Identifying patients with myasthenia for epidemiological research by linkage of automated registers.

Abstract:

BACKGROUND:We validated a new method of identifying patients with incident myasthenia in automated Danish registers for the purpose of conducting epidemiological studies of the disorder. METHODS:For residents of a Danish county (population 484,862) in 1993-2008, we identified any hospital contacts coded for myasthenia in a nationwide patient register and any prescriptions for pyridostigmine in the county prescription register. Results from an acetylcholine receptor antibody register were linked to the data. We verified the diagnosis by a review of medical records. RESULTS:Subjects identified in the Patient Register (n = 83) were comparable with individuals found in the Prescription Register (n = 89) with regard to age and gender, but were more often seropositive (83.1 vs. 74.2%). Seropositivity increased to 91.6% by restricting the data to individuals recorded in both Patient and Prescription Registers (n = 71). We found that for subjects identified in both Patient and Prescription Registers the positive predictive value of the register diagnosis was 92.9% (95% confidence interval, CI, 84.3-97.7), the false-positive rate was low (2.8%), and the sensitivity was acceptable (81.2%; 95% CI 71.2-88.8). CONCLUSIONS:Our data indicate that this novel approach of combining diagnosis register and prescription register information provides a feasible and valid method to trace incident myasthenia patients for population-based epidemiological studies.

journal_name

Neuroepidemiology

journal_title

Neuroepidemiology

authors

Pedersen EG,Hallas J,Hansen K,Jensen PE,Gaist D

doi

10.1159/000331481

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

120-8

issue

2

eissn

0251-5350

issn

1423-0208

pii

000331481

journal_volume

37

pub_type

杂志文章
  • Population-based epidemiological study of neurological diseases in Taiwan: I. Creutzfeldt-Jakob disease and multiple sclerosis.

    abstract:BACKGROUND:The purpose of the study is to investigate the epidemiology of Creutzfeldt-Jakob disease (CJD) and multiple sclerosis (MS) in Taiwan. METHODS:Cases of CJD and MS were identified from the National Health Insurance Research Database from January 2000 to December 2005. Age- and sex-specific incidences of these...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000229779

    authors: Lai CH,Tseng HF

    更新日期:2009-01-01 00:00:00

  • Stroke etiology among Haitians living in Miami.

    abstract::The black Caribbean population continues to grow in the US and little is known about stroke etiologies in that community. We examined stroke subtypes in 175 consecutive Haitian-born patients living in Miami, admitted for acute stroke. Ischemic stroke was diagnosed in 72%. Small vessel occlusion was the most frequent s...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000087449

    authors: Koch S,Pabon D,Rabinstein AA,Chirinos J,Romano JG,Forteza A

    更新日期:2005-01-01 00:00:00

  • Vascular disease among hospitalized multiple sclerosis patients.

    abstract:BACKGROUND:We examined the prevalence of cardiac and cerebrovascular disease among hospitalized patients with and without multiple sclerosis (MS). METHODS:This study used the Statewide Planning and Research Cooperate System data set of over 15 million hospitalizations in New York City from 1988 through 2002. We identi...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000128103

    authors: Allen NB,Lichtman JH,Cohen HW,Fang J,Brass LM,Alderman MH

    更新日期:2008-01-01 00:00:00

  • Stroke in South Asia: a systematic review of epidemiologic literature from 1980 to 2010.

    abstract:BACKGROUND:Globally 15 million people have an acute stroke every year and one third of them die secondary to stroke events. Most research on stroke prevention and treatment is done in developed countries, yet more than 85% of strokes occur in developing countries. In particular, stroke remains an underrecognized cause ...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章,评审

    doi:10.1159/000336230

    authors: Kulshreshtha A,Anderson LM,Goyal A,Keenan NL

    更新日期:2012-01-01 00:00:00

  • Assessment of cerebrovascular risk profiles in healthy persons: definition of research goals and the Austrian Stroke Prevention Study (ASPS).

    abstract::The advent of new laboratory methods and noninvasive imaging modalities has extended the diagnostic possibilities in normal individuals. This article elaborates the new options for the assessment of stroke risk offered by these techniques. In this context we present the Austrian Stroke Prevention Study, which is the f...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000110396

    authors: Schmidt R,Lechner H,Fazekas F,Niederkorn K,Reinhart B,Grieshofer P,Horner S,Offenbacher H,Koch M,Eber B

    更新日期:1994-01-01 00:00:00

  • Population-based surveillance of amyotrophic lateral sclerosis in New Jersey, 2009-2011.

