gateau P,Peuchant E,Orgogozo JM

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND/AIMS:Neurosarcoidosis is a rare condition with serious health consequences. However, little is known about clinical characteristics and outcome of neurosarcoidosis in the community setting. METHODS:Patients with neurosarcoidosis were identified from a previously described cohort of patients with incident sa...

journal_title：Neuroepidemiology

authors： Ungprasert P,Crowson CS,Matteson EL

更新日期：2017-01-01 00:00:00

abstract：:Using a case-control method, we studied the role of environmental risk factors and viral infection in the development of Parkinson's disease (PD) in China. Ninety-three PD patients and 186 controls were investigated with a questionnaire and from most of them, blood was taken to test the antibody levels of four virus (...

journal_title：Neuroepidemiology

authors： Wang WZ,Fang XH,Cheng XM,Jiang DH,Lin ZJ

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Hereditary cerebellar ataxias (HCA) and hereditary spastic paraplegias (HSP) are two groups of neurodegenerative disorders that usually present with progressive gait impairment, often leading to permanent disability. Advances in genetic research in the last decades have improved their diagnosis and brought n...

journal_title：Neuroepidemiology

authors： Ruano L,Melo C,Silva MC,Coutinho P

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:It is believed that an interaction between genetic and non-genetic factors may be involved in the development of amyotrophic lateral sclerosis (ALS). With the exception of exposure to agricultural chemicals like pesticides, evidence of an association between environmental risk factors and ALS is inconsistent...

journal_title：Neuroepidemiology

authors： Povedano M,Saez M,Martínez-Matos JA,Barceló MA

更新日期：2018-01-01 00:00:00

abstract：:Most available data on the prognosis of epileptic seizures come from hospital-based clinics in which patients with chronic or severe disease are over-represented. The National General Practice Study of Epilepsy and Epileptic Seizures is a large prospective community-based study of people with newly diagnosed seizures ...

journal_title：Neuroepidemiology

authors： Hart YM,Sander JW,Sharvon SD

更新日期：1989-01-01 00:00:00

abstract：:Homocysteine is a metabolite of methionine that may be remethylated by enzymes requiring folate and cobalamin (vitamin B12) to again form methionine or catabolized by the pyridoxine (vitamin B6) dependent enzyme, cystathionine beta synthase (CBS) to form cysteine (fig. 1) [1]. Homocysteine exists as a combination of v...

journal_title：Neuroepidemiology

authors： Sacco RL,Roberts JK,Jacobs BS

更新日期：1998-01-01 00:00:00

abstract：:We consider the problem of testing that a disease with variable age at onset is an autosomal dominant or recessive genetic trait. Specific reference is made to Alzheimer's disease and recent publications proposing an autosomal dominant inheritance pattern. The pedigree structure allowed is restricted to first-degree r...

journal_title：Neuroepidemiology

authors： Sobel E,Davanipour Z,Alter M

更新日期：1988-01-01 00:00:00

abstract：:Since the middle of this century, a remarkable concentration of cases of neurodegenerative disease(s), referred to as amyotrophic lateral sclerosis and Parkinson-dementia complex (ALS/PDC), has been recognized among Chamorro natives of Guam. Intense investigations over the last 4 decades have failed to determine the e...

journal_title：Neuroepidemiology

authors： Wiederholt WC

更新日期：1999-01-01 00:00:00

abstract：:This paper describes a proposed study to investigate the incidence of dementia in a population of over 75 year olds in Melton Mowbray, Leicestershire, England. The study population (n = 438) underwent a detailed psychiatric assessment using the Cambridge Examination for Mental Disorders of the Elderly (CAMDEX) as the ...

journal_title：Neuroepidemiology

authors： Jagger C,Clarke M,Anderson J

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND/AIMS:Brain tumors are the second most common pediatric malignancy. The literature suggests that one of the most common subtypes of malignant childhood brain tumor, medulloblastoma, has some seasonal variation in incidence by month of birth. METHODS:Data from cases in the Central Brain Tumor Registry of the ...

