Familial coaggregation of Alzheimer's disease and Parkinson's disease: systematic review and meta-analysis.

Abstract:

BACKGROUND:Familial aggregation has been shown for Alzheimer's disease (AD) and Parkinson's disease (PD) separately, and it has been hypothesized that these diseases also coaggregate in families. METHODS:The authors investigated familial coaggregation of AD and PD by conducting a systematic review and meta-analysis. PubMed was searched for relevant studies published through the end of October 2012. Three independent investigators screened publications and extracted data. Relative risk estimates of AD risk associated with family history of PD or parkinsonism, or PD risk associated with family history of AD or dementia, were summarized into metaestimates using random effects models. Heterogeneity and publication bias were tested using Higgins' and Egger's tests, respectively. RESULTS:We included 16 studies in the review, with 14 included in any meta-analysis. AD risk associated with family history of PD yielded a summary hazard ratio of 1.18 (95% CI: 1.00-1.39) based on 5 reconstructed cohort studies and a summary odds ratio (OR) of 1.40 (95% CI: 0.92-2.12) based on 7 case-control studies. PD risk associated with family history of AD yielded a summary OR of 0.75 (95% CI: 0.49-1.16) based on 3 studies. There was no significant heterogeneity among studies, nor significant publication bias. CONCLUSIONS:There may be familial coaggregation of AD and PD, although the association was modest and only apparent when studying AD risk associated with family history of PD.

journal_name

Neuroepidemiology

journal_title

Neuroepidemiology

authors

Feldman AL,Johansson AL,Lambert PC,Sieurin J,Yang F,Pedersen NL,Wirdefeldt K

doi

10.1159/000355452

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

69-80

issue

2

eissn

0251-5350

issn

1423-0208

pii

000355452

journal_volume

42

pub_type

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