Abstract:
BACKGROUND:Previous studies suggested a decreased risk of cancer among patients with Alzheimer's disease (AD). There is still a lack of data on the specific types of cancer, the risk factors, and the impact of cholinesterase inhibitors on developing cancer in AD. METHODS:We performed a nationwide population-based study of 6,960 patients with AD between 1997 and 2006 using Taiwan's National Health Insurance database. Patterns of cancer incidence in AD patients were compared with those of the general population using standardized incidence ratios (SIRs). RESULTS:Patients with AD had a reduced risk of developing overall cancer [SIR = 0.88, 95% confidence interval (CI) = 0.80-0.97]. Specifically, patients with AD were protected from lung cancers (SIR = 0.75, 95% CI = 0.57-0.98), especially men (SIR = 0.61, 95% CI = 0.40-0.88). In subgroup analyses, women, patients aged 60-79 years, and those diagnosed as having AD for more than 1 year were more likely to be protected from cancers. CONCLUSIONS:Our study demonstrates a decreased incidence of overall cancers in patients with AD, a finding lower than but consistent with Western countries. Patients with AD had a significantly decreased risk of lung cancer. Further investigation of genetic evidence linking AD to cancer is warranted.
journal_name
Neuroepidemiologyjournal_title
Neuroepidemiologyauthors
Ou SM,Lee YJ,Hu YW,Liu CJ,Chen TJ,Fuh JL,Wang SJdoi
10.1159/000341411subject
Has Abstractpub_date
2013-01-01 00:00:00pages
42-9issue
1eissn
0251-5350issn
1423-0208pii
000341411journal_volume
40pub_type
杂志文章abstract::Seizures precipitated by the stimulus of hot water known as 'hot water epilepsy' (HWE) have been commonly reported from South India. The present report outlines certain descriptive epidemiological aspects of 78 cases from two rural satellite clinics of National Institute of Mental Health and Neuro Sciences (NIMHANS), ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110929
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pub_type: 杂志文章
doi:10.1159/000110377
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000026247
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Neuroepidemiology
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000083000
更新日期:2005-01-01 00:00:00
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journal_title:Neuroepidemiology
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journal_title:Neuroepidemiology
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更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000093894
更新日期:2006-01-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章,多中心研究
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更新日期:2005-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110924
更新日期:1992-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章,多中心研究
doi:10.1159/000110326
更新日期:1993-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章,评审
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更新日期:1998-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
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更新日期:2002-09-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2014-01-01 00:00:00