Neuroepidemiologic research initiatives on Guam: past and present.

Abstract:

:Since the middle of this century, a remarkable concentration of cases of neurodegenerative disease(s), referred to as amyotrophic lateral sclerosis and Parkinson-dementia complex (ALS/PDC), has been recognized among Chamorro natives of Guam. Intense investigations over the last 4 decades have failed to determine the etiology of these invariably fatal diseases. Over the same time period, the incidence of ALS has decreased dramatically, the incidence of PDC has decreased, but to a lesser degree, and age at onset has shifted to a later age by about 1 decade. Almost 50% of demented patients present without the classical Parkinsonian features of PDC, and the morphological picture has changed. Results of past and present research initiatives are reviewed.

journal_name

Neuroepidemiology

journal_title

Neuroepidemiology

authors

Wiederholt WC

doi

10.1159/000026223

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

279-91

issue

6

eissn

0251-5350

issn

1423-0208

pii

26223

journal_volume

18

pub_type

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