Abstract:
:We explored the relationship between amyotrophic lateral sclerosis (ALS) and cigarette smoking in a case-control study conducted in New England from 1993 to 1996. Recently diagnosed ALS cases (n = 109) were recruited from two major referral centers. Population controls (n = 256) were identified by random telephone screening. Data were analyzed by logistic regression. After adjusting for age, sex, region and education, ever having smoked cigarettes was associated with an increase in risk for ALS (odds ratio 1.7; 95% confidence interval 1.0-2.8). Average cigarettes smoked per day, years smoked and pack-years were all greater in cases than controls, but dose-response trends were not observed. Similar numbers of cases and controls had ever used alcohol, and only a small, nonsignificant association of drinks per month with ALS was observed. The association of cigarette smoking with ALS was not affected by adjusting for alcohol use. In contrast, the weak relationship of ALS with alcohol use was apparently due to confounding by smoking.
journal_name
Neuroepidemiologyjournal_title
Neuroepidemiologyauthors
Kamel F,Umbach DM,Munsat TL,Shefner JM,Sandler DPdoi
10.1159/000026211subject
Has Abstractpub_date
1999-01-01 00:00:00pages
194-202issue
4eissn
0251-5350issn
1423-0208pii
26211journal_volume
18pub_type
杂志文章abstract:BACKGROUND:Short-term exposure to high levels of air pollution can increase stroke risk. In this study we investigated the short-term effects of air pollution on hospital admissions for stroke in a setting where pollutant levels are rather low. We also addressed methodological issues in evaluating the short-term effect...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000274807
更新日期:2010-01-01 00:00:00
abstract::The multiple sclerosis (MS) mortality 1968-1977 in France, as reported by Alpérovitch and Bouvier, was tested for a possible correlation with a number of sociogeographic variables from relevant periods. The MS rate was associated with the main industry groups (metal processing and textile industry), with industry as a...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110759
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND/AIMS:The prevalence of epilepsy in Algeria is unknown. The aims of this multicenter transversal study were to determine the national prevalence and clinical characteristics of epilepsy in the Algerian population. METHODS:This two-phase study was conducted in 5 circumscriptions and included 8,046 subjects ag...
journal_title:Neuroepidemiology
pub_type: 杂志文章,多中心研究
doi:10.1159/000339637
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:To assess the prevalence of essential tremor (ET) in two Spanish populations (Irun and Hondarribia, Bidasoa region) and to compare the results with those of similar surveys. METHODS:The survey included 2,000 participants aged 65 years or older in a door-to-door, two-phase design. ET was defined as postural ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000054771
更新日期:2001-05-01 00:00:00
abstract::Infectious viruses and bacteria can trigger multiple sclerosis (MS) exacerbations. Seasonally changing concentrations of ambient air pollutants are known to predispose to transmissible infections, to induce systemic immune responses and to enhance existing peripheral inflammation. Ambient air quality and monthly MS re...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000067108
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Smoking increases the risk of multiple sclerosis (MS) and possibly disease progression. The reliability of self-reported smoking status is unknown in MS. We assessed the reliability of self-reported smoking status among participants in the North American Research Committee on Multiple Sclerosis (NARCOMS) Reg...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000170910
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The purpose of the study is to investigate the epidemiology of Creutzfeldt-Jakob disease (CJD) and multiple sclerosis (MS) in Taiwan. METHODS:Cases of CJD and MS were identified from the National Health Insurance Research Database from January 2000 to December 2005. Age- and sex-specific incidences of these...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000229779
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The goal of this study was to assess the validity of a screening question for head tremor in essential tremor (ET). There are no published data on this topic, and the knowledge will guide future epidemiological investigations of this disorder. METHODS:These analyses utilized four distinct patient samples: a...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000365991
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:No epidemiological studies on the prevalence of compressive neuropathy have been undertaken in Arab countries. The aim of the study was to estimate the prevalence of the most common types of compressive neuropathies in Qena governorate/Egypt. METHODS:The study was part of a community-based survey carried ou...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000444641
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:It is believed that an interaction between genetic and non-genetic factors may be involved in the development of amyotrophic lateral sclerosis (ALS). With the exception of exposure to agricultural chemicals like pesticides, evidence of an association between environmental risk factors and ALS is inconsistent...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000489664
更新日期:2018-01-01 00:00:00
abstract::The advent of new laboratory methods and noninvasive imaging modalities has extended the diagnostic possibilities in normal individuals. This article elaborates the new options for the assessment of stroke risk offered by these techniques. In this context we present the Austrian Stroke Prevention Study, which is the f...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110396
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Lifespan is 6-10 years shorter in multiple sclerosis (MS), but the reasons remain unclear. Using linked clinical- and population-based administrative health databases, we compared cause-specific mortality in an MS cohort to the general population. METHODS:MS patients in British Columbia (BC), Canada, were f...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000504804
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The clinical characteristics of multiple sclerosis (MS) are not well defined in Hispanic populations. We hypothesized that disease presentation in Hispanic white (HW) patients will be different from non-Hispanic white (NHW) patients given their ancestral background and reported lower disease prevalence. This ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000431375
更新日期:2015-01-01 00:00:00
abstract::Since the middle of this century, a remarkable concentration of cases of neurodegenerative disease(s), referred to as amyotrophic lateral sclerosis and Parkinson-dementia complex (ALS/PDC), has been recognized among Chamorro natives of Guam. Intense investigations over the last 4 decades have failed to determine the e...
