Abstract:
:Although cognitive screening test scores change with advanced age, the significance of these changes (particularly decline in score) needs to be defined in terms of general health and neuropsychological functioning. Such analysis was undertaken in a subgroup of 287 healthy older men (mean age at baseline = 70.7 years) from the Western Collaborative Group Study, an ongoing cardiovascular and aging research project. Time from baseline to follow-up study averaged 6.0 years (SD = 0.5 years). Mini-Mental State Examination (MMSE) scores indicated that 15% of participants declined by three or more points (a 1+ standard deviation change among all change scores), 5% of participants improved by three or more points, and 80% of the sample remained within two points of their initial score. In health terms, decliners were significantly older, less active at follow-up, rated their health more poorly, and reported more depressive symptoms than non-decliners. Decliners also performed more poorly on several neuropsychological tests administered at follow-up. Results suggest that a decline of three or more points on the MMSE in community-dwelling, older persons without acute illness may signify important changes in health and cognition.
journal_name
Neuroepidemiologyjournal_title
Neuroepidemiologyauthors
Eslinger PJ,Swan GE,Carmelli Ddoi
10.1159/000067113subject
Has Abstractpub_date
2003-01-01 00:00:00pages
23-30issue
1eissn
0251-5350issn
1423-0208pii
67113journal_volume
22pub_type
杂志文章abstract:BACKGROUND:The purpose of the study is to investigate the epidemiology of Creutzfeldt-Jakob disease (CJD) and multiple sclerosis (MS) in Taiwan. METHODS:Cases of CJD and MS were identified from the National Health Insurance Research Database from January 2000 to December 2005. Age- and sex-specific incidences of these...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000229779
更新日期:2009-01-01 00:00:00
abstract::The Global Burden of Disease (GBD) study is a long-standing effort to report consistent and comprehensive measures of disease burden for the world. In this paper, we describe the methods used to estimate the global burden of stroke for the GBD 2013 study. Pathologic subtypes of stroke are modeled separately for two mu...
journal_title:Neuroepidemiology
pub_type: 杂志文章,评审
doi:10.1159/000441083
更新日期:2015-01-01 00:00:00
abstract::Between 1992 and 2040, the United States nonwhite elderly population is expected to grow from 3.3 to 14.1 million. In order to assess the implications of this increase on the mortality from neurodegenerative diseases in the United States, we used Census Bureau population estimates to formulate projections of the annua...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110377
更新日期:1994-01-01 00:00:00
abstract::The multiple sclerosis (MS) prevalence rates in five districts of Bulgaria were compared with some geographic and climatic factors. In Bulgaria the latitude seems not to be a factor influencing the MS distribution. As to the climatic factors, a negative correlation was obtained between MS prevalence and mean annual su...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110106
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Evidence is emerging that exposure to persistent organic pollutants (POP) is a risk factor for atherosclerosis-related diseases and for diabetes mellitus (DM). We hypothesized that residential proximity to sources of POP will be associated with an increase in hospitalization rates for ischemic stroke (IS) wi...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000316874
更新日期:2010-01-01 00:00:00
abstract::All death certificates with amyotrophic lateral sclerosis (ALS) or motor neuron disease (MND) as the primary or underlying cause occurring among Kentucky residents between 1964 and 1984 were manually reviewed. Geographic variability within Kentucky was evident for three intervals, 1964-1967, 1968-1978, and 1979-1984, ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110168
更新日期:1989-01-01 00:00:00
abstract::From July 1988 to June 1989, the etiology was registered of 520 patients with generalized neuropathy in 5 neurological centers in Taiwan. The neuropathy was diabetic in 256 cases (49.23%), alcoholic in 45 (8.65%), inflammatory in 34 (6.53%; including 21 with acute inflammatory demyelinating polyneuropathy, 12 with chr...
journal_title:Neuroepidemiology
pub_type: 杂志文章,多中心研究
doi:10.1159/000110326
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Guillain-Barré syndrome (GBS) is a potentially life-threatening disease that typically occurs after a preceding infectious disease. An accurate estimation of GBS incidence would be useful for investigating the potential causal relationships between risk factors and GBS. Here we described the nationwide incid...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000430917
更新日期:2015-01-01 00:00:00
abstract::A total of 186 cases of motor neuron disease (MND) was identified in two Danish counties during the period 1974-1986. The average annual incidence rate was 1.4/100,000 population, and the male:female ratio of incidence rates was 1.5. Mean age at diagnosis was 64.3 +/- 10.0 years. The incidence rates increased signific...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110177
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneous disorder, with a variable reported prevalence ranging from 0.5 to 12 per 100,000. The aim of this retrospective study was to evaluate the prevalence of HSP and estimate the percentage of SPG4 mutations in the Estonian populatio...
