Abstract:
:The aim of the study was to evaluate how the natural history of multiple sclerosis (MS) had changed over a 15-year period. We compared disability and mortality in a cohort of 83 MS patients hospitalised in the Neurological Institute of Pavia, northern Italy, from January 1, 1990, to December 31, 1991, with a similar cohort of 52 patients analysed in the past. After the follow-up, an unfavourable course (death or relevant disability) was observed in 41% of the patients in the new cohort, compared to 63.5% of the patients in the old one. The percentage of deceased patients was reduced from 25 to 6%. The analysis of the pooled data of the two cohorts indicates a recent tendency of firstly hospitalised patients having a shorter disease duration and a lower disability level, which could explain the relevant decrease both in mortality and disability. Finally, our findings confirmed that age at onset, early disability and a short interval between onset and secondary progression increase the risk of an unfavourable course.
journal_name
Neuroepidemiologyjournal_title
Neuroepidemiologyauthors
Bergamaschi R,Montomoli C,Candeloro E,Fratti C,Citterio A,Cosi Vdoi
10.1159/000085308subject
Has Abstractpub_date
2005-01-01 00:00:00pages
15-8issue
1eissn
0251-5350issn
1423-0208pii
85308journal_volume
25pub_type
杂志文章abstract::In 1994 several European studies will have available risk factor information on incident cases of dementia collected in prospective community-based studies. These centers will collaborate in a nested-case control study based on the pooled cases and a sample of the non-diseased respondents. This paper describes the gen...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000111005
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:The risk of dementia increases by 15-28% in patients with type 2 diabetes mellitus (DM). However, studies on dementia risk in type 1 DM have been neither comprehensive nor conclusive. METHODS:We carried out a cohort study involving 1,077 patients registered to have type 1 DM from 1998 to 2009 and 32,310 mat...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000486719
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Patients with multiple sclerosis (MS) may have a higher risk of cardiovascular diseases (CVD) than the general population, but data are limited. METHODS:We conducted a population-based cohort study involving Danish citizens diagnosed with MS (n = 13,963) from 1977 to 2006 and an age- and sex-matched populat...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000320245
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Lifespan is 6-10 years shorter in multiple sclerosis (MS), but the reasons remain unclear. Using linked clinical- and population-based administrative health databases, we compared cause-specific mortality in an MS cohort to the general population. METHODS:MS patients in British Columbia (BC), Canada, were f...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000504804
更新日期:2020-01-01 00:00:00
abstract::Human neurocysticercosis (NC) is a parasitic disease caused by TAENIA SOLIUM when its larvae lodge in the central nervous system. NC prevalence estimates are obscured by the variable and often asymptomatic clinical picture. While infection depends on exposure, severity is possibly related with various host factors (im...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000068748
更新日期:2003-03-01 00:00:00
abstract:BACKGROUND/AIM:Parkinson's disease (PD) is often complicated by psychiatric comorbidity, which is likely to lead to a higher use of mental health care facilities. In addition, psychiatric symptomatology and associated mental health care use may be present even before motor symptoms and PD are diagnosed, as the pathophy...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000116243
更新日期:2008-01-01 00:00:00
abstract::According to studies done before 1980, the multiple sclerosis (MS) prevalence rate in Italy ranged from 7.2 to 27.1 cases per 100,000 inhabitants. More recent work has consistently put the MS prevalence rate to over 30 cases per 100,000 inhabitants. If these recent data are confirmed in the future, Italy can no longer...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110249
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Limited epidemiological data exist about amyotrophic lateral sclerosis (ALS) in the United States (US). The Agency for Toxic Substances and Disease Registry maintains the National ALS Registry and funded state and metropolitan surveillance projects to obtain reliable, timely information about ALS in defined ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000365850
更新日期:2014-01-01 00:00:00
abstract::This study is a time series analysis of the utilization of L-dopa derivatives (LDD) and bromocriptine by parkinsonism (PA) patients and of the age-specific PA prevalences estimated by using a previously reported model. The model combines information on LDD sales, infant mortality rates (IMR) and demographic data for S...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110228
更新日期:1985-01-01 00:00:00
abstract::Cerebrovascular diseases (CVDs) constitute the most frequent cause of death in Spain. In order to identify the geographical pattern of CVD mortality, age- and sex-specific as well as age-adjusted mortality rates (ICD-8,9 rubrics 430-438) were calculated for the period 1975-1986 for each province in the country. Maps w...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000109792
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:The clinical characteristics of multiple sclerosis (MS) are not well defined in Hispanic populations. We hypothesized that disease presentation in Hispanic white (HW) patients will be different from non-Hispanic white (NHW) patients given their ancestral background and reported lower disease prevalence. This ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000431375
更新日期:2015-01-01 00:00:00
abstract::The Canadian Study of Health and Aging (CSHA) provided a population-based estimate of the prevalence of dementia of 8% for those aged 65 and older. Other studies have produced both higher and lower prevalence estimates. Factors that may contribute to these differences include: the use of or the reliance on neuropsycho...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000026247
更新日期:2000-05-01 00:00:00
abstract::Infectious viruses and bacteria can trigger multiple sclerosis (MS) exacerbations. Seasonally changing concentrations of ambient air pollutants are known to predispose to transmissible infections, to induce systemic immune responses and to enhance existing peripheral inflammation. Ambient air quality and monthly MS re...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000067108
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND AND METHODS:The high prevalence of epilepsy detected in rural Tanzania by Dr. Jilek-Aall since 1960, was verified by the World Health Organization (WHO) survey on neurological and seizure disorders. Neurologists and psychiatrists further interviewed both patients and controls using standard methods. The pres...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000054797
更新日期:2001-10-01 00:00:00
abstract::From July 1988 to June 1989, the etiology was registered of 520 patients with generalized neuropathy in 5 neurological centers in Taiwan. The neuropathy was diabetic in 256 cases (49.23%), alcoholic in 45 (8.65%), inflammatory in 34 (6.53%; including 21 with acute inflammatory demyelinating polyneuropathy, 12 with chr...
