Genetic analysis of late-onset diseases using first-degree relatives.

abstract：:Trends of multiple sclerosis mortality in Spain from 1951 to 1997 are examined. Age-adjusted mortality strongly decreased from 3.08 per 100,000 women in 1951-1967 to 0.59 in 1968-1980 (similar figures were obtained for men). This decrease seems to be due to an artifact produced by changes in codification of causes of ...

journal_title：Neuroepidemiology

authors： Llorca J,Guerrero-Alonso P,Prieto-Salceda D

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:We validated a new method of identifying patients with incident myasthenia in automated Danish registers for the purpose of conducting epidemiological studies of the disorder. METHODS:For residents of a Danish county (population 484,862) in 1993-2008, we identified any hospital contacts coded for myasthenia...

journal_title：Neuroepidemiology

authors： Pedersen EG,Hallas J,Hansen K,Jensen PE,Gaist D

更新日期：2011-01-01 00:00:00

abstract：:The multiple sclerosis (MS) prevalence rates in five districts of Bulgaria were compared with some geographic and climatic factors. In Bulgaria the latitude seems not to be a factor influencing the MS distribution. As to the climatic factors, a negative correlation was obtained between MS prevalence and mean annual su...

journal_title：Neuroepidemiology

authors： Kalafatova O

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:Using data from a recent report that indicated a 2-fold higher risk of amyotrophic lateral sclerosis (ALS) among veterans of the 1991 Gulf War, we applied capture-recapture methodology to estimate possible under-ascertainment of ALS cases among deployed and non-deployed military personnel who were on active d...

journal_title：Neuroepidemiology

authors： Coffman CJ,Horner RD,Grambow SC,Lindquist J,VA Cooperative Studies Program Project #500.

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND/AIMS:Brain tumors are the second most common pediatric malignancy. The literature suggests that one of the most common subtypes of malignant childhood brain tumor, medulloblastoma, has some seasonal variation in incidence by month of birth. METHODS:Data from cases in the Central Brain Tumor Registry of the ...

journal_title：Neuroepidemiology

authors： Hoffman S,Schellinger KA,Propp JM,McCarthy BJ,Campbell RT,Davis FG

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:White matter hyperintensities (WMHs) are a risk factor for stroke. Their etiology is considered to be cerebral microvascular abnormality. However, the association between WMHs and arteriosclerosis is not yet clear. The aim of this hospital-based cohort study was to identify the arteriosclerotic characteristi...

journal_title：Neuroepidemiology

authors： Saji N,Shimizu H,Kawarai T,Tadano M,Kita Y,Yokono K

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Limited epidemiological data exist about amyotrophic lateral sclerosis (ALS) in the United States (US). The Agency for Toxic Substances and Disease Registry maintains the National ALS Registry and funded state and metropolitan surveillance projects to obtain reliable, timely information about ALS in defined ...

journal_title：Neuroepidemiology

authors： Jordan H,Fagliano J,Rechtman L,Lefkowitz D,Kaye W

更新日期：2014-01-01 00:00:00

abstract：:In the past several years, a substantial amount of new information on the epidemiology and pathophysiology of diabetes and vascular disease has become available. Autopsy studies suggest that diabetic patients are susceptible to cerebral small-artery disease and lacunar infarction and may be at risk for large-artery at...

journal_title：Neuroepidemiology

authors： Lukovits TG,Mazzone TM,Gorelick TM

更新日期：1999-01-01 00:00:00

abstract：:In this report we describe the establishment of a Neuro-Oncology Register (NOR) at the University Hospital of Maastricht, The Netherlands. The register includes data on numbers and types of primary central nervous system (CNS) tumours and neurological complications of systemic cancer. One of the objectives of the regi...

journal_title：Neuroepidemiology

authors： Lassouw GM,Twijnstra A,Schouten LJ,van de Pol M

更新日期：1992-01-01 00:00:00

abstract：:The purpose of our study was to determine the incidence of stroke, case-fatality rate and disability at 1 year in the Valley of Aosta (Italy) in the years 2004 and 2005. All suspected strokes occurring between January 1, 2004, and December 31, 2005, in the resident population of the Valley of Aosta were identified acc...

journal_title：Neuroepidemiology

authors： Corso G,Bottacchi E,Giardini G,De la Pierre F,Meloni T,Pesenti Campagnoni M,Ponzetti C,Veronese Morosini M