journal_title：Neuroepidemiology

authors： Hoffman S,Schellinger KA,Propp JM,McCarthy BJ,Campbell RT,Davis FG

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:We validated a new method of identifying patients with incident myasthenia in automated Danish registers for the purpose of conducting epidemiological studies of the disorder. METHODS:For residents of a Danish county (population 484,862) in 1993-2008, we identified any hospital contacts coded for myasthenia...

journal_title：Neuroepidemiology

authors： Pedersen EG,Hallas J,Hansen K,Jensen PE,Gaist D

更新日期：2011-01-01 00:00:00

abstract：:This study is a time series analysis of the utilization of L-dopa derivatives (LDD) and bromocriptine by parkinsonism (PA) patients and of the age-specific PA prevalences estimated by using a previously reported model. The model combines information on LDD sales, infant mortality rates (IMR) and demographic data for S...

journal_title：Neuroepidemiology

authors： de Pedro J,Rosenqvist U

更新日期：1985-01-01 00:00:00

abstract：:Between 1992 and 2040, the United States nonwhite elderly population is expected to grow from 3.3 to 14.1 million. In order to assess the implications of this increase on the mortality from neurodegenerative diseases in the United States, we used Census Bureau population estimates to formulate projections of the annua...

journal_title：Neuroepidemiology

authors： Lilienfeld DE,Perl DP

更新日期：1994-01-01 00:00:00

abstract：:According to studies done before 1980, the multiple sclerosis (MS) prevalence rate in Italy ranged from 7.2 to 27.1 cases per 100,000 inhabitants. More recent work has consistently put the MS prevalence rate to over 30 cases per 100,000 inhabitants. If these recent data are confirmed in the future, Italy can no longer...

journal_title：Neuroepidemiology

authors： Sironi L,Mamoli A,D'Alessandro G,Camerlingo M,Bottacchi E

更新日期：1991-01-01 00:00:00

abstract：:Trends of multiple sclerosis mortality in Spain from 1951 to 1997 are examined. Age-adjusted mortality strongly decreased from 3.08 per 100,000 women in 1951-1967 to 0.59 in 1968-1980 (similar figures were obtained for men). This decrease seems to be due to an artifact produced by changes in codification of causes of ...

journal_title：Neuroepidemiology

authors： Llorca J,Guerrero-Alonso P,Prieto-Salceda D

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Anthropometric indexes are powerful indicators of the environment and the plasticity of the human body. This study aimed at exploring the anthropometric indexes that are associated with late-life cognition impairment among the elderly Chinese in the Shanghai Aging Study. METHODS:The height, weight, and sitt...

journal_title：Neuroepidemiology

authors： Liang X,Li X,Ding D,Zhao Q,Luo J,Guo Q,Hong Z

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The results of analytical studies show that the association between hypertension and the risk of Parkinson's disease (PD) remains controversial. METHOD:We searched studies related to the association between hypertension and the risk of PD. We pooled the ORs and risk ratios (RRs) with 95% confidence interval...

journal_title：Neuroepidemiology

authors： Chen J,Zhang C,Wu Y,Zhang D

更新日期：2019-01-01 00:00:00

abstract：:Infectious viruses and bacteria can trigger multiple sclerosis (MS) exacerbations. Seasonally changing concentrations of ambient air pollutants are known to predispose to transmissible infections, to induce systemic immune responses and to enhance existing peripheral inflammation. Ambient air quality and monthly MS re...

journal_title：Neuroepidemiology

authors： Oikonen M,Laaksonen M,Laippala P,Oksaranta O,Lilius EM,Lindgren S,Rantio-Lehtimäki A,Anttinen A,Koski K,Erälinna JP

