Abstract:
:Since the middle of this century, a remarkable concentration of cases of neurodegenerative disease(s), referred to as amyotrophic lateral sclerosis and Parkinson-dementia complex (ALS/PDC), has been recognized among Chamorro natives of Guam. Intense investigations over the last 4 decades have failed to determine the etiology of these invariably fatal diseases. Over the same time period, the incidence of ALS has decreased dramatically, the incidence of PDC has decreased, but to a lesser degree, and age at onset has shifted to a later age by about 1 decade. Almost 50% of demented patients present without the classical Parkinsonian features of PDC, and the morphological picture has changed. Results of past and present research initiatives are reviewed.
journal_name
Neuroepidemiologyjournal_title
Neuroepidemiologyauthors
Wiederholt WCdoi
10.1159/000026223subject
Has Abstractpub_date
1999-01-01 00:00:00pages
279-91issue
6eissn
0251-5350issn
1423-0208pii
26223journal_volume
18pub_type
历史文章,杂志文章,评审abstract::This study is based on 166 patients with definite multiple sclerosis (MS) residing in different Italian regions and on 332 parents and 326 siblings. Seven patients had a first-degree relative with a definite diagnosis. The comparison with a population age-matched for specific frequency of MS showed an increase of the ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110198
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:We aimed to determine whether vascular risk factors are associated with Alzheimer's disease (AD) and mild cognitive impairment (MCI) in an elderly Arab population. METHODS:An Arabic-speaking team performed a door-to-door survey of consecutive residents aged > or =65 years. We estimated the odds of AD or MCI...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000264828
更新日期:2010-01-01 00:00:00
abstract::Little is known regarding the pathogenetic factors for Alzheimer's disease (AD). We studied 63 AD patients in order to evaluate if there were clinical subtypes of AD and whether prior illnesses and life-styles were involved in the development of the disease. In our patients selected for onset of symptoms before age 65...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110750
更新日期:1990-01-01 00:00:00
abstract::This paper presents the current status and use of virtual reality (VR) for children with attention deficit hyperactivity disorder (ADHD), autism and cerebral palsy. This literature review explores how VR systems have been used as treatment tools to address the primary impairments of these disorders. Three major classe...
journal_title:Neuroepidemiology
pub_type: 杂志文章,评审
doi:10.1159/000320847
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Genetic association studies conducted in admixed populations may be confounded by population stratification resulting in spurious associations. The purpose of this pilot study was to determine the presence and effect of population stratification in a case-control study of brain arteriovenous malformation (BA...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000160215
更新日期:2008-01-01 00:00:00
abstract::Mortality rates from motor neuron disease (MND) in Spain were analysed for the years 1960-1989, a period in which 3,530 deaths were recorded from the disease and during which the crude annual mortality rate ranged between 0.35 and 0.95 deaths per 100,000 persons. Whilst the crude mortality rate fell by 54% during the ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000109906
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Hereditary ataxias (HA) comprise a group of genetically heterogeneous rare diseases. As important public health problems to be monitored, this study analyses the morbimortality of HA in Spain. METHODS:Data were extracted from the national death index (1981-2008), using the International Classification of Di...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000346275
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND/AIMS:Neurosarcoidosis is a rare condition with serious health consequences. However, little is known about clinical characteristics and outcome of neurosarcoidosis in the community setting. METHODS:Patients with neurosarcoidosis were identified from a previously described cohort of patients with incident sa...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000477300
更新日期:2017-01-01 00:00:00
abstract::In the past several years, a substantial amount of new information on the epidemiology and pathophysiology of diabetes and vascular disease has become available. Autopsy studies suggest that diabetic patients are susceptible to cerebral small-artery disease and lacunar infarction and may be at risk for large-artery at...
journal_title:Neuroepidemiology
pub_type: 杂志文章,评审
doi:10.1159/000026190
更新日期:1999-01-01 00:00:00
abstract::The Canadian Study of Health and Aging (CSHA) provided a population-based estimate of the prevalence of dementia of 8% for those aged 65 and older. Other studies have produced both higher and lower prevalence estimates. Factors that may contribute to these differences include: the use of or the reliance on neuropsycho...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000026247
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:While some personality traits may reduce risk of dementia, this is controversial and has not been studied as much among diverse populations. We examined associations between 2 traits - Conscientiousness and Openness to Experience - and risk of dementia among black and white older adults. METHODS:We studied ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000492821
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To determine the age and sex variations in the relationship between diabetes and stroke. METHODS:This analysis was based on data from 61,327 Canadians > or =45 years of age who participated in the Canadian Community Health Survey in 2000-2001. Logistic regression analysis was conducted to evaluate the associ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000097856
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneous disorder, with a variable reported prevalence ranging from 0.5 to 12 per 100,000. The aim of this retrospective study was to evaluate the prevalence of HSP and estimate the percentage of SPG4 mutations in the Estonian populatio...