    abstract:BACKGROUND:Limited epidemiological data exist about amyotrophic lateral sclerosis (ALS) in the United States (US). The Agency for Toxic Substances and Disease Registry maintains the National ALS Registry and funded state and metropolitan surveillance projects to obtain reliable, timely information about ALS in defined ...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000365850

    authors: Jordan H,Fagliano J,Rechtman L,Lefkowitz D,Kaye W

    更新日期:2014-01-01 00:00:00

  • Stroke in China (Sino-MONICA-Beijing study) 1984-1986.

    abstract::We present here the results of the Sino-MONICA-Beijing stroke study based on 700,000 Beijing residents in 1984-1986. To compare incidence rates for stroke with other communities and countries, we adopted the criteria of the WHO Collaborative Study of 17 centers which used the same definition and methodology as was use...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000110902

    authors: Chen D,Román GC,Wu GX,Wu ZS,Yao CH,Zhang M,Hirsch RP

    更新日期:1992-01-01 00:00:00

  • Prevalence of Common Types of Compression Neuropathies in Qena Governorate/Egypt: A Population-Based Survey.

    abstract:BACKGROUND:No epidemiological studies on the prevalence of compressive neuropathy have been undertaken in Arab countries. The aim of the study was to estimate the prevalence of the most common types of compressive neuropathies in Qena governorate/Egypt. METHODS:The study was part of a community-based survey carried ou...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000444641

    authors: Khedr EM,Fawi G,Allah Abbas MA,El-Fetoh NA,Zaki AF,Gamea A

    更新日期:2016-01-01 00:00:00

  • Ambient air quality and occurrence of multiple sclerosis relapse.

    abstract::Infectious viruses and bacteria can trigger multiple sclerosis (MS) exacerbations. Seasonally changing concentrations of ambient air pollutants are known to predispose to transmissible infections, to induce systemic immune responses and to enhance existing peripheral inflammation. Ambient air quality and monthly MS re...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000067108

    authors: Oikonen M,Laaksonen M,Laippala P,Oksaranta O,Lilius EM,Lindgren S,Rantio-Lehtimäki A,Anttinen A,Koski K,Erälinna JP

    更新日期:2003-01-01 00:00:00

  • The prevalence of hereditary spastic paraplegia and the occurrence of SPG4 mutations in Estonia.

    abstract:BACKGROUND:Hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneous disorder, with a variable reported prevalence ranging from 0.5 to 12 per 100,000. The aim of this retrospective study was to evaluate the prevalence of HSP and estimate the percentage of SPG4 mutations in the Estonian populatio...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000177033

    authors: Braschinsky M,Luus SM,Gross-Paju K,Haldre S

    更新日期:2009-01-01 00:00:00

  • Incidence and prevalence of motor neuron disease in two Danish counties.

    abstract::A total of 186 cases of motor neuron disease (MND) was identified in two Danish counties during the period 1974-1986. The average annual incidence rate was 1.4/100,000 population, and the male:female ratio of incidence rates was 1.5. Mean age at diagnosis was 64.3 +/- 10.0 years. The incidence rates increased signific...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000110177

    authors: Højer-Pedersen E,Christensen PB,Jensen NB

    更新日期:1989-01-01 00:00:00

  • A population-based prospective 24-month study of stroke: incidence and 30-day case-fatality rates of first-ever strokes in Croatia.

    abstract:BACKGROUND:In Central/Eastern European countries, cerebrovascular diseases are among the leading causes of mortality. We aimed to determine the incidence of first-ever stroke (FES) in the north-western part of Croatia. METHODS:A population-based prospective incidence study was conducted between July 1, 2007, and June ...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000336114

    authors: Pikija S,Cvetko D,Malojčić B,Trkanjec Z,Pavliček I,Lukić A,Kopjar A,Hajduk M,Andrović A,Bilić-Genter M,Trkulja V

    更新日期:2012-01-01 00:00:00

  • The level of awareness of stroke risk factors and symptoms in the Gulf Cooperation Council countries: Gulf Cooperation Council stroke awareness study.

    abstract:OBJECTIVE:To assess the knowledge of stroke in the general public in the Gulf Cooperation Council (GCC) countries. BACKGROUND:The Arabian Gulf is a rapidly developing part of the world with major changes in the lifestyle that can increase the risk of stroke. To design effective stroke treatment and prevention strategi...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000112856

    authors: Kamran S,Bener AB,Deleu D,Khoja W,Jumma M,Al Shubali A,Inshashi J,Sharouqi I,Al Khabouri J

    更新日期:2007-01-01 00:00:00

  • Hepatitis B vaccination and first central nervous system demyelinating event: a case-control study.

