Abstract:
:There is increasing evidence that oxidative stress is involved in cerebral aging and dementia. The objective of this review is to give a progress report on the more recent results of the various epidemiologic cohorts studied for the association between nutrition of older people, the evolution of cognitive performances and the risk of later occurrence of dementia or stroke. The oxidative theory of pathological brain ageing is supported by animal laboratory experiments. Furthermore, experimental research has consistently suggested that diet-related factors play an important role in cognitive functions in ageing. In humans, a number of epidemiological case-control and prospective studies analyzed the association between nutrition, particularly fatty acids and antioxidant molecules (vitamins A, E, C, beta-carotene and polyphenols) and cognition. In the context of evidence already available, further studies are needed to identify the specific role of various nutrients, their interactions and the influence of genetic factors and living habits on cerebral aging and dementia. Vascular dementia and Alzheimer's disease, that share several risk factors, might be targets for primary prevention through nutritional recommendations and/or supplementation.
journal_name
Neuroepidemiologyjournal_title
Neuroepidemiologyauthors
Deschamps V,Barberger-Gateau P,Peuchant E,Orgogozo JMdoi
10.1159/000054752subject
Has Abstractpub_date
2001-02-01 00:00:00pages
7-15issue
1eissn
0251-5350issn
1423-0208pii
54752journal_volume
20pub_type
杂志文章,评审abstract:OBJECTIVE:The clinical characteristics of multiple sclerosis (MS) are not well defined in Hispanic populations. We hypothesized that disease presentation in Hispanic white (HW) patients will be different from non-Hispanic white (NHW) patients given their ancestral background and reported lower disease prevalence. This ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000431375
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To determine the age and sex variations in the relationship between diabetes and stroke. METHODS:This analysis was based on data from 61,327 Canadians > or =45 years of age who participated in the Canadian Community Health Survey in 2000-2001. Logistic regression analysis was conducted to evaluate the associ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000097856
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Short-term exposure to high levels of air pollution can increase stroke risk. In this study we investigated the short-term effects of air pollution on hospital admissions for stroke in a setting where pollutant levels are rather low. We also addressed methodological issues in evaluating the short-term effect...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000274807
更新日期:2010-01-01 00:00:00
abstract::This paper describes a proposed study to investigate the incidence of dementia in a population of over 75 year olds in Melton Mowbray, Leicestershire, England. The study population (n = 438) underwent a detailed psychiatric assessment using the Cambridge Examination for Mental Disorders of the Elderly (CAMDEX) as the ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110980
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND/AIM:Parkinson's disease (PD) is often complicated by psychiatric comorbidity, which is likely to lead to a higher use of mental health care facilities. In addition, psychiatric symptomatology and associated mental health care use may be present even before motor symptoms and PD are diagnosed, as the pathophy...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000116243
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/AIMS:Neurosarcoidosis is a rare condition with serious health consequences. However, little is known about clinical characteristics and outcome of neurosarcoidosis in the community setting. METHODS:Patients with neurosarcoidosis were identified from a previously described cohort of patients with incident sa...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000477300
更新日期:2017-01-01 00:00:00
abstract::Since the middle of this century, a remarkable concentration of cases of neurodegenerative disease(s), referred to as amyotrophic lateral sclerosis and Parkinson-dementia complex (ALS/PDC), has been recognized among Chamorro natives of Guam. Intense investigations over the last 4 decades have failed to determine the e...
journal_title:Neuroepidemiology
pub_type: 历史文章,杂志文章,评审
doi:10.1159/000026223
更新日期:1999-01-01 00:00:00
abstract::Little is known regarding the pathogenetic factors for Alzheimer's disease (AD). We studied 63 AD patients in order to evaluate if there were clinical subtypes of AD and whether prior illnesses and life-styles were involved in the development of the disease. In our patients selected for onset of symptoms before age 65...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110750
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:We assessed the incidence and determinants of aphasia attributable to first-ever acute stroke. We also investigated early and long-term mortality and 1-year dependence in post-stroke patients. METHODS:A 10-year prospective hospital-based study was conducted in the prefecture of Athens, Greece. RESULTS:In t...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000222091
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To assess the knowledge of stroke in the general public in the Gulf Cooperation Council (GCC) countries. BACKGROUND:The Arabian Gulf is a rapidly developing part of the world with major changes in the lifestyle that can increase the risk of stroke. To design effective stroke treatment and prevention strategi...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000112856
更新日期:2007-01-01 00:00:00
abstract::The epsilon 4 allele of the apolipoprotein E (apoE) is associated with Alzheimer's disease (AD) and also with elevated serum total cholesterol and low-density lipoprotein levels. However, the interrelationships between apoE genotype, plasma cholesterol levels and AD risk have been studied very little. We examined the ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000026149
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Higher education is associated with a lower risk of dementia, possibly because of a higher tolerance to subclinical neurodegenerative pathology. Whether higher education also protects against dementia after clinical stroke or transient ischemic attack (TIA) remains unknown. METHODS:Within the population-bas...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000443649
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The results of analytical studies show that the association between hypertension and the risk of Parkinson's disease (PD) remains controversial. METHOD:We searched studies related to the association between hypertension and the risk of PD. We pooled the ORs and risk ratios (RRs) with 95% confidence interval...