更新日期：2009-01-01 00:00:00

abstract：:The recognition that cognitive impairment of vascular origin is not limited to multi-infarct dementia has led to the development of several sets of new criteria for vascular dementia (VaD). We set out to define the spectrum of disease in patients presenting with vascular cognitive impairment (VCI). Of 412 patients con...

journal_title：Neuroepidemiology

authors： Rockwood K,Howard K,MacKnight C,Darvesh S

更新日期：1999-01-01 00:00:00

abstract：:We report anticipation in an extensive sample of myotonic dystrophy (MyD) kindreds taken from an epidemiological survey recently conducted in Guipúzcoa, Spain. Analysis of the parent-child pairs ascertained showed a mean anticipation of 2.86 decades (range 0-6). Greater anticipation occurred when the transmissor paren...

journal_title：Neuroepidemiology

authors： López de Munain A,Blanco A,Emparanza JI,Martí Massó JF,Cobo A,Basauri B,Martorell L,Baiget M,Martínez Lage JM

更新日期：1994-01-01 00:00:00

abstract：:An increased risk for first-degree relatives (FDR) of glioma patients has previously been observed. The novel objective of this study was to investigate differences in familial risk among FDR of low-grade glioma (LGG) and high-grade glioma (HGG) cases, respectively. Two cohorts were constructed, one from 15,321 FDR of...

journal_title：Neuroepidemiology

authors： Malmer B,Henriksson R,Grönberg H

更新日期：2002-11-01 00:00:00

abstract：:Although cognitive screening test scores change with advanced age, the significance of these changes (particularly decline in score) needs to be defined in terms of general health and neuropsychological functioning. Such analysis was undertaken in a subgroup of 287 healthy older men (mean age at baseline = 70.7 years)...

journal_title：Neuroepidemiology

authors： Eslinger PJ,Swan GE,Carmelli D

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Recent interest in antihypertensive agents, especially calcium channel blockers, has been sparked by the notion that these medications may be neuroprotective. A modest literature, with mixed results, has examined whether these medications might lower the odds or risk of Parkinson's disease (PD) or dementia. ...

journal_title：Neuroepidemiology

authors： Louis ED,Benito-León J,Bermejo-Pareja F,Neurological Disorders in Central Spain (NEDICES) Study Group.

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Hereditary ataxias (HA) comprise a group of genetically heterogeneous rare diseases. As important public health problems to be monitored, this study analyses the morbimortality of HA in Spain. METHODS:Data were extracted from the national death index (1981-2008), using the International Classification of Di...

journal_title：Neuroepidemiology

authors： Alonso V,Villaverde-Hueso A,Hens MJ,Morales-Piga A,Abaitua I,Posada de la Paz M

更新日期：2013-01-01 00:00:00

abstract：:Transcranial Doppler ultrasonography allows the non-invasive assessment of cerebral haemodynamics. Data on the frequency distribution of these parameters in the oldest old are scarce, which makes a distinction between physiological and pathophysiological ageing difficult. We studied the relation between cerebral haemo...

journal_title：Neuroepidemiology

authors： Bakker SL,de Leeuw FE,den Heijer T,Koudstaal PJ,Hofman A,Breteler MM

更新日期：2004-07-01 00:00:00

abstract：:The advent of new laboratory methods and noninvasive imaging modalities has extended the diagnostic possibilities in normal individuals. This article elaborates the new options for the assessment of stroke risk offered by these techniques. In this context we present the Austrian Stroke Prevention Study, which is the f...

journal_title：Neuroepidemiology

authors： Schmidt R,Lechner H,Fazekas F,Niederkorn K,Reinhart B,Grieshofer P,Horner S,Offenbacher H,Koch M,Eber B

更新日期：1994-01-01 00:00:00

abstract：:Seizures precipitated by the stimulus of hot water known as 'hot water epilepsy' (HWE) have been commonly reported from South India. The present report outlines certain descriptive epidemiological aspects of 78 cases from two rural satellite clinics of National Institute of Mental Health and Neuro Sciences (NIMHANS), ...

journal_title：Neuroepidemiology

authors： Gururaj G,Satishchandra P

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Hereditary cerebellar ataxias (HCA) and hereditary spastic paraplegias (HSP) are two groups of neurodegenerative disorders that usually present with progressive gait impairment, often leading to permanent disability. Advances in genetic research in the last decades have improved their diagnosis and brought n...

