Population stratification in a case-control study of brain arteriovenous malformation in Latinos.

Abstract:

BACKGROUND:Genetic association studies conducted in admixed populations may be confounded by population stratification resulting in spurious associations. The purpose of this pilot study was to determine the presence and effect of population stratification in a case-control study of brain arteriovenous malformation (BAVM). METHODS:We tested 83 ancestry informative markers in BAVM cases and healthy controls of self-reported Latino race/ethnicity (n = 294). Individual ancestry estimates (IAE) were obtained using the Structure program, assuming 3 underlying subpopulations. Summary chi(2) tests comparing genotype frequency of ancestry informative markers were used to detect stratification and IAE were included as covariates in logistic regression analysis to account for differences in genetic background. RESULTS:Admixture estimates for Latinos (overall 47% native American, 45% European and 8% African ancestry) revealed heterogeneity between individuals within ancestral groups. The summary chi(2) test was significant (p = 0.005), suggesting ancestral differences between cases and controls. Furthermore, genetic ancestry was associated with frequency differences in a promoter variant in the IL-6 gene (IL-6 -174G>C). On average, subjects with the IL6 -174 GG genotype had 6% greater Native American ancestry (p = 0.023). Age- and sex-adjusted risk of BAVM associated with the IL-6 -174 GG genotype was 1.85 (95% CI 0.99-3.48, p = 0.055), and further adjustments for IAE yielded an OR of 1.96 (95% CI 1.03-3.72, p = 0.039). CONCLUSION:The IL-6 -174G>C polymorphism was associated with increased risk of BAVM among Latinos after accounting for differences in ancestral background. These results suggest subtle, negative confounding and illustrate the importance of addressing population stratification in case-control studies conducted in admixed populations.

journal_name

Neuroepidemiology

journal_title

Neuroepidemiology

authors

Kim H,Hysi PG,Pawlikowska L,Choudhry S,González Burchard E,Kwok PY,Sidney S,McCulloch CE,Young WL

doi

10.1159/000160215

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

224-8

issue

4

eissn

0251-5350

issn

1423-0208

pii

000160215

journal_volume

31

pub_type

杂志文章
  • Primary intracranial tumors in the province of Trento-Italy (1977-1984). Distribution by administrative units.

    abstract::The incidence rate for primary intracranial neoplasms in the province of Trento (Italy) is 8.5/100,000/year, but the figures in the eleven administrative units ('comprensori') are different. The increased rates in C6 Val di Non and C10 Vallagarina are mainly due to the number of malignant tumors in the 45- to 64-year-...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000110825

    authors: Ferrari G,Lovaste MG

    更新日期:1986-01-01 00:00:00

  • Nutritional factors in cerebral aging and dementia: epidemiological arguments for a role of oxidative stress.

    abstract::There is increasing evidence that oxidative stress is involved in cerebral aging and dementia. The objective of this review is to give a progress report on the more recent results of the various epidemiologic cohorts studied for the association between nutrition of older people, the evolution of cognitive performances...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章,评审

    doi:10.1159/000054752

    authors: Deschamps V,Barberger-Gateau P,Peuchant E,Orgogozo JM

    更新日期:2001-02-01 00:00:00

  • Spatial distribution of stroke mortality in Spain, 1975-1986.

    abstract::Cerebrovascular diseases (CVDs) constitute the most frequent cause of death in Spain. In order to identify the geographical pattern of CVD mortality, age- and sex-specific as well as age-adjusted mortality rates (ICD-8,9 rubrics 430-438) were calculated for the period 1975-1986 for each province in the country. Maps w...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000109792

    authors: Barrado-Lanzarote MJ,Almazan-Isla J,Medrano-Albero MJ,de Pedro-Cuesta J

    更新日期:1995-01-01 00:00:00

  • Risk of arterial cardiovascular diseases in patients with multiple sclerosis: a population-based cohort study.

