Abstract:
BACKGROUND AND AIMS:The impact of statin on dementia risk reduction has been a subject of debate over the last decade, but the evidence remains inconclusive. Therefore, we performed a meta-analysis of relevant observational studies to quantify the magnitude of the association between statin therapy and the risk of dementia. METHODS:We systematically searched for relevant studies published from January 2000 to March 2018 using EMBASE, Google, Google Scholar, PubMed, Scopus, and Web of Science. Two authors performed study selection, data abstraction, and risk of bias assessment. We then extracted data from the selected studies and performed meta-analysis of observational studies using a random-effects model. Subgroup and sensitivity analyses were also conducted. RESULTS:A total of 30 observational studies, including 9,162,509 participants (84,101 dementia patients), met the eligibility criteria. Patients with statin had a lower all-caused dementia risk than those without statin (risk ratio [RR] 0.83, 95% CI 0.79-0.87, I2 = 57.73%). The overall pooled reduction of Alzheimer disease in patients with statin use was RR 0.69 (95% CI 0.60-0.80, p < 0.0001), and the overall pooled RR of statin use and vascular dementia risk was RR 0.93 (95% CI 0.74-1.16, p = 0.54). CONCLUSION:This study suggests that the use of statin is significantly associated with a decreased risk of dementia. Future studies measuring such outcomes would provide useful information to patients, clinicians, and policymakers. Until further evidence is established, clinicians need to make sure that statin use should remain restricted to the treatment of cardiovascular disease.
journal_name
Neuroepidemiologyjournal_title
Neuroepidemiologyauthors
Poly TN,Islam MM,Walther BA,Yang HC,Wu CC,Lin MC,Li YCdoi
10.1159/000503105subject
Has Abstractpub_date
2020-01-01 00:00:00pages
214-226issue
3eissn
0251-5350issn
1423-0208pii
000503105journal_volume
54pub_type
杂志文章abstract::The advent of new laboratory methods and noninvasive imaging modalities has extended the diagnostic possibilities in normal individuals. This article elaborates the new options for the assessment of stroke risk offered by these techniques. In this context we present the Austrian Stroke Prevention Study, which is the f...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110396
更新日期:1994-01-01 00:00:00
abstract::This study is a time series analysis of the utilization of L-dopa derivatives (LDD) and bromocriptine by parkinsonism (PA) patients and of the age-specific PA prevalences estimated by using a previously reported model. The model combines information on LDD sales, infant mortality rates (IMR) and demographic data for S...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110228
更新日期:1985-01-01 00:00:00
abstract::The purpose of our study was to determine the incidence of stroke, case-fatality rate and disability at 1 year in the Valley of Aosta (Italy) in the years 2004 and 2005. All suspected strokes occurring between January 1, 2004, and December 31, 2005, in the resident population of the Valley of Aosta were identified acc...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000195688
更新日期:2009-01-01 00:00:00
abstract::Stroke and ischemic heart disease (IHD) mortality rates were analyzed in Brazilian subjects older than 30 years of age from 1979 to 1996. Population estimates were based on census surveys. Mortality data were obtained from the Ministry of Health. For stroke, the age-adjusted death rate (ADR) dropped from 200 to 164 an...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000069893
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND/AIMS:Neurosarcoidosis is a rare condition with serious health consequences. However, little is known about clinical characteristics and outcome of neurosarcoidosis in the community setting. METHODS:Patients with neurosarcoidosis were identified from a previously described cohort of patients with incident sa...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000477300
更新日期:2017-01-01 00:00:00
abstract::The multiple sclerosis (MS) prevalence rates in five districts of Bulgaria were compared with some geographic and climatic factors. In Bulgaria the latitude seems not to be a factor influencing the MS distribution. As to the climatic factors, a negative correlation was obtained between MS prevalence and mean annual su...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110106
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND AND METHODS:The high prevalence of epilepsy detected in rural Tanzania by Dr. Jilek-Aall since 1960, was verified by the World Health Organization (WHO) survey on neurological and seizure disorders. Neurologists and psychiatrists further interviewed both patients and controls using standard methods. The pres...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000054797
更新日期:2001-10-01 00:00:00
abstract::Previously, we studied the effect of population ancestry on the risk of multiple sclerosis (MS) in US veterans of World War II, comparing by state 1980 US census ancestry data with MS case/control ratios. Here, the joint effects of population ancestry and surname-derived ethnicity on MS risk are examined in the same s...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000109804
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Guillain-Barré syndrome (GBS) is a potentially life-threatening disease that typically occurs after a preceding infectious disease. An accurate estimation of GBS incidence would be useful for investigating the potential causal relationships between risk factors and GBS. Here we described the nationwide incid...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000430917
更新日期:2015-01-01 00:00:00
abstract::Most available data on the prognosis of epileptic seizures come from hospital-based clinics in which patients with chronic or severe disease are over-represented. The National General Practice Study of Epilepsy and Epileptic Seizures is a large prospective community-based study of people with newly diagnosed seizures ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110186
更新日期:1989-01-01 00:00:00
abstract::All death certificates with amyotrophic lateral sclerosis (ALS) or motor neuron disease (MND) as the primary or underlying cause occurring among Kentucky residents between 1964 and 1984 were manually reviewed. Geographic variability within Kentucky was evident for three intervals, 1964-1967, 1968-1978, and 1979-1984, ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110168
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Genetic association studies conducted in admixed populations may be confounded by population stratification resulting in spurious associations. The purpose of this pilot study was to determine the presence and effect of population stratification in a case-control study of brain arteriovenous malformation (BA...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000160215
更新日期:2008-01-01 00:00:00
abstract::The Global Burden of Disease (GBD) study is a long-standing effort to report consistent and comprehensive measures of disease burden for the world. In this paper, we describe the methods used to estimate the global burden of stroke for the GBD 2013 study. Pathologic subtypes of stroke are modeled separately for two mu...