    abstract:OBJECTIVE:To investigate the relationship between hepatitis B (HB) vaccination and a first central nervous system (CNS) demyelinating event in adults. METHODS:In 1998, we conducted a multicentre, hospital-based case-control study which enrolled 402 cases of first CNS demyelinating event occurring between 1994 and 1995...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000059520

    authors: Touzé E,Fourrier A,Rue-Fenouche C,Rondé-Oustau V,Jeantaud I,Bégaud B,Alpérovitch A

    更新日期:2002-07-01 00:00:00

  • Secular trends in mortality rates from motor neuron disease in Kentucky 1964-1984.

    abstract::All death certificates with amyotrophic lateral sclerosis (ALS) or motor neuron disease (MND) as the primary or underlying cause occurring among Kentucky residents between 1964 and 1984 were manually reviewed. Geographic variability within Kentucky was evident for three intervals, 1964-1967, 1968-1978, and 1979-1984, ...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000110168

    authors: Stallones L,Kasarskis EJ,Stipanowich C,Snider G

    更新日期:1989-01-01 00:00:00

  • Clinical Expression of Multiple Sclerosis in Hispanic Whites of Primarily Caribbean Ancestry.

    abstract:OBJECTIVE:The clinical characteristics of multiple sclerosis (MS) are not well defined in Hispanic populations. We hypothesized that disease presentation in Hispanic white (HW) patients will be different from non-Hispanic white (NHW) patients given their ancestral background and reported lower disease prevalence. This ...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000431375

    authors: Hadjixenofontos A,Beecham AH,Manrique CP,Pericak-Vance MA,Tornes L,Ortega M,Rammohan KW,McCauley JL,Delgado SR

    更新日期:2015-01-01 00:00:00

  • The prevalence and severity of white matter lesions, their relationship with age, ethnicity, gender, and cardiovascular disease risk factors: the ARIC Study.

    abstract::White matter lesions (WMLs) detected by cerebral magnetic resonance imaging (MRI) are putatively a consequence of cerebral hypoperfusion or ischemia. We investigated the prevalence, severity and correlates of WMLs in a population-based sample of 1,920 African-American and European-American men and women aged 55-72 yea...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000368814

    authors: Liao D,Cooper L,Cai J,Toole J,Bryan N,Burke G,Shahar E,Nieto J,Mosley T,Heiss G

    更新日期:1997-01-01 00:00:00

  • Decline and rise of mortality from motor neuron disease in Spain, 1960-1989: demographic, environmental and competitive influences.

    abstract::Mortality rates from motor neuron disease (MND) in Spain were analysed for the years 1960-1989, a period in which 3,530 deaths were recorded from the disease and during which the crude annual mortality rate ranged between 0.35 and 0.95 deaths per 100,000 persons. Whilst the crude mortality rate fell by 54% during the ...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000109906

    authors: Neilson S,Robinson I,de Pedro-Cuesta J,Veiga-Cabo J

    更新日期:1996-01-01 00:00:00

  • Influence of Pre-Existing Mild Cognitive Impairment and Dementia on Post-Stroke Mortality. The Dijon Stroke Registry.

    abstract:OBJECTIVE:We assessed the association between pre-stroke cognitive status and 90-day case-fatality. METHODS:Patients with ischemic stroke (IS) or spontaneous intracerebral hemorrhage (ICH) were prospectively identified among residents of Dijon, France, between 2013 and 2015, using a population-based registry. Associat...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000497614

    authors: Graber M,Garnier L,Mohr S,Delpont B,Blanc-Labarre C,Vergely C,Giroud M,Béjot Y

    更新日期:2020-01-01 00:00:00

  • Prevalence, Mortality, and Cause of Death in Charcot-Marie-Tooth Disease in Korea: A Nationwide, Population-Based Study.

    abstract:BACKGROUND:Charcot-Marie-Tooth disease (CMT) is a group of clinically and genetically heterogeneous disorders that primarily affect the peripheral nervous system. Epidemiological studies of CMT have not yet been performed in Korea. OBJECTIVES:This study was performed to estimate the prevalence of CMT in Korea and the ...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000505815

    authors: Park HJ,Choi YC,Oh JW,Yi SW

    更新日期:2020-01-01 00:00:00

  • Case-control study of Meige's syndrome. Result of a pilot study.

    abstract::A pilot case-control study was conducted to identify possible risk factors for Meige's syndrome. Patients with Meige's syndrome and age- and sex-matched controls suffering from other neurological diseases were recruited from the Movement Disorders Clinic and Neurology Outpatient Department of the All India Insititute ...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000026265

    authors: Behari M,Sharma AK,Changkakoti S,Sharma N,Pandey RM

    更新日期:2000-09-01 00:00:00

  • Antecedent events in amyotrophic lateral sclerosis: do they influence clinical onset and progression?