    abstract:BACKGROUND:Patients with multiple sclerosis (MS) may have a higher risk of cardiovascular diseases (CVD) than the general population, but data are limited. METHODS:We conducted a population-based cohort study involving Danish citizens diagnosed with MS (n = 13,963) from 1977 to 2006 and an age- and sex-matched populat...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000320245

    authors: Christiansen CF,Christensen S,Farkas DK,Miret M,Sørensen HT,Pedersen L

    更新日期:2010-01-01 00:00:00

  • Influence of Pre-Existing Mild Cognitive Impairment and Dementia on Post-Stroke Mortality. The Dijon Stroke Registry.

    abstract:OBJECTIVE:We assessed the association between pre-stroke cognitive status and 90-day case-fatality. METHODS:Patients with ischemic stroke (IS) or spontaneous intracerebral hemorrhage (ICH) were prospectively identified among residents of Dijon, France, between 2013 and 2015, using a population-based registry. Associat...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000497614

    authors: Graber M,Garnier L,Mohr S,Delpont B,Blanc-Labarre C,Vergely C,Giroud M,Béjot Y

    更新日期:2020-01-01 00:00:00

  • Prevalence of multiple sclerosis in Austria. Results of a nationwide survey.

    abstract::The epidemiology of multiple sclerosis (MS) in Austria is almost unknown. We evaluated the prevalence of MS in Austria using data from questionnaires completed by neurologists, comprising information on a total of 1,006 MS patients who attended 30 out-patient specialized clinics nationwide. Additional data were collec...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000065640

    authors: Baumhackl U,Eibl G,Ganzinger U,Hartung HP,Mamoli B,Pfeiffer KP,Fazekas F,Vass K,Austrian MS Study Committee.

    更新日期:2002-09-01 00:00:00

  • Generalized neuropathy in Taiwan: an etiologic survey.

    abstract::From July 1988 to June 1989, the etiology was registered of 520 patients with generalized neuropathy in 5 neurological centers in Taiwan. The neuropathy was diabetic in 256 cases (49.23%), alcoholic in 45 (8.65%), inflammatory in 34 (6.53%; including 21 with acute inflammatory demyelinating polyneuropathy, 12 with chr...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000110326

    authors: Lin KP,Kwan SY,Chen SY,Chen SS,Yeung KB,Chia LG,Wu ZA

    更新日期:1993-01-01 00:00:00

  • Multicenter transversal two-phase study to determine a national prevalence of epilepsy in Algeria.

    abstract:BACKGROUND/AIMS:The prevalence of epilepsy in Algeria is unknown. The aims of this multicenter transversal study were to determine the national prevalence and clinical characteristics of epilepsy in the Algerian population. METHODS:This two-phase study was conducted in 5 circumscriptions and included 8,046 subjects ag...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000339637

    authors: Moualek D,Pacha LA,Abrouk S,Kediha MI,Nouioua S,Aissa LA,Bellatache M,Belarbi S,Slimani S,Khennouf H,Fellahi L,El Amine Hamimed M,Benali N,Chekkour MC,Maamoun R,Dameche R,Assami S,Tazir M

    更新日期:2012-01-01 00:00:00

  • Explanation and Elaboration of the Standards of Reporting of Neurological Disorders Checklist: A Guideline for the Reporting of Incidence and Prevalence Studies in Neuroepidemiology.

    abstract:BACKGROUND:Incidence and prevalence studies of neurological disorders play an extremely important role in hypothesis-generation, assessing the burden of disease and planning of health services. However, the assessment of disease estimates is hindered by the poor quality of reporting for such studies. We developed the S...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000439132

    authors: Bennett DA,Brayne C,Feigin VL,Barker-Collo S,Brainin M,Davis D,Gallo V,Jetté N,Karch A,Kurtzke JF,Lavados PM,Logroscino G,Nagel G,Preux PM,Rothwell PM,Svenson LW

