Does Alzheimer's disease protect against cancers? A nationwide population-based study.

Abstract:

BACKGROUND:Previous studies suggested a decreased risk of cancer among patients with Alzheimer's disease (AD). There is still a lack of data on the specific types of cancer, the risk factors, and the impact of cholinesterase inhibitors on developing cancer in AD. METHODS:We performed a nationwide population-based study of 6,960 patients with AD between 1997 and 2006 using Taiwan's National Health Insurance database. Patterns of cancer incidence in AD patients were compared with those of the general population using standardized incidence ratios (SIRs). RESULTS:Patients with AD had a reduced risk of developing overall cancer [SIR = 0.88, 95% confidence interval (CI) = 0.80-0.97]. Specifically, patients with AD were protected from lung cancers (SIR = 0.75, 95% CI = 0.57-0.98), especially men (SIR = 0.61, 95% CI = 0.40-0.88). In subgroup analyses, women, patients aged 60-79 years, and those diagnosed as having AD for more than 1 year were more likely to be protected from cancers. CONCLUSIONS:Our study demonstrates a decreased incidence of overall cancers in patients with AD, a finding lower than but consistent with Western countries. Patients with AD had a significantly decreased risk of lung cancer. Further investigation of genetic evidence linking AD to cancer is warranted.

journal_name

Neuroepidemiology

journal_title

Neuroepidemiology

authors

Ou SM,Lee YJ,Hu YW,Liu CJ,Chen TJ,Fuh JL,Wang SJ

doi

10.1159/000341411

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

42-9

issue

1

eissn

0251-5350

issn

1423-0208

pii

000341411

journal_volume

40

pub_type

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