journal_title:Neuroepidemiology
pub_type: 杂志文章,多中心研究
doi:10.1159/000177033
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:The clinical characteristics of multiple sclerosis (MS) are not well defined in Hispanic populations. We hypothesized that disease presentation in Hispanic white (HW) patients will be different from non-Hispanic white (NHW) patients given their ancestral background and reported lower disease prevalence. This ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000431375
更新日期:2015-01-01 00:00:00
abstract::A comparison of epidemiological and clinical features of trigeminal neuralgia (TN) and glossopharyngeal neuralgia (GN) in Rochester, Minn., reveals several differences. The overall age- and sex-adjusted annual incidence rates were significantly higher for TN than for GN (4.7 vs. 0.8 per 100,000 population). The TN:GN ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110284
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Mild cognitive impairment (MCI) has been suggested as a term for a boundary area between normal aging and dementia. This study was designed to determine the prevalence of MCI in the elderly in the Hebei province, China, and explore its related factors. METHODS:Participants included 2,601 community-dwelling ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000357374
更新日期:2014-01-01 00:00:00
abstract::A pilot case-control study was conducted to identify possible risk factors for Meige's syndrome. Patients with Meige's syndrome and age- and sex-matched controls suffering from other neurological diseases were recruited from the Movement Disorders Clinic and Neurology Outpatient Department of the All India Insititute ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000026265
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND/AIMS:Neurosarcoidosis is a rare condition with serious health consequences. However, little is known about clinical characteristics and outcome of neurosarcoidosis in the community setting. METHODS:Patients with neurosarcoidosis were identified from a previously described cohort of patients with incident sa...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000477300
更新日期:2017-01-01 00:00:00
abstract::Multiple sclerosis (MS) is a chronic and progressively disabling inflammatory autoimmune disorder of the central nervous system. MS has a multifactorial etiology and is triggered by environmental factors in individuals with complex genetic risk profiles. The epidemiology of MS changes with the spatial and temporal dis...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000341240
更新日期:2013-01-01 00:00:00
abstract::We tested the feasibility of a fully automated brain MRI voxel count technique--automated labeling pathway (ALP)--in a sample of 15 demented and 13 cognitively normal women (age 75-85 years) participating to the Cardiovascular Health Study (CHS). We hypothesized that ALP would replicate well-established findings of th...
journal_title:Neuroepidemiology
pub_type: 临床试验,杂志文章
doi:10.1159/000085140
更新日期:2005-01-01 00:00:00
abstract::Cerebrovascular diseases (CVDs) constitute the most frequent cause of death in Spain. In order to identify the geographical pattern of CVD mortality, age- and sex-specific as well as age-adjusted mortality rates (ICD-8,9 rubrics 430-438) were calculated for the period 1975-1986 for each province in the country. Maps w...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000109792
更新日期:1995-01-01 00:00:00
abstract::Transcranial Doppler ultrasonography allows the non-invasive assessment of cerebral haemodynamics. Data on the frequency distribution of these parameters in the oldest old are scarce, which makes a distinction between physiological and pathophysiological ageing difficult. We studied the relation between cerebral haemo...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000078503
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Familial aggregation has been shown for Alzheimer's disease (AD) and Parkinson's disease (PD) separately, and it has been hypothesized that these diseases also coaggregate in families. METHODS:The authors investigated familial coaggregation of AD and PD by conducting a systematic review and meta-analysis. P...
journal_title:Neuroepidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000355452
更新日期:2014-01-01 00:00:00
abstract::In this report we describe the establishment of a Neuro-Oncology Register (NOR) at the University Hospital of Maastricht, The Netherlands. The register includes data on numbers and types of primary central nervous system (CNS) tumours and neurological complications of systemic cancer. One of the objectives of the regi...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110939
更新日期:1992-01-01 00:00:00
abstract::In the past several years, a substantial amount of new information on the epidemiology and pathophysiology of diabetes and vascular disease has become available. Autopsy studies suggest that diabetic patients are susceptible to cerebral small-artery disease and lacunar infarction and may be at risk for large-artery at...
journal_title:Neuroepidemiology
pub_type: 杂志文章,评审
doi:10.1159/000026190
更新日期:1999-01-01 00:00:00
abstract:AIMS:To evaluate the effect of medical record use on figures for the incidence of dementia and the effect of apolipoprotein E (APOE) polymorphism on this incidence and neuropathologically defined Alzheimer's disease (AD) in very elderly individuals. METHODS:Cognitive functions were examined in a cohort of 328 (92% of ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000090252
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Repetitive head trauma is an identified risk factor for Alzheimer's disease (AD). The violence in wife assault is repetitive and targets the head. This association provides a rationale for studying the relationship between spousal abuse and AD. DESIGN:To preliminarily evaluate the possibility of an increase...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000093894
更新日期:2006-01-01 00:00:00
abstract::Spanish-language versions of standardized questionnaires are important for facilitating inclusion of Hispanic populations in epidemiologic, genetic, and clinical studies. We aimed at producing a culturally adapted Spanish translation of the Questionnaire for Verifying Stroke-free Status (QVSS), an instrument used to s...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000079949
更新日期:2004-09-01 00:00:00
abstract::The epsilon 4 allele of the apolipoprotein E (apoE) is associated with Alzheimer's disease (AD) and also with elevated serum total cholesterol and low-density lipoprotein levels. However, the interrelationships between apoE genotype, plasma cholesterol levels and AD risk have been studied very little. We examined the ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000026149
更新日期:1998-01-01 00:00:00
abstract::Most available data on the prognosis of epileptic seizures come from hospital-based clinics in which patients with chronic or severe disease are over-represented. The National General Practice Study of Epilepsy and Epileptic Seizures is a large prospective community-based study of people with newly diagnosed seizures ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110186
更新日期:1989-01-01 00:00:00
abstract::Several scores exist to clinically differentiate between ischemic and hemorrhagic stroke, but none has been developed in the emergency situation in which transient ischemic attack (TIA) and cerebral infarction might not yet be clearly distinguished. Information on 540 patients with ischemia (including TIA) or hemorrha...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000048608
更新日期:2002-01-01 00:00:00
abstract::We performed a community-based study on a cohort of 221 stroke patients followed for 3 years. In this paper, we tried to answer the following questions: Is the risk of dying increased throughout the first 3 years after stroke? What are the causes of death after the 1st month? What factors at stroke onset are independe...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000069410
更新日期:1999-01-01 00:00:00
abstract::We carried out a door-to-door survey in rural areas of the Cordillera Province, Bolivia, to determine the prevalence of the most common neurological diseases in a sample of about 10,000 inhabitants. A team of non-doctor health workers administered a standard screening instrument for neurological diseases, a slightly m...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000048624
更新日期:2002-03-01 00:00:00