journal_title:Neuroepidemiology
pub_type: 历史文章,杂志文章,评审
doi:10.1159/000026223
更新日期:1999-01-01 00:00:00
abstract::The knowledge of the prevalence of spinal cord disorders (SCD) is important to understand specific causes in each part of the worldand to allow to potentially adapt health care and public policy including law enforcement to the main causes. SCD have important personal, biopsychological, socio-economic, short-term and ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000348320
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Incidence and prevalence studies of neurological disorders play an extremely important role in hypothesis-generation, assessing the burden of disease and planning of health services. However, the assessment of disease estimates is hindered by the poor quality of reporting for such studies. We developed the S...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000439132
更新日期:2015-01-01 00:00:00
abstract::Iatrogenic Creutzfeldt-Jakob disease (CJD) has never been reported among recipients of dura mater grafts processed in the US. We recently investigated a report of such a case in a 72-year-old man with a typical clinical presentation of CJD. We found no evidence of CJD in either the 34-year-old donor or in other, proxi...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000026240
更新日期:2000-03-01 00:00:00
abstract::We tested the feasibility of a fully automated brain MRI voxel count technique--automated labeling pathway (ALP)--in a sample of 15 demented and 13 cognitively normal women (age 75-85 years) participating to the Cardiovascular Health Study (CHS). We hypothesized that ALP would replicate well-established findings of th...
journal_title:Neuroepidemiology
pub_type: 临床试验,杂志文章
doi:10.1159/000085140
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:While some personality traits may reduce risk of dementia, this is controversial and has not been studied as much among diverse populations. We examined associations between 2 traits - Conscientiousness and Openness to Experience - and risk of dementia among black and white older adults. METHODS:We studied ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000492821
更新日期:2019-01-01 00:00:00
abstract::Using a case-control method, we studied the role of environmental risk factors and viral infection in the development of Parkinson's disease (PD) in China. Ninety-three PD patients and 186 controls were investigated with a questionnaire and from most of them, blood was taken to test the antibody levels of four virus (...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110319
更新日期:1993-01-01 00:00:00
abstract::We carried out a door-to-door survey in rural areas of the Cordillera Province, Bolivia, to determine the prevalence of the most common neurological diseases in a sample of about 10,000 inhabitants. A team of non-doctor health workers administered a standard screening instrument for neurological diseases, a slightly m...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000048624
更新日期:2002-03-01 00:00:00
abstract::White matter lesions (WML) on MRI of the brain are common in both demented and nondemented older persons. They may be due to ischemic events and are associated with cognitive and physical impairments. It is not known whether the prevalence of these WML in the general population differs across European countries in a p...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000089233
更新日期:2006-01-01 00:00:00
abstract::The black Caribbean population continues to grow in the US and little is known about stroke etiologies in that community. We examined stroke subtypes in 175 consecutive Haitian-born patients living in Miami, admitted for acute stroke. Ischemic stroke was diagnosed in 72%. Small vessel occlusion was the most frequent s...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000087449
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND/AIMS:Neurosarcoidosis is a rare condition with serious health consequences. However, little is known about clinical characteristics and outcome of neurosarcoidosis in the community setting. METHODS:Patients with neurosarcoidosis were identified from a previously described cohort of patients with incident sa...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000477300
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:We explored the association between ionizing radiation (IR) from pre-natal and post-natal radio-diagnostic procedures and brain cancer risk within the MOBI-kids study. METHODS:MOBI-kids is an international (Australia, Austria, Canada, France, Germany, Greece, India, Israel, Italy, Japan, Korea, New Zealand,...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000506131
更新日期:2020-01-01 00:00:00
abstract::In neuroepidemiologic research, there are many pitfalls to trap unwary investigators, whether the project is a survey, a case-control study, or some other type of study. We briefly discuss pitfalls relating to: research preliminaries (e.g., failure to decide on study objectives); personnel and training (e.g., deficien...
journal_title:Neuroepidemiology
pub_type: 杂志文章,评审
doi:10.1159/000026153
更新日期:1998-01-01 00:00:00
abstract::Parkinson's and Alzheimer's diseases are age-related degenerative disorders that share common clinical, pathological and biochemical features. Epidemiological studies demonstrate a similar distribution of the disease in place and time. Causes of death and populations at higher risk are similar. These findings suggest ...
journal_title:Neuroepidemiology
pub_type: 杂志文章,评审
doi:10.1159/000110337
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Exercise is hypothesized to improve cognition, physical performance, functional ability and quality of life, but evidence is scarce. Previous studies were of short duration, often underpowered and involving home-based light exercise programs in patients with undefined dementia. The aim of the ADEX ('Preservi...
journal_title:Neuroepidemiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000354632
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND AND METHODS:The high prevalence of epilepsy detected in rural Tanzania by Dr. Jilek-Aall since 1960, was verified by the World Health Organization (WHO) survey on neurological and seizure disorders. Neurologists and psychiatrists further interviewed both patients and controls using standard methods. The pres...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000054797
更新日期:2001-10-01 00:00:00
abstract::Mortality rates from motor neuron disease (MND) in Spain were analysed for the years 1960-1989, a period in which 3,530 deaths were recorded from the disease and during which the crude annual mortality rate ranged between 0.35 and 0.95 deaths per 100,000 persons. Whilst the crude mortality rate fell by 54% during the ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000109906
更新日期:1996-01-01 00:00:00