    更新日期:2015-01-01 00:00:00

  • The prevalence of cognitive impairment among nursing home residents in Taipei, Taiwan.

    abstract::A random sample of nursing home residents over 65 years of age were interviewed. Two hundred ninety-two participants received the Short Portable Mental Status Questionnaire. Two hundred eleven were unable to answer the questionnaire, but their caregivers provided information about their daily activities and performanc...

    journal_title:Neuroepidemiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000026166

    authors: Wu SC,Ke D,Su TL

    更新日期:1998-01-01 00:00:00

  • Incidence of dementia in Melton Mowbray: a proposed study and its problems.

    abstract::This paper describes a proposed study to investigate the incidence of dementia in a population of over 75 year olds in Melton Mowbray, Leicestershire, England. The study population (n = 438) underwent a detailed psychiatric assessment using the Cambridge Examination for Mental Disorders of the Elderly (CAMDEX) as the ...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000110980

    authors: Jagger C,Clarke M,Anderson J

    更新日期:1992-01-01 00:00:00

  • Sociodemographic factors and primary headache syndromes in a Saudi community.

    abstract:BACKGROUND AND PURPOSE:There is increasing evidence that the pathophysiologic mechanisms are different between migraine and tension-type headache. The aim of the study was to determine possible sociodemographic differences in Saudi Arabia subjects with headache. METHODOLOGY:A community-based door-to-door survey with i...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000109670

    authors: Abdul Jabbar M,Ogunniyi A

    更新日期:1997-01-01 00:00:00

  • Increased risk of Parkinson's disease in patients with end-stage renal disease: a retrospective cohort study.

    abstract:BACKGROUND:Studies on dyskinesia and Parkinson's syndrome associated with chronic kidney disease or end-stage renal disease (ESRD) have been mainly limited to case reports or case series studies. This population-based study investigated the risk of Parkinson's disease in patients with ESRD. METHODS:From a universal in...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000358921

    authors: Wang IK,Lin CL,Wu YY,Chou CY,Lin SY,Liu JH,Yen TH,Huang CC,Sung FC

    更新日期:2014-01-01 00:00:00

  • Antecedent events in amyotrophic lateral sclerosis: do they influence clinical onset and progression?

    abstract::Risk factors for amyotrophic lateral sclerosis (ALS) such as country of residence, hard labour, intense athletic activities, heavy metal and pet exposure, skeletal trauma, surgical procedures, malignancies, and recurrent infectious disease were investigated in 77 patients and 80 controls, matching the cases for select...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000110782

    authors: Provinciali L,Giovagnoli AR

    更新日期:1990-01-01 00:00:00

  • Stroke and ischemic heart disease mortality trends in Brazil from 1979 to 1996.

    abstract::Stroke and ischemic heart disease (IHD) mortality rates were analyzed in Brazilian subjects older than 30 years of age from 1979 to 1996. Population estimates were based on census surveys. Mortality data were obtained from the Ministry of Health. For stroke, the age-adjusted death rate (ADR) dropped from 200 to 164 an...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000069893

    authors: de Padua Mansur A,de Fátima Marinho do Souza M,Favarato D,Avakian SD,Machado César LA,Mendes Aldrigui J,Franchini Ramires JA

    更新日期:2003-05-01 00:00:00

  • Population-based epidemiological study of neurological diseases in Taiwan: I. Creutzfeldt-Jakob disease and multiple sclerosis.

    abstract:BACKGROUND:The purpose of the study is to investigate the epidemiology of Creutzfeldt-Jakob disease (CJD) and multiple sclerosis (MS) in Taiwan. METHODS:Cases of CJD and MS were identified from the National Health Insurance Research Database from January 2000 to December 2005. Age- and sex-specific incidences of these...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000229779

    authors: Lai CH,Tseng HF

    更新日期:2009-01-01 00:00:00

  • Case-control study of Meige's syndrome. Result of a pilot study.

