Abstract:
:A total of 186 cases of motor neuron disease (MND) was identified in two Danish counties during the period 1974-1986. The average annual incidence rate was 1.4/100,000 population, and the male:female ratio of incidence rates was 1.5. Mean age at diagnosis was 64.3 +/- 10.0 years. The incidence rates increased significantly with advancing age and reached a maximum at age 60-79 years, followed by a nonsignificant decrease. The average point prevalence was 3.1/100,000 population. Bulbar symptoms were part of the initial symptoms in 65% of cases, and patients with bulbar onset were older than patients with spinal onset. Age- and sex-specific incidence rates indicated a marked male preponderance amongst the youngest patients, in contrast to a female preponderance in patients above 60 years with bulbar onset of MND. Familial MND accounted for 2.7% of cases.
journal_name
Neuroepidemiologyjournal_title
Neuroepidemiologyauthors
Højer-Pedersen E,Christensen PB,Jensen NBdoi
10.1159/000110177subject
Has Abstractpub_date
1989-01-01 00:00:00pages
151-9issue
3eissn
0251-5350issn
1423-0208journal_volume
8pub_type
杂志文章abstract::Cerebrovascular diseases (CVDs) constitute the most frequent cause of death in Spain. In order to identify the geographical pattern of CVD mortality, age- and sex-specific as well as age-adjusted mortality rates (ICD-8,9 rubrics 430-438) were calculated for the period 1975-1986 for each province in the country. Maps w...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000109792
更新日期:1995-01-01 00:00:00
abstract::The epsilon 4 allele of the apolipoprotein E (apoE) is associated with Alzheimer's disease (AD) and also with elevated serum total cholesterol and low-density lipoprotein levels. However, the interrelationships between apoE genotype, plasma cholesterol levels and AD risk have been studied very little. We examined the ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000026149
更新日期:1998-01-01 00:00:00
abstract::The multiple sclerosis (MS) prevalence rates in five districts of Bulgaria were compared with some geographic and climatic factors. In Bulgaria the latitude seems not to be a factor influencing the MS distribution. As to the climatic factors, a negative correlation was obtained between MS prevalence and mean annual su...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110106
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Smoking increases the risk of multiple sclerosis (MS) and possibly disease progression. The reliability of self-reported smoking status is unknown in MS. We assessed the reliability of self-reported smoking status among participants in the North American Research Committee on Multiple Sclerosis (NARCOMS) Reg...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000170910
更新日期:2009-01-01 00:00:00
abstract::A comparison of epidemiological and clinical features of trigeminal neuralgia (TN) and glossopharyngeal neuralgia (GN) in Rochester, Minn., reveals several differences. The overall age- and sex-adjusted annual incidence rates were significantly higher for TN than for GN (4.7 vs. 0.8 per 100,000 population). The TN:GN ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110284
更新日期:1991-01-01 00:00:00
abstract::In the past several years, a substantial amount of new information on the epidemiology and pathophysiology of diabetes and vascular disease has become available. Autopsy studies suggest that diabetic patients are susceptible to cerebral small-artery disease and lacunar infarction and may be at risk for large-artery at...
journal_title:Neuroepidemiology
pub_type: 杂志文章,评审
doi:10.1159/000026190
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:The goal of this study was to assess the validity of a screening question for head tremor in essential tremor (ET). There are no published data on this topic, and the knowledge will guide future epidemiological investigations of this disorder. METHODS:These analyses utilized four distinct patient samples: a...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000365991
更新日期:2014-01-01 00:00:00
abstract::The incidence rate for primary intracranial neoplasms in the province of Trento (Italy) is 8.5/100,000/year, but the figures in the eleven administrative units ('comprensori') are different. The increased rates in C6 Val di Non and C10 Vallagarina are mainly due to the number of malignant tumors in the 45- to 64-year-...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110825
更新日期:1986-01-01 00:00:00
abstract::White matter lesions (WML) on MRI of the brain are common in both demented and nondemented older persons. They may be due to ischemic events and are associated with cognitive and physical impairments. It is not known whether the prevalence of these WML in the general population differs across European countries in a p...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000089233
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Parkinson's disease (PD) is the most common neurodegenerative disease after Alzheimer's dementia. Whereas the exact etiology of PD remains unknown, risk of developing PD seems to be related to a combination of genetic and environmental factors. This also includes abnormal exposure to trace elements of nutrit...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000502357
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To assess the knowledge of stroke in the general public in the Gulf Cooperation Council (GCC) countries. BACKGROUND:The Arabian Gulf is a rapidly developing part of the world with major changes in the lifestyle that can increase the risk of stroke. To design effective stroke treatment and prevention strategi...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000112856
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The effects of oophorectomy on brain aging remain uncertain. METHODS:We conducted a cohort study with long-term follow-up of women in Olmsted County, Minn., USA, who underwent either unilateral or bilateral oophorectomy before the onset of menopause from 1950 through 1987. Each member of the oophorectomy co...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000211951
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneous disorder, with a variable reported prevalence ranging from 0.5 to 12 per 100,000. The aim of this retrospective study was to evaluate the prevalence of HSP and estimate the percentage of SPG4 mutations in the Estonian populatio...
