Anticipation in myotonic dystrophy: a parental-sex-related phenomenon.

Abstract:

:We report anticipation in an extensive sample of myotonic dystrophy (MyD) kindreds taken from an epidemiological survey recently conducted in Guipúzcoa, Spain. Analysis of the parent-child pairs ascertained showed a mean anticipation of 2.86 decades (range 0-6). Greater anticipation occurred when the transmissor parent was the mother. These results suggest a possible sex-related effect in the transmission of the MyD gene, and are in agreement with recent discoveries at the molecular level.

journal_name

Neuroepidemiology

journal_title

Neuroepidemiology

authors

López de Munain A,Blanco A,Emparanza JI,Martí Massó JF,Cobo A,Basauri B,Martorell L,Baiget M,Martínez Lage JM

doi

10.1159/000110362

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

75-8

issue

1-2

eissn

0251-5350

issn

1423-0208

journal_volume

13

pub_type

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