Abstract:
:Some dementias, such as Creutzfeldt-Jakob disease, may result from transmissible agents. To assess the possibility of a blood-borne transmissible agent in Alzheimer's disease (AD), we compared informant-reported history of blood transfusions among 326 newly recognized probable AD cases and 330 control subjects of similar age and sex, randomly selected from the same health maintenance organization population. Since risk of AD is increased in persons with apolipoprotein E epsilon 4 (APOE-e4) alleles, we examined whether the transfusion-AD relationship varies by APOE genotype. Transfusion was more frequent among controls (17.9%) than cases (12.0%) in the overall group (crude odds ratio = 0.62; 95% confidence interval = 0.40, 0.97). Similar risks were seen for transfusions occurring < or = or > 10 years before the reference year. Stratified analysis by APOE-e4 genotype showed no effect modification. Logistic regression adjusting for age, sex, education, and presence of e4 did not change the transfusion-AD association. We conclude that a history of blood transfusion is not associated with increased risk of AD, nor does consideration of APOE-e4 status modify that conclusion.
journal_name
Neuroepidemiologyjournal_title
Neuroepidemiologyauthors
O'Meara ES,Kukull WA,Schellenberg GD,Bowen JD,McCormick WC,Teri L,Pfanschmidt M,Thompson JD,Larson EBdoi
10.1159/000109675subject
Has Abstractpub_date
1997-01-01 00:00:00pages
86-93issue
2eissn
0251-5350issn
1423-0208journal_volume
16pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:The 'Ten Questions' Questionnaire (TQQ) is used to detect severe neurological impairment in children living in resource-poor countries. Its usefulness has been established in Asia and the Caribbean, but there are a few published studies from Africa. We evaluated the TQQ as part of a larger study of neurologi...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000073977
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:While some personality traits may reduce risk of dementia, this is controversial and has not been studied as much among diverse populations. We examined associations between 2 traits - Conscientiousness and Openness to Experience - and risk of dementia among black and white older adults. METHODS:We studied ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000492821
更新日期:2019-01-01 00:00:00
abstract::Most available data on the prognosis of epileptic seizures come from hospital-based clinics in which patients with chronic or severe disease are over-represented. The National General Practice Study of Epilepsy and Epileptic Seizures is a large prospective community-based study of people with newly diagnosed seizures ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110186
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Limited epidemiological data exist about amyotrophic lateral sclerosis (ALS) in the United States (US). The Agency for Toxic Substances and Disease Registry maintains the National ALS Registry and funded state and metropolitan surveillance projects to obtain reliable, timely information about ALS in defined ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000365850
更新日期:2014-01-01 00:00:00
abstract::The Global Burden of Disease (GBD) study is a long-standing effort to report consistent and comprehensive measures of disease burden for the world. In this paper, we describe the methods used to estimate the global burden of stroke for the GBD 2013 study. Pathologic subtypes of stroke are modeled separately for two mu...
journal_title:Neuroepidemiology
pub_type: 杂志文章,评审
doi:10.1159/000441083
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Charcot-Marie-Tooth disease (CMT) is a group of clinically and genetically heterogeneous disorders that primarily affect the peripheral nervous system. Epidemiological studies of CMT have not yet been performed in Korea. OBJECTIVES:This study was performed to estimate the prevalence of CMT in Korea and the ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000505815
更新日期:2020-01-01 00:00:00
abstract::Since the middle of this century, a remarkable concentration of cases of neurodegenerative disease(s), referred to as amyotrophic lateral sclerosis and Parkinson-dementia complex (ALS/PDC), has been recognized among Chamorro natives of Guam. Intense investigations over the last 4 decades have failed to determine the e...
journal_title:Neuroepidemiology
pub_type: 历史文章,杂志文章,评审
doi:10.1159/000026223
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Lifespan is 6-10 years shorter in multiple sclerosis (MS), but the reasons remain unclear. Using linked clinical- and population-based administrative health databases, we compared cause-specific mortality in an MS cohort to the general population. METHODS:MS patients in British Columbia (BC), Canada, were f...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000504804
更新日期:2020-01-01 00:00:00
abstract::We present here the results of the Sino-MONICA-Beijing stroke study based on 700,000 Beijing residents in 1984-1986. To compare incidence rates for stroke with other communities and countries, we adopted the criteria of the WHO Collaborative Study of 17 centers which used the same definition and methodology as was use...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110902
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:The results of analytical studies show that the association between hypertension and the risk of Parkinson's disease (PD) remains controversial. METHOD:We searched studies related to the association between hypertension and the risk of PD. We pooled the ORs and risk ratios (RRs) with 95% confidence interval...
journal_title:Neuroepidemiology
pub_type: 杂志文章,meta分析
doi:10.1159/000496977
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Patients with multiple sclerosis (MS) may have a higher risk of cardiovascular diseases (CVD) than the general population, but data are limited. METHODS:We conducted a population-based cohort study involving Danish citizens diagnosed with MS (n = 13,963) from 1977 to 2006 and an age- and sex-matched populat...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000320245
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Hereditary cerebellar ataxias (HCA) and hereditary spastic paraplegias (HSP) are two groups of neurodegenerative disorders that usually present with progressive gait impairment, often leading to permanent disability. Advances in genetic research in the last decades have improved their diagnosis and brought n...
