Ambient air quality and occurrence of multiple sclerosis relapse.

Abstract:

:Infectious viruses and bacteria can trigger multiple sclerosis (MS) exacerbations. Seasonally changing concentrations of ambient air pollutants are known to predispose to transmissible infections, to induce systemic immune responses and to enhance existing peripheral inflammation. Ambient air quality and monthly MS relapse occurrence in south-western Finland were compared by multivariate logistic regression. The odds ratio of the risk of a relapse onset was over fourfold (4.143, p < 0.001) when the concentration of inhalable particulate matter (PM(10)) was at the highest quartile. Inhalable airborne particulate matter concentrations were connected to relapse occurrence. Poor air quality may enhance the seasonal changes in MS relapse occurrence by an increased susceptibility to transmissible infections.

journal_name

Neuroepidemiology

journal_title

Neuroepidemiology

authors

Oikonen M,Laaksonen M,Laippala P,Oksaranta O,Lilius EM,Lindgren S,Rantio-Lehtimäki A,Anttinen A,Koski K,Erälinna JP

doi

10.1159/000067108

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

95-9

issue

1

eissn

0251-5350

issn

1423-0208

pii

67108

journal_volume

22

pub_type

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