Abstract:
:The epsilon 4 allele of the apolipoprotein E (apoE) is associated with Alzheimer's disease (AD) and also with elevated serum total cholesterol and low-density lipoprotein levels. However, the interrelationships between apoE genotype, plasma cholesterol levels and AD risk have been studied very little. We examined the possible role of serum total cholesterol in the pathogenesis of AD in a population-based sample of 444 men, aged 70-89 years, who were survivors of the Finnish cohorts of the Seven Countries Study. Previous high serum cholesterol level (mean level > or = 6.5 mmol/l) was a significant predictor of the prevalence of AD (odds ratio = 3.1; 95% confidence interval = 1.2, 8.5) after controlling for age and the presence of apoE epsilon 4 allele. In men who subsequently developed AD the cholesterol level decreased before the clinical manifestations of AD. We conclude that high serum total cholesterol may be an independent risk factor for AD and some of the effect of the apoE epsilon 4 allele on risk of AD might be mediated through high serum cholesterol.
journal_name
Neuroepidemiologyjournal_title
Neuroepidemiologyauthors
Notkola IL,Sulkava R,Pekkanen J,Erkinjuntti T,Ehnholm C,Kivinen P,Tuomilehto J,Nissinen Adoi
10.1159/000026149subject
Has Abstractpub_date
1998-01-01 00:00:00pages
14-20issue
1eissn
0251-5350issn
1423-0208pii
ned17014journal_volume
17pub_type
杂志文章abstract::The advent of new laboratory methods and noninvasive imaging modalities has extended the diagnostic possibilities in normal individuals. This article elaborates the new options for the assessment of stroke risk offered by these techniques. In this context we present the Austrian Stroke Prevention Study, which is the f...
journal_title:Neuroepidemiology
pub_type: 杂志文章
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doi:10.1159/000110750
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journal_title:Neuroepidemiology
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journal_title:Neuroepidemiology
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journal_title:Neuroepidemiology
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doi:10.1159/000110168
更新日期:1989-01-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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journal_title:Neuroepidemiology
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doi:10.1159/000505815
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更新日期:2002-03-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110186
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journal_title:Neuroepidemiology
pub_type: 杂志文章,评审
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更新日期:1998-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110284
更新日期:1991-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000026211
更新日期:1999-01-01 00:00:00
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更新日期:2013-01-01 00:00:00
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journal_title:Neuroepidemiology
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doi:10.1159/000054797
更新日期:2001-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:Neuroepidemiology
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更新日期:2003-05-01 00:00:00
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更新日期:2001-02-01 00:00:00
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更新日期:2010-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110106
更新日期:1987-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章,评审
doi:10.1159/000026169
更新日期:1998-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000368814
更新日期:1997-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000128103
更新日期:2008-01-01 00:00:00
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更新日期:2007-01-01 00:00:00