journal_title：Neuroepidemiology

authors： Ruano L,Melo C,Silva MC,Coutinho P

更新日期：2014-01-01 00:00:00

abstract：:There is increasing evidence that oxidative stress is involved in cerebral aging and dementia. The objective of this review is to give a progress report on the more recent results of the various epidemiologic cohorts studied for the association between nutrition of older people, the evolution of cognitive performances...

journal_title：Neuroepidemiology

authors： Deschamps V,Barberger-Gateau P,Peuchant E,Orgogozo JM

更新日期：2001-02-01 00:00:00

abstract：:This paper describes a proposed study to investigate the incidence of dementia in a population of over 75 year olds in Melton Mowbray, Leicestershire, England. The study population (n = 438) underwent a detailed psychiatric assessment using the Cambridge Examination for Mental Disorders of the Elderly (CAMDEX) as the ...

journal_title：Neuroepidemiology

authors： Jagger C,Clarke M,Anderson J

更新日期：1992-01-01 00:00:00

abstract：:We tested the feasibility of a fully automated brain MRI voxel count technique--automated labeling pathway (ALP)--in a sample of 15 demented and 13 cognitively normal women (age 75-85 years) participating to the Cardiovascular Health Study (CHS). We hypothesized that ALP would replicate well-established findings of th...

journal_title：Neuroepidemiology

authors： Rosano C,Becker J,Lopez O,Lopez-Garcia P,Carter CS,Newman A,Kuller L,Aizenstein H

更新日期：2005-01-01 00:00:00

abstract：:The black Caribbean population continues to grow in the US and little is known about stroke etiologies in that community. We examined stroke subtypes in 175 consecutive Haitian-born patients living in Miami, admitted for acute stroke. Ischemic stroke was diagnosed in 72%. Small vessel occlusion was the most frequent s...

journal_title：Neuroepidemiology

authors： Koch S,Pabon D,Rabinstein AA,Chirinos J,Romano JG,Forteza A

更新日期：2005-01-01 00:00:00

abstract：:A strategy for assessing the clinical importance of statistically significant treatment benefits in recent dementia drug trials is proposed. Traditional criteria for the assessment of valid inferences are helpful: the more likely the treatment effects are valid, the greater the chance that they will be clinically impo...

journal_title：Neuroepidemiology

authors： Rockwood K,MacKnight C

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND/AIMS:Cognitive decline is a defining feature of dementia. We sought to determine if a single baseline cognitive test score or change in test score over time is more strongly associated with risk of dementia hospitalization. We also sought to compare short- and long-term dementia risk. METHODS:Prospective co...

journal_title：Neuroepidemiology

authors： Schneider AL,Gottesman RF,Mosley T,Alonso A,Knopman DS,Coresh J,Sharrett AR,Selvin E

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneous disorder, with a variable reported prevalence ranging from 0.5 to 12 per 100,000. The aim of this retrospective study was to evaluate the prevalence of HSP and estimate the percentage of SPG4 mutations in the Estonian populatio...

journal_title：Neuroepidemiology

authors： Braschinsky M,Luus SM,Gross-Paju K,Haldre S

更新日期：2009-01-01 00:00:00

abstract：:According to studies done before 1980, the multiple sclerosis (MS) prevalence rate in Italy ranged from 7.2 to 27.1 cases per 100,000 inhabitants. More recent work has consistently put the MS prevalence rate to over 30 cases per 100,000 inhabitants. If these recent data are confirmed in the future, Italy can no longer...

journal_title：Neuroepidemiology

authors： Sironi L,Mamoli A,D'Alessandro G,Camerlingo M,Bottacchi E

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Studies on dyskinesia and Parkinson's syndrome associated with chronic kidney disease or end-stage renal disease (ESRD) have been mainly limited to case reports or case series studies. This population-based study investigated the risk of Parkinson's disease in patients with ESRD. METHODS:From a universal in...

journal_title：Neuroepidemiology

authors： Wang IK,Lin CL,Wu YY,Chou CY,Lin SY,Liu JH,Yen TH,Huang CC,Sung FC

更新日期：2014-01-01 00:00:00

abstract：:A random sample of nursing home residents over 65 years of age were interviewed. Two hundred ninety-two participants received the Short Portable Mental Status Questionnaire. Two hundred eleven were unable to answer the questionnaire, but their caregivers provided information about their daily activities and performanc...

journal_title：Neuroepidemiology

authors： Wu SC,Ke D,Su TL

更新日期：1998-01-01 00:00:00