journal_title:Neuroepidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000358801
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:We validated a new method of identifying patients with incident myasthenia in automated Danish registers for the purpose of conducting epidemiological studies of the disorder. METHODS:For residents of a Danish county (population 484,862) in 1993-2008, we identified any hospital contacts coded for myasthenia...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000331481
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:We explored the association between ionizing radiation (IR) from pre-natal and post-natal radio-diagnostic procedures and brain cancer risk within the MOBI-kids study. METHODS:MOBI-kids is an international (Australia, Austria, Canada, France, Germany, Greece, India, Israel, Italy, Japan, Korea, New Zealand,...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000506131
更新日期:2020-01-01 00:00:00
abstract::Infectious viruses and bacteria can trigger multiple sclerosis (MS) exacerbations. Seasonally changing concentrations of ambient air pollutants are known to predispose to transmissible infections, to induce systemic immune responses and to enhance existing peripheral inflammation. Ambient air quality and monthly MS re...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000067108
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Evidence is emerging that exposure to persistent organic pollutants (POP) is a risk factor for atherosclerosis-related diseases and for diabetes mellitus (DM). We hypothesized that residential proximity to sources of POP will be associated with an increase in hospitalization rates for ischemic stroke (IS) wi...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000316874
更新日期:2010-01-01 00:00:00
abstract::This study is a time series analysis of the utilization of L-dopa derivatives (LDD) and bromocriptine by parkinsonism (PA) patients and of the age-specific PA prevalences estimated by using a previously reported model. The model combines information on LDD sales, infant mortality rates (IMR) and demographic data for S...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110228
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Repetitive head trauma is an identified risk factor for Alzheimer's disease (AD). The violence in wife assault is repetitive and targets the head. This association provides a rationale for studying the relationship between spousal abuse and AD. DESIGN:To preliminarily evaluate the possibility of an increase...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000093894
更新日期:2006-01-01 00:00:00
abstract::We report anticipation in an extensive sample of myotonic dystrophy (MyD) kindreds taken from an epidemiological survey recently conducted in Guipúzcoa, Spain. Analysis of the parent-child pairs ascertained showed a mean anticipation of 2.86 decades (range 0-6). Greater anticipation occurred when the transmissor paren...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110362
更新日期:1994-01-01 00:00:00
abstract::This study is based on 166 patients with definite multiple sclerosis (MS) residing in different Italian regions and on 332 parents and 326 siblings. Seven patients had a first-degree relative with a definite diagnosis. The comparison with a population age-matched for specific frequency of MS showed an increase of the ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110198
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Providing a valid and sensitive measure of different domains of cognitive performance in epidemiologic studies of early old-age populations presents a methodological challenge, given the broad range of variability in cognitive functioning in this age group. OBJECTIVES:(1) To provide data on the distribution...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000328262
更新日期:2011-01-01 00:00:00
abstract::The knowledge of the prevalence of spinal cord disorders (SCD) is important to understand specific causes in each part of the worldand to allow to potentially adapt health care and public policy including law enforcement to the main causes. SCD have important personal, biopsychological, socio-economic, short-term and ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000348320
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Systematic reviews and meta-analyses on the incidence and prevalence of neurological conditions are important methods of quantifying the burden and risk of disease. METHODS:The rigorous methodology required in order to minimize publication bias, account for study heterogeneity, and variation in study qualit...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000355533
更新日期:2014-01-01 00:00:00
abstract::Several scores exist to clinically differentiate between ischemic and hemorrhagic stroke, but none has been developed in the emergency situation in which transient ischemic attack (TIA) and cerebral infarction might not yet be clearly distinguished. Information on 540 patients with ischemia (including TIA) or hemorrha...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000048608
更新日期:2002-01-01 00:00:00
abstract::Mortality rates from motor neuron disease (MND) in Spain were analysed for the years 1960-1989, a period in which 3,530 deaths were recorded from the disease and during which the crude annual mortality rate ranged between 0.35 and 0.95 deaths per 100,000 persons. Whilst the crude mortality rate fell by 54% during the ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000109906
更新日期:1996-01-01 00:00:00
abstract::Although cognitive screening test scores change with advanced age, the significance of these changes (particularly decline in score) needs to be defined in terms of general health and neuropsychological functioning. Such analysis was undertaken in a subgroup of 287 healthy older men (mean age at baseline = 70.7 years)...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000067113
更新日期:2003-01-01 00:00:00
abstract::Previously, we studied the effect of population ancestry on the risk of multiple sclerosis (MS) in US veterans of World War II, comparing by state 1980 US census ancestry data with MS case/control ratios. Here, the joint effects of population ancestry and surname-derived ethnicity on MS risk are examined in the same s...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000109804
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Prevalence and incidence rates of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are required to determine the impact of CIDP on society. We aimed to estimate the prevalence and incidence of CIDP worldwide and to determine the effect of diagnostic criteria on prevalence and incidence. METH...
journal_title:Neuroepidemiology
pub_type: 杂志文章,meta分析
doi:10.1159/000494291
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Previous studies suggested a decreased risk of cancer among patients with Alzheimer's disease (AD). There is still a lack of data on the specific types of cancer, the risk factors, and the impact of cholinesterase inhibitors on developing cancer in AD. METHODS:We performed a nationwide population-based stud...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000341411
更新日期:2013-01-01 00:00:00
abstract::There is increasing evidence that oxidative stress is involved in cerebral aging and dementia. The objective of this review is to give a progress report on the more recent results of the various epidemiologic cohorts studied for the association between nutrition of older people, the evolution of cognitive performances...
journal_title:Neuroepidemiology
pub_type: 杂志文章,评审
doi:10.1159/000054752
更新日期:2001-02-01 00:00:00