    abstract::Risk factors for amyotrophic lateral sclerosis (ALS) such as country of residence, hard labour, intense athletic activities, heavy metal and pet exposure, skeletal trauma, surgical procedures, malignancies, and recurrent infectious disease were investigated in 77 patients and 80 controls, matching the cases for select...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000110782

    authors: Provinciali L,Giovagnoli AR

    更新日期:1990-01-01 00:00:00

  • Diabetes mellitus and cerebrovascular disease.

    abstract::In the past several years, a substantial amount of new information on the epidemiology and pathophysiology of diabetes and vascular disease has become available. Autopsy studies suggest that diabetic patients are susceptible to cerebral small-artery disease and lacunar infarction and may be at risk for large-artery at...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章,评审

    doi:10.1159/000026190

    authors: Lukovits TG,Mazzone TM,Gorelick TM

    更新日期:1999-01-01 00:00:00

  • The global epidemiology of hereditary ataxia and spastic paraplegia: a systematic review of prevalence studies.

    abstract:BACKGROUND:Hereditary cerebellar ataxias (HCA) and hereditary spastic paraplegias (HSP) are two groups of neurodegenerative disorders that usually present with progressive gait impairment, often leading to permanent disability. Advances in genetic research in the last decades have improved their diagnosis and brought n...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000358801

    authors: Ruano L,Melo C,Silva MC,Coutinho P

    更新日期:2014-01-01 00:00:00

  • Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease.

    abstract::The epsilon 4 allele of the apolipoprotein E (apoE) is associated with Alzheimer's disease (AD) and also with elevated serum total cholesterol and low-density lipoprotein levels. However, the interrelationships between apoE genotype, plasma cholesterol levels and AD risk have been studied very little. We examined the ...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000026149

    authors: Notkola IL,Sulkava R,Pekkanen J,Erkinjuntti T,Ehnholm C,Kivinen P,Tuomilehto J,Nissinen A

    更新日期:1998-01-01 00:00:00

  • Environmental Factors and the Risk of Brain Tumours in Young People: A Systematic Review.

    abstract:BACKGROUND:Brain tumours (BT) are one of the most frequent tumour types in young people, although little is known about their risk factors. OBJECTIVE:The objective of the current work was to review and summarize the scientific literature concerning exposure to environmental factors and BT risk in young people (<25 yea...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000500601

    authors: Zumel-Marne A,Castano-Vinyals G,Kundi M,Alguacil J,Cardis E

    更新日期:2019-01-01 00:00:00

  • Geographic and climatic factors and multiple sclerosis in some districts of Bulgaria.

    abstract::The multiple sclerosis (MS) prevalence rates in five districts of Bulgaria were compared with some geographic and climatic factors. In Bulgaria the latitude seems not to be a factor influencing the MS distribution. As to the climatic factors, a negative correlation was obtained between MS prevalence and mean annual su...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000110106

    authors: Kalafatova O

    更新日期:1987-01-01 00:00:00

  • A 15-Year Nationwide Epidemiological Analysis of Guillain-Barré Syndrome in Taiwan.

    abstract:BACKGROUND:Guillain-Barré syndrome (GBS) is a potentially life-threatening disease that typically occurs after a preceding infectious disease. An accurate estimation of GBS incidence would be useful for investigating the potential causal relationships between risk factors and GBS. Here we described the nationwide incid...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000430917

    authors: Huang WC,Lu CL,Chen SC

    更新日期:2015-01-01 00:00:00

  • Association between Hypertension and the Risk of Parkinson's Disease: A Meta-Analysis of Analytical Studies.

    abstract:BACKGROUND:The results of analytical studies show that the association between hypertension and the risk of Parkinson's disease (PD) remains controversial. METHOD:We searched studies related to the association between hypertension and the risk of PD. We pooled the ORs and risk ratios (RRs) with 95% confidence interval...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章,meta分析

    doi:10.1159/000496977

    authors: Chen J,Zhang C,Wu Y,Zhang D

    更新日期:2019-01-01 00:00:00

  • Patterns of mortality from hereditary ataxias in the United States, 1971 and 1973-1978.

    abstract::Mortality rates for deaths 'due to' and 'with' hereditary ataxias are presented for the first time. Age-adjusted mortality rates were higher for whites than for nonwhites of either sex, and for men in both racial groups. Age-specific mortality rates for whites showed a peak for 'hereditary spinal ataxia' in the 20-29 ...

    journal_title:Neuroepidemiology

    pub_type: 杂志文章

    doi:10.1159/000110182

    authors: Leone M,Chandra V,Schoenberg BS

    更新日期:1989-01-01 00:00:00