Abstract:
BACKGROUND/AIMS:Brain tumors are the second most common pediatric malignancy. The literature suggests that one of the most common subtypes of malignant childhood brain tumor, medulloblastoma, has some seasonal variation in incidence by month of birth. METHODS:Data from cases in the Central Brain Tumor Registry of the United States, including primary brain tumor cases diagnosed in children (0-19 years) between the years 1995 and 2001 from 13 state cancer registries, were analyzed to determine whether there was seasonal variation. Analyses were performed using Edwards' test for sinusoidal variation, which uses case frequencies per month, and tests whether frequencies follow a sine function over 12 months. RESULTS:Seasonal variation in incidence by month of birth was highly statistically significant for medulloblastoma, not otherwise specified (NOS) (p = 0.016), with the peak occurring in October. Medulloblastoma, NOS also demonstrated seasonal variation in incidence by month of birth in children aged 5-19 (p = 0.041), especially females aged 5-19 (p = 0.034), with the peak in October. There were no significant results for brain tumors overall, or for the other most common pediatric tumor subtypes (pilocytic astrocytoma, other astrocytoma, and ependymoma). CONCLUSION:These preliminary results indicate seasonal variation unique to medulloblastoma incidence by month of birth and may provide evidence for an environmental exposure etiology, though further studies are needed to explore specific hypotheses.
journal_name
Neuroepidemiologyjournal_title
Neuroepidemiologyauthors
Hoffman S,Schellinger KA,Propp JM,McCarthy BJ,Campbell RT,Davis FGdoi
10.1159/000109502subject
Has Abstractpub_date
2007-01-01 00:00:00pages
89-95issue
1-2eissn
0251-5350issn
1423-0208pii
000109502journal_volume
29pub_type
杂志文章abstract::The relationship between smoking status and incident Alzheimer's disease (AD) was investigated in a random stratified sample of a biracial community in Chicago. Analyses are based on 1,064 persons (of 1,134 evaluated) who had data on smoking status, disease incidence, and key covariates such as apolipoprotein allele s...
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journal_title:Neuroepidemiology
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pub_type: 杂志文章,多中心研究
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110759
更新日期:1990-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110929
更新日期:1992-01-01 00:00:00
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journal_title:Neuroepidemiology
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doi:10.1159/000110396
更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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更新日期:2019-01-01 00:00:00
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journal_title:Neuroepidemiology
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110924
更新日期:1992-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-01-01 00:00:00
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更新日期:2008-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:The clinical characteristics of multiple sclerosis (MS) are not well defined in Hispanic populations. We hypothesized that disease presentation in Hispanic white (HW) patients will be different from non-Hispanic white (NHW) patients given their ancestral background and reported lower disease prevalence. This ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000068748
更新日期:2003-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00