journal_title:Neuroepidemiology
pub_type: 杂志文章,多中心研究
doi:10.1159/000110326
更新日期:1993-01-01 00:00:00
abstract::A comparison of epidemiological and clinical features of trigeminal neuralgia (TN) and glossopharyngeal neuralgia (GN) in Rochester, Minn., reveals several differences. The overall age- and sex-adjusted annual incidence rates were significantly higher for TN than for GN (4.7 vs. 0.8 per 100,000 population). The TN:GN ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110284
更新日期:1991-01-01 00:00:00
abstract::White matter lesions (WML) on MRI of the brain are common in both demented and nondemented older persons. They may be due to ischemic events and are associated with cognitive and physical impairments. It is not known whether the prevalence of these WML in the general population differs across European countries in a p...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000089233
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND/AIMS:The prevalence of epilepsy in Algeria is unknown. The aims of this multicenter transversal study were to determine the national prevalence and clinical characteristics of epilepsy in the Algerian population. METHODS:This two-phase study was conducted in 5 circumscriptions and included 8,046 subjects ag...
journal_title:Neuroepidemiology
pub_type: 杂志文章,多中心研究
doi:10.1159/000339637
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is increasing evidence that the pathophysiologic mechanisms are different between migraine and tension-type headache. The aim of the study was to determine possible sociodemographic differences in Saudi Arabia subjects with headache. METHODOLOGY:A community-based door-to-door survey with i...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000109670
更新日期:1997-01-01 00:00:00
abstract::Mortality rates for deaths 'due to' and 'with' hereditary ataxias are presented for the first time. Age-adjusted mortality rates were higher for whites than for nonwhites of either sex, and for men in both racial groups. Age-specific mortality rates for whites showed a peak for 'hereditary spinal ataxia' in the 20-29 ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110182
更新日期:1989-01-01 00:00:00
abstract::The multiple sclerosis (MS) mortality 1968-1977 in France, as reported by Alpérovitch and Bouvier, was tested for a possible correlation with a number of sociogeographic variables from relevant periods. The MS rate was associated with the main industry groups (metal processing and textile industry), with industry as a...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110759
更新日期:1990-01-01 00:00:00
abstract::Although cognitive screening test scores change with advanced age, the significance of these changes (particularly decline in score) needs to be defined in terms of general health and neuropsychological functioning. Such analysis was undertaken in a subgroup of 287 healthy older men (mean age at baseline = 70.7 years)...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000067113
更新日期:2003-01-01 00:00:00
abstract::Recent reports of declining trends in mortality rates from cerebrovascular disease are based on underlying cause of death as stated on the death certificate, and may contain inaccuracies because death certificates are often completed without reference to all information in medical records, and because of changes in co...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110160
更新日期:1989-01-01 00:00:00
abstract::The advent of new laboratory methods and noninvasive imaging modalities has extended the diagnostic possibilities in normal individuals. This article elaborates the new options for the assessment of stroke risk offered by these techniques. In this context we present the Austrian Stroke Prevention Study, which is the f...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110396
更新日期:1994-01-01 00:00:00
abstract::The knowledge of the prevalence of spinal cord disorders (SCD) is important to understand specific causes in each part of the worldand to allow to potentially adapt health care and public policy including law enforcement to the main causes. SCD have important personal, biopsychological, socio-economic, short-term and ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000348320
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Prevalence and incidence rates of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are required to determine the impact of CIDP on society. We aimed to estimate the prevalence and incidence of CIDP worldwide and to determine the effect of diagnostic criteria on prevalence and incidence. METH...
journal_title:Neuroepidemiology
pub_type: 杂志文章,meta分析
doi:10.1159/000494291
更新日期:2019-01-01 00:00:00
abstract::A random sample of nursing home residents over 65 years of age were interviewed. Two hundred ninety-two participants received the Short Portable Mental Status Questionnaire. Two hundred eleven were unable to answer the questionnaire, but their caregivers provided information about their daily activities and performanc...
journal_title:Neuroepidemiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000026166
更新日期:1998-01-01 00:00:00
abstract::Previously, we studied the effect of population ancestry on the risk of multiple sclerosis (MS) in US veterans of World War II, comparing by state 1980 US census ancestry data with MS case/control ratios. Here, the joint effects of population ancestry and surname-derived ethnicity on MS risk are examined in the same s...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000109804
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:We aimed to determine the accuracy of the iScore for predicting mortality and early disability following ischemic stroke in a French population-based study. METHODS:All patients with acute ischemic stroke were identified among residents of the city of Dijon, France, between 2006 and 2011, using a population...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000354634
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:We explored the association between ionizing radiation (IR) from pre-natal and post-natal radio-diagnostic procedures and brain cancer risk within the MOBI-kids study. METHODS:MOBI-kids is an international (Australia, Austria, Canada, France, Germany, Greece, India, Israel, Italy, Japan, Korea, New Zealand,...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000506131
更新日期:2020-01-01 00:00:00