journal_title:Neuroepidemiology
pub_type: 杂志文章,多中心研究
doi:10.1159/000177033
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Several studies conducted in hospital emergency departments have shown that most patients delay in responding to stroke symptoms. In the general population, recognition of stroke and the appropriate reactions are important for prevention and acute treatment, particularly in areas with a high stroke incidence...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000328867
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:The clinical characteristics of multiple sclerosis (MS) are not well defined in Hispanic populations. We hypothesized that disease presentation in Hispanic white (HW) patients will be different from non-Hispanic white (NHW) patients given their ancestral background and reported lower disease prevalence. This ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000431375
更新日期:2015-01-01 00:00:00
abstract::Mortality rates for deaths 'due to' and 'with' hereditary ataxias are presented for the first time. Age-adjusted mortality rates were higher for whites than for nonwhites of either sex, and for men in both racial groups. Age-specific mortality rates for whites showed a peak for 'hereditary spinal ataxia' in the 20-29 ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110182
更新日期:1989-01-01 00:00:00
abstract::Some dementias, such as Creutzfeldt-Jakob disease, may result from transmissible agents. To assess the possibility of a blood-borne transmissible agent in Alzheimer's disease (AD), we compared informant-reported history of blood transfusions among 326 newly recognized probable AD cases and 330 control subjects of simi...
journal_title:Neuroepidemiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000109675
更新日期:1997-01-01 00:00:00
abstract::White matter lesions (WMLs) detected by cerebral magnetic resonance imaging (MRI) are putatively a consequence of cerebral hypoperfusion or ischemia. We investigated the prevalence, severity and correlates of WMLs in a population-based sample of 1,920 African-American and European-American men and women aged 55-72 yea...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000368814
更新日期:1997-01-01 00:00:00
abstract::The incidence rate for primary intracranial neoplasms in the province of Trento (Italy) is 8.5/100,000/year, but the figures in the eleven administrative units ('comprensori') are different. The increased rates in C6 Val di Non and C10 Vallagarina are mainly due to the number of malignant tumors in the 45- to 64-year-...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110825
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:We examined the prevalence of cardiac and cerebrovascular disease among hospitalized patients with and without multiple sclerosis (MS). METHODS:This study used the Statewide Planning and Research Cooperate System data set of over 15 million hospitalizations in New York City from 1988 through 2002. We identi...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000128103
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:In Central/Eastern European countries, cerebrovascular diseases are among the leading causes of mortality. We aimed to determine the incidence of first-ever stroke (FES) in the north-western part of Croatia. METHODS:A population-based prospective incidence study was conducted between July 1, 2007, and June ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000336114
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Lifespan is 6-10 years shorter in multiple sclerosis (MS), but the reasons remain unclear. Using linked clinical- and population-based administrative health databases, we compared cause-specific mortality in an MS cohort to the general population. METHODS:MS patients in British Columbia (BC), Canada, were f...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000504804
更新日期:2020-01-01 00:00:00
abstract::Although cognitive screening test scores change with advanced age, the significance of these changes (particularly decline in score) needs to be defined in terms of general health and neuropsychological functioning. Such analysis was undertaken in a subgroup of 287 healthy older men (mean age at baseline = 70.7 years)...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000067113
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Patients with multiple sclerosis (MS) may have a higher risk of cardiovascular diseases (CVD) than the general population, but data are limited. METHODS:We conducted a population-based cohort study involving Danish citizens diagnosed with MS (n = 13,963) from 1977 to 2006 and an age- and sex-matched populat...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000320245
更新日期:2010-01-01 00:00:00
abstract::According to studies done before 1980, the multiple sclerosis (MS) prevalence rate in Italy ranged from 7.2 to 27.1 cases per 100,000 inhabitants. More recent work has consistently put the MS prevalence rate to over 30 cases per 100,000 inhabitants. If these recent data are confirmed in the future, Italy can no longer...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110249
更新日期:1991-01-01 00:00:00
abstract::All death certificates with amyotrophic lateral sclerosis (ALS) or motor neuron disease (MND) as the primary or underlying cause occurring among Kentucky residents between 1964 and 1984 were manually reviewed. Geographic variability within Kentucky was evident for three intervals, 1964-1967, 1968-1978, and 1979-1984, ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110168
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND/AIMS:Brain tumors are the second most common pediatric malignancy. The literature suggests that one of the most common subtypes of malignant childhood brain tumor, medulloblastoma, has some seasonal variation in incidence by month of birth. METHODS:Data from cases in the Central Brain Tumor Registry of the ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000109502
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Recent interest in antihypertensive agents, especially calcium channel blockers, has been sparked by the notion that these medications may be neuroprotective. A modest literature, with mixed results, has examined whether these medications might lower the odds or risk of Parkinson's disease (PD) or dementia. ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000235641
更新日期:2009-01-01 00:00:00
abstract::The knowledge of the prevalence of spinal cord disorders (SCD) is important to understand specific causes in each part of the worldand to allow to potentially adapt health care and public policy including law enforcement to the main causes. SCD have important personal, biopsychological, socio-economic, short-term and ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000348320
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Using data from a recent report that indicated a 2-fold higher risk of amyotrophic lateral sclerosis (ALS) among veterans of the 1991 Gulf War, we applied capture-recapture methodology to estimate possible under-ascertainment of ALS cases among deployed and non-deployed military personnel who were on active d...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000083297
更新日期:2005-01-01 00:00:00