    abstract::A pilot case-control study was conducted to identify possible risk factors for Meige's syndrome. Patients with Meige's syndrome and age- and sex-matched controls suffering from other neurological diseases were recruited from the Movement Disorders Clinic and Neurology Outpatient Department of the All India Insititute ...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000026265

    authors: Behari M,Sharma AK,Changkakoti S,Sharma N,Pandey RM

    更新日期:2000-09-01 00:00:00

  • Changes in Mini-Mental State Exam in community-dwelling older persons over 6 years: relationship to health and neuropsychological measures.

    abstract::Although cognitive screening test scores change with advanced age, the significance of these changes (particularly decline in score) needs to be defined in terms of general health and neuropsychological functioning. Such analysis was undertaken in a subgroup of 287 healthy older men (mean age at baseline = 70.7 years)...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000067113

    authors: Eslinger PJ,Swan GE,Carmelli D

    更新日期:2003-01-01 00:00:00

  • The prevalence and severity of white matter lesions, their relationship with age, ethnicity, gender, and cardiovascular disease risk factors: the ARIC Study.

    abstract::White matter lesions (WMLs) detected by cerebral magnetic resonance imaging (MRI) are putatively a consequence of cerebral hypoperfusion or ischemia. We investigated the prevalence, severity and correlates of WMLs in a population-based sample of 1,920 African-American and European-American men and women aged 55-72 yea...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000368814

    authors: Liao D,Cooper L,Cai J,Toole J,Bryan N,Burke G,Shahar E,Nieto J,Mosley T,Heiss G

    更新日期:1997-01-01 00:00:00

  • Validity and reliability of the 'Ten Questions' questionnaire for detecting moderate to severe neurological impairment in children aged 6-9 years in rural Kenya.

    abstract:BACKGROUND:The 'Ten Questions' Questionnaire (TQQ) is used to detect severe neurological impairment in children living in resource-poor countries. Its usefulness has been established in Asia and the Caribbean, but there are a few published studies from Africa. We evaluated the TQQ as part of a larger study of neurologi...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000073977

    authors: Mung'ala-Odera V,Meehan R,Njuguna P,Mturi N,Alcock K,Carter JA,Newton CR

    更新日期:2004-01-01 00:00:00

  • Hepatitis B vaccination and first central nervous system demyelinating event: a case-control study.

    abstract:OBJECTIVE:To investigate the relationship between hepatitis B (HB) vaccination and a first central nervous system (CNS) demyelinating event in adults. METHODS:In 1998, we conducted a multicentre, hospital-based case-control study which enrolled 402 cases of first CNS demyelinating event occurring between 1994 and 1995...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000059520

    authors: Touzé E,Fourrier A,Rue-Fenouche C,Rondé-Oustau V,Jeantaud I,Bégaud B,Alpérovitch A

    更新日期:2002-07-01 00:00:00

  • Stroke in China (Sino-MONICA-Beijing study) 1984-1986.

    abstract::We present here the results of the Sino-MONICA-Beijing stroke study based on 700,000 Beijing residents in 1984-1986. To compare incidence rates for stroke with other communities and countries, we adopted the criteria of the WHO Collaborative Study of 17 centers which used the same definition and methodology as was use...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000110902

    authors: Chen D,Román GC,Wu GX,Wu ZS,Yao CH,Zhang M,Hirsch RP

    更新日期:1992-01-01 00:00:00

  • Spatial Assessment of the Association between Long-Term Exposure to Environmental Factors and the Occurrence of Amyotrophic Lateral Sclerosis in Catalonia, Spain: A Population-Based Nested Case-Control Study.

    abstract:BACKGROUND:It is believed that an interaction between genetic and non-genetic factors may be involved in the development of amyotrophic lateral sclerosis (ALS). With the exception of exposure to agricultural chemicals like pesticides, evidence of an association between environmental risk factors and ALS is inconsistent...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000489664

    authors: Povedano M,Saez M,Martínez-Matos JA,Barceló MA

    更新日期:2018-01-01 00:00:00

  • The management approaches to dyskinesia vary from country to country.