journal_title:Neuroepidemiology
pub_type: 杂志文章,评审
doi:10.1159/000441083
更新日期:2015-01-01 00:00:00
abstract::A pilot case-control study was conducted to identify possible risk factors for Meige's syndrome. Patients with Meige's syndrome and age- and sex-matched controls suffering from other neurological diseases were recruited from the Movement Disorders Clinic and Neurology Outpatient Department of the All India Insititute ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000026265
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:Previous studies suggested a decreased risk of cancer among patients with Alzheimer's disease (AD). There is still a lack of data on the specific types of cancer, the risk factors, and the impact of cholinesterase inhibitors on developing cancer in AD. METHODS:We performed a nationwide population-based stud...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000341411
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:While some personality traits may reduce risk of dementia, this is controversial and has not been studied as much among diverse populations. We examined associations between 2 traits - Conscientiousness and Openness to Experience - and risk of dementia among black and white older adults. METHODS:We studied ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000492821
更新日期:2019-01-01 00:00:00
abstract::Using a case-control method, we studied the role of environmental risk factors and viral infection in the development of Parkinson's disease (PD) in China. Ninety-three PD patients and 186 controls were investigated with a questionnaire and from most of them, blood was taken to test the antibody levels of four virus (...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110319
更新日期:1993-01-01 00:00:00
abstract::Many Parkinson's disease (PD) patients treated with levodopa develop motor fluctuations and/or dyskinesia. This large, retrospective study was conducted to compare the prevalence and treatment of dyskinesia in PD patients in seven countries. A total of 380 physicians were interviewed and completed patient record forms...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000111578
更新日期:2007-01-01 00:00:00
abstract::The epidemiology of multiple sclerosis (MS) in Austria is almost unknown. We evaluated the prevalence of MS in Austria using data from questionnaires completed by neurologists, comprising information on a total of 1,006 MS patients who attended 30 out-patient specialized clinics nationwide. Additional data were collec...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000065640
更新日期:2002-09-01 00:00:00
abstract::We explored the relationship between amyotrophic lateral sclerosis (ALS) and cigarette smoking in a case-control study conducted in New England from 1993 to 1996. Recently diagnosed ALS cases (n = 109) were recruited from two major referral centers. Population controls (n = 256) were identified by random telephone scr...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000026211
更新日期:1999-01-01 00:00:00
abstract::In neuroepidemiologic research, there are many pitfalls to trap unwary investigators, whether the project is a survey, a case-control study, or some other type of study. We briefly discuss pitfalls relating to: research preliminaries (e.g., failure to decide on study objectives); personnel and training (e.g., deficien...
journal_title:Neuroepidemiology
pub_type: 杂志文章,评审
doi:10.1159/000026153
更新日期:1998-01-01 00:00:00
abstract::Several scores exist to clinically differentiate between ischemic and hemorrhagic stroke, but none has been developed in the emergency situation in which transient ischemic attack (TIA) and cerebral infarction might not yet be clearly distinguished. Information on 540 patients with ischemia (including TIA) or hemorrha...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000048608
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Brain tumours (BT) are one of the most frequent tumour types in young people, although little is known about their risk factors. OBJECTIVE:The objective of the current work was to review and summarize the scientific literature concerning exposure to environmental factors and BT risk in young people (<25 yea...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000500601
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Evidence is emerging that exposure to persistent organic pollutants (POP) is a risk factor for atherosclerosis-related diseases and for diabetes mellitus (DM). We hypothesized that residential proximity to sources of POP will be associated with an increase in hospitalization rates for ischemic stroke (IS) wi...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000316874
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Studies on dyskinesia and Parkinson's syndrome associated with chronic kidney disease or end-stage renal disease (ESRD) have been mainly limited to case reports or case series studies. This population-based study investigated the risk of Parkinson's disease in patients with ESRD. METHODS:From a universal in...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000358921
更新日期:2014-01-01 00:00:00
abstract::The incidence rates of primary nervous system neoplasms in 5 districts (large administrative units) of Western Poland with a relatively homogeneous health care system but some contrasts in economic activity, as well as in 224 communes (smallest administrative units) located within these 5 districts, with a total popul...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110212
更新日期:1985-01-01 00:00:00
abstract::We tested the feasibility of a fully automated brain MRI voxel count technique--automated labeling pathway (ALP)--in a sample of 15 demented and 13 cognitively normal women (age 75-85 years) participating to the Cardiovascular Health Study (CHS). We hypothesized that ALP would replicate well-established findings of th...
journal_title:Neuroepidemiology
pub_type: 临床试验,杂志文章
doi:10.1159/000085140
更新日期:2005-01-01 00:00:00
abstract:AIMS:To evaluate the effect of medical record use on figures for the incidence of dementia and the effect of apolipoprotein E (APOE) polymorphism on this incidence and neuropathologically defined Alzheimer's disease (AD) in very elderly individuals. METHODS:Cognitive functions were examined in a cohort of 328 (92% of ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000090252
更新日期:2006-01-01 00:00:00
abstract::Between 1992 and 2040, the United States nonwhite elderly population is expected to grow from 3.3 to 14.1 million. In order to assess the implications of this increase on the mortality from neurodegenerative diseases in the United States, we used Census Bureau population estimates to formulate projections of the annua...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110377
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:Poorer socioeconomic conditions early in life have been linked with memory, attention and learning deficits in adulthood, as well as with specific areas of educational achievement. It remains unclear, however, whether these distal associations are mediated by more current socioeconomic factors. In this study,...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000325779
更新日期:2011-01-01 00:00:00