更新日期：2003-01-01 00:00:00

abstract：:Although cognitive screening test scores change with advanced age, the significance of these changes (particularly decline in score) needs to be defined in terms of general health and neuropsychological functioning. Such analysis was undertaken in a subgroup of 287 healthy older men (mean age at baseline = 70.7 years)...

journal_title：Neuroepidemiology

authors： Eslinger PJ,Swan GE,Carmelli D

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Familial aggregation has been shown for Alzheimer's disease (AD) and Parkinson's disease (PD) separately, and it has been hypothesized that these diseases also coaggregate in families. METHODS:The authors investigated familial coaggregation of AD and PD by conducting a systematic review and meta-analysis. P...

journal_title：Neuroepidemiology

authors： Feldman AL,Johansson AL,Lambert PC,Sieurin J,Yang F,Pedersen NL,Wirdefeldt K

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The goal of this study was to assess the validity of a screening question for head tremor in essential tremor (ET). There are no published data on this topic, and the knowledge will guide future epidemiological investigations of this disorder. METHODS:These analyses utilized four distinct patient samples: a...

journal_title：Neuroepidemiology

authors： Louis ED,Michalec M

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Mild cognitive impairment (MCI) has been suggested as a term for a boundary area between normal aging and dementia. This study was designed to determine the prevalence of MCI in the elderly in the Hebei province, China, and explore its related factors. METHODS:Participants included 2,601 community-dwelling ...

journal_title：Neuroepidemiology

authors： Xu S,Xie B,Song M,Yu L,Wang L,An C,Zhu Q,Han K,Zhao X,Zhang R,Dong L,Chai N,Gao Y,Zhang Q,Wang X

更新日期：2014-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic and progressively disabling inflammatory autoimmune disorder of the central nervous system. MS has a multifactorial etiology and is triggered by environmental factors in individuals with complex genetic risk profiles. The epidemiology of MS changes with the spatial and temporal dis...

journal_title：Neuroepidemiology

authors： Al-Afasy HH,Al-Obaidan MA,Al-Ansari YA,Al-Yatama SA,Al-Rukaibi MS,Makki NI,Suresh A,Akhtar S

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Despite decades of research, there are no national estimates of the incidence or prevalence of spinal cord injury (SCI) in Canada. Our objective was to utilize the best available data to estimate the incidence and prevalence of traumatic SCI (TSCI) and non-traumatic SCI (NTSCI) in Canada for 2010. METHODS:I...

journal_title：Neuroepidemiology

authors： Noonan VK,Fingas M,Farry A,Baxter D,Singh A,Fehlings MG,Dvorak MF

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:In Central/Eastern European countries, cerebrovascular diseases are among the leading causes of mortality. We aimed to determine the incidence of first-ever stroke (FES) in the north-western part of Croatia. METHODS:A population-based prospective incidence study was conducted between July 1, 2007, and June ...

journal_title：Neuroepidemiology

authors： Pikija S,Cvetko D,Malojčić B,Trkanjec Z,Pavliček I,Lukić A,Kopjar A,Hajduk M,Andrović A,Bilić-Genter M,Trkulja V

更新日期：2012-01-01 00:00:00

abstract：:An increased risk for first-degree relatives (FDR) of glioma patients has previously been observed. The novel objective of this study was to investigate differences in familial risk among FDR of low-grade glioma (LGG) and high-grade glioma (HGG) cases, respectively. Two cohorts were constructed, one from 15,321 FDR of...

journal_title：Neuroepidemiology

authors： Malmer B,Henriksson R,Grönberg H

更新日期：2002-11-01 00:00:00

abstract：:Risk factors for amyotrophic lateral sclerosis (ALS) such as country of residence, hard labour, intense athletic activities, heavy metal and pet exposure, skeletal trauma, surgical procedures, malignancies, and recurrent infectious disease were investigated in 77 patients and 80 controls, matching the cases for select...

journal_title：Neuroepidemiology

authors： Provinciali L,Giovagnoli AR

更新日期：1990-01-01 00:00:00