Diabetes mellitus and cerebrovascular disease.

Abstract:

:In the past several years, a substantial amount of new information on the epidemiology and pathophysiology of diabetes and vascular disease has become available. Autopsy studies suggest that diabetic patients are susceptible to cerebral small-artery disease and lacunar infarction and may be at risk for large-artery atherosclerotic occlusive disease. Epidemiological studies show that diabetes is a risk factor for ischemic stroke. The pathogenesis of diabetes-associated stroke appears to be linked to excessive glycation and oxidation, endothelial dysfunction, increased platelet aggregation, impaired fibrinolysis and insulin resistance. Macrovascular complications may be prevented by simple primary prevention measures including exercise, weight loss and treatment of dyslipidemia. The role of tight glycemic control in reducing the risk of stroke is still uncertain. Many new insights and treatment strategies are expected in the future.

journal_name

Neuroepidemiology

journal_title

Neuroepidemiology

authors

Lukovits TG,Mazzone TM,Gorelick TM

doi

10.1159/000026190

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

1-14

issue

1

eissn

0251-5350

issn

1423-0208

pii

ned18001

journal_volume

18

pub_type

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