journal_title:Neuroepidemiology
pub_type: 杂志文章,多中心研究
doi:10.1159/000177033
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND/AIMS:Neurosarcoidosis is a rare condition with serious health consequences. However, little is known about clinical characteristics and outcome of neurosarcoidosis in the community setting. METHODS:Patients with neurosarcoidosis were identified from a previously described cohort of patients with incident sa...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000477300
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Hereditary cerebellar ataxias (HCA) and hereditary spastic paraplegias (HSP) are two groups of neurodegenerative disorders that usually present with progressive gait impairment, often leading to permanent disability. Advances in genetic research in the last decades have improved their diagnosis and brought n...
journal_title:Neuroepidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000358801
更新日期:2014-01-01 00:00:00
abstract::We tested the feasibility of a fully automated brain MRI voxel count technique--automated labeling pathway (ALP)--in a sample of 15 demented and 13 cognitively normal women (age 75-85 years) participating to the Cardiovascular Health Study (CHS). We hypothesized that ALP would replicate well-established findings of th...
journal_title:Neuroepidemiology
pub_type: 临床试验,杂志文章
doi:10.1159/000085140
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Brain tumours (BT) are one of the most frequent tumour types in young people, although little is known about their risk factors. OBJECTIVE:The objective of the current work was to review and summarize the scientific literature concerning exposure to environmental factors and BT risk in young people (<25 yea...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000500601
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Anthropometric indexes are powerful indicators of the environment and the plasticity of the human body. This study aimed at exploring the anthropometric indexes that are associated with late-life cognition impairment among the elderly Chinese in the Shanghai Aging Study. METHODS:The height, weight, and sitt...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000439569
更新日期:2015-01-01 00:00:00
abstract::The incidence rates of primary nervous system neoplasms in 5 districts (large administrative units) of Western Poland with a relatively homogeneous health care system but some contrasts in economic activity, as well as in 224 communes (smallest administrative units) located within these 5 districts, with a total popul...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110212
更新日期:1985-01-01 00:00:00
abstract::The Canadian Study of Health and Aging (CSHA) provided a population-based estimate of the prevalence of dementia of 8% for those aged 65 and older. Other studies have produced both higher and lower prevalence estimates. Factors that may contribute to these differences include: the use of or the reliance on neuropsycho...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000026247
更新日期:2000-05-01 00:00:00
abstract::This study is based on 166 patients with definite multiple sclerosis (MS) residing in different Italian regions and on 332 parents and 326 siblings. Seven patients had a first-degree relative with a definite diagnosis. The comparison with a population age-matched for specific frequency of MS showed an increase of the ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110198
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Exercise is hypothesized to improve cognition, physical performance, functional ability and quality of life, but evidence is scarce. Previous studies were of short duration, often underpowered and involving home-based light exercise programs in patients with undefined dementia. The aim of the ADEX ('Preservi...
journal_title:Neuroepidemiology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000354632
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:White matter hyperintensities (WMHs) are a risk factor for stroke. Their etiology is considered to be cerebral microvascular abnormality. However, the association between WMHs and arteriosclerosis is not yet clear. The aim of this hospital-based cohort study was to identify the arteriosclerotic characteristi...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000328260
更新日期:2011-01-01 00:00:00
abstract::According to studies done before 1980, the multiple sclerosis (MS) prevalence rate in Italy ranged from 7.2 to 27.1 cases per 100,000 inhabitants. More recent work has consistently put the MS prevalence rate to over 30 cases per 100,000 inhabitants. If these recent data are confirmed in the future, Italy can no longer...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110249
更新日期:1991-01-01 00:00:00
abstract::Seizures precipitated by the stimulus of hot water known as 'hot water epilepsy' (HWE) have been commonly reported from South India. The present report outlines certain descriptive epidemiological aspects of 78 cases from two rural satellite clinics of National Institute of Mental Health and Neuro Sciences (NIMHANS), ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110929
更新日期:1992-01-01 00:00:00
abstract::Between 1992 and 2040, the United States nonwhite elderly population is expected to grow from 3.