journal_title:Neuroepidemiology
pub_type: 杂志文章,meta分析
doi:10.1159/000496977
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Transversal studies have underlined the association between the decline in autonomic nervous system (ANS) activity and all-cause mortality. However, the predictive value of ANS has never been prospectively assessed in a general population-based cohort. METHOD:The PROOF (PROgnostic indicator OF cardiovascula...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000108914
更新日期:2007-01-01 00:00:00
abstract::In 1994 several European studies will have available risk factor information on incident cases of dementia collected in prospective community-based studies. These centers will collaborate in a nested-case control study based on the pooled cases and a sample of the non-diseased respondents. This paper describes the gen...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000111005
更新日期:1992-01-01 00:00:00
abstract:INTRODUCTION:Amyotrophic lateral sclerosis (ALS) is a rare, rapidly progressive neurodegenerative disease. Despite wide variability in the incidence and prevalence of ALS, there is evidence of positive temporal trends and an increase in incidence with age. The aim of this study was to conduct a detailed epidemiological...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000477126
更新日期:2017-01-01 00:00:00
abstract::Cerebrovascular diseases (CVDs) constitute the most frequent cause of death in Spain. In order to identify the geographical pattern of CVD mortality, age- and sex-specific as well as age-adjusted mortality rates (ICD-8,9 rubrics 430-438) were calculated for the period 1975-1986 for each province in the country. Maps w...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000109792
更新日期:1995-01-01 00:00:00
abstract::Iatrogenic Creutzfeldt-Jakob disease (CJD) has never been reported among recipients of dura mater grafts processed in the US. We recently investigated a report of such a case in a 72-year-old man with a typical clinical presentation of CJD. We found no evidence of CJD in either the 34-year-old donor or in other, proxi...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000026240
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:Repetitive head trauma is an identified risk factor for Alzheimer's disease (AD). The violence in wife assault is repetitive and targets the head. This association provides a rationale for studying the relationship between spousal abuse and AD. DESIGN:To preliminarily evaluate the possibility of an increase...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000093894
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Recent interest in antihypertensive agents, especially calcium channel blockers, has been sparked by the notion that these medications may be neuroprotective. A modest literature, with mixed results, has examined whether these medications might lower the odds or risk of Parkinson's disease (PD) or dementia. ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000235641
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Genetic association studies conducted in admixed populations may be confounded by population stratification resulting in spurious associations. The purpose of this pilot study was to determine the presence and effect of population stratification in a case-control study of brain arteriovenous malformation (BA...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000160215
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Systematic reviews and meta-analyses on the incidence and prevalence of neurological conditions are important methods of quantifying the burden and risk of disease. METHODS:The rigorous methodology required in order to minimize publication bias, account for study heterogeneity, and variation in study qualit...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000355533
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Incidence and prevalence studies of neurological disorders play an extremely important role in hypothesis-generation, assessing the burden of disease and planning of health services. However, the assessment of disease estimates is hindered by the poor quality of reporting for such studies. We developed the S...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000439132
更新日期:2015-01-01 00:00:00
abstract:AIMS:To evaluate the effect of medical record use on figures for the incidence of dementia and the effect of apolipoprotein E (APOE) polymorphism on this incidence and neuropathologically defined Alzheimer's disease (AD) in very elderly individuals. METHODS:Cognitive functions were examined in a cohort of 328 (92% of ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000090252
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There is increasing evidence that the pathophysiologic mechanisms are different between migraine and tension-type headache. The aim of the study was to determine possible sociodemographic differences in Saudi Arabia subjects with headache. METHODOLOGY:A community-based door-to-door survey with i...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000109670
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Prevalence and incidence rates of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are required to determine the impact of CIDP on society. We aimed to estimate the prevalence and incidence of CIDP worldwide and to determine the effect of diagnostic criteria on prevalence and incidence. METH...
journal_title:Neuroepidemiology
pub_type: 杂志文章,meta分析
doi:10.1159/000494291
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Mild cognitive impairment (MCI) has been suggested as a term for a boundary area between normal aging and dementia. This study was designed to determine the prevalence of MCI in the elderly in the Hebei province, China, and explore its related factors. METHODS:Participants included 2,601 community-dwelling ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000357374
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND/AIMS:Results of recently conducted prospective studies have demonstrated that the presence of high titers of anti-EBNA-1 or anti-EBNA complex IgG antibodies in healthy individuals is a strong risk factor for multiple sclerosis (MS). Antibodies to BZLF1, the product of the homonymous early lytic gene, have be...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000108113
更新日期:2007-01-01 00:00:00
abstract::The relationship between smoking status and incident Alzheimer's disease (AD) was investigated in a random stratified sample of a biracial community in Chicago. Analyses are based on 1,064 persons (of 1,134 evaluated) who had data on smoking status, disease incidence, and key covariates such as apolipoprotein allele s...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000091654
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Studies on dyskinesia and Parkinson's syndrome associated with chronic kidney disease or end-stage renal disease (ESRD) have been mainly limited to case reports or case series studies. This population-based study investigated the risk of Parkinson's disease in patients with ESRD. METHODS:From a universal in...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000358921
更新日期:2014-01-01 00:00:00