    abstract::Many Parkinson's disease (PD) patients treated with levodopa develop motor fluctuations and/or dyskinesia. This large, retrospective study was conducted to compare the prevalence and treatment of dyskinesia in PD patients in seven countries. A total of 380 physicians were interviewed and completed patient record forms...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000111578

    authors: Woitalla D,Mueller T,Russ H,Hock K,Haeger DA

    更新日期:2007-01-01 00:00:00

  • Epidemiology of Amyotrophic Lateral Sclerosis in the Republic of Cyprus: A 25-Year Retrospective Study.

    abstract:INTRODUCTION:Amyotrophic lateral sclerosis (ALS) is a rare, rapidly progressive neurodegenerative disease. Despite wide variability in the incidence and prevalence of ALS, there is evidence of positive temporal trends and an increase in incidence with age. The aim of this study was to conduct a detailed epidemiological...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000477126

    authors: Demetriou CA,Hadjivasiliou PM,Kleopa KA,Christou YP,Leonidou E,Kyriakides T,Zamba-Papanicolaou E

    更新日期:2017-01-01 00:00:00

  • Factors influencing long-term survival and disability among three-month stroke survivors.

    abstract::216 survivors of acute stroke were studied 3 months postictus to determine predictors of long-term survival and disability 20 months after the initial stroke. Factors predicting mortality were, in order of importance, old age, a history of ischaemic heart disease, low mental-test score, low serum cholesterol concentra...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000110924

    authors: Woo J,Kay R,Yuen YK,Nicholls MG

    更新日期:1992-01-01 00:00:00

  • Prevalence of Parkinson's disease in Bulgarian Gypsies.

    abstract::We studied the prevalence of Parkinson's disease (PD) in Gypsies and Caucasians in Bulgaria. Cases were ascertained by examination in a clinic, a screening questionnaire and a door-to-door survey in a region of Sofia, Bulgaria. The prevalence of PD in the Gypsies was found to be 16/100,000 based on 1 case compared to ...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000026257

    authors: Milanov I,Kmetski TS,Lyons KE,Koller WC

    更新日期:2000-07-01 00:00:00

  • Risk factors for multiple sclerosis in Kuwait: a population-based case-control study.

    abstract::Multiple sclerosis (MS) is a chronic and progressively disabling inflammatory autoimmune disorder of the central nervous system. MS has a multifactorial etiology and is triggered by environmental factors in individuals with complex genetic risk profiles. The epidemiology of MS changes with the spatial and temporal dis...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000341240

    authors: Al-Afasy HH,Al-Obaidan MA,Al-Ansari YA,Al-Yatama SA,Al-Rukaibi MS,Makki NI,Suresh A,Akhtar S

    更新日期:2013-01-01 00:00:00

  • Resting Heart Rate Is Not Associated with Cognitive Function.

    abstract:AIMS:In order to examine the hypothesis that elevated resting heart rate (RHR) is associated with impaired cognitive score, we investigated the relationship between RHR and cognitive score in middle-aged, elderly and old Danish subjects from the general population. METHODS:Composite cognitive scores derived from the r...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000487802

    authors: Wod M,Jensen MT,Galatius S,Hjelmborg JB,Jensen GB,Christensen K

    更新日期:2018-01-01 00:00:00

  • The prevalence of hereditary spastic paraplegia and the occurrence of SPG4 mutations in Estonia.

    abstract:BACKGROUND:Hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneous disorder, with a variable reported prevalence ranging from 0.5 to 12 per 100,000. The aim of this retrospective study was to evaluate the prevalence of HSP and estimate the percentage of SPG4 mutations in the Estonian populatio...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000177033

    authors: Braschinsky M,Luus SM,Gross-Paju K,Haldre S

    更新日期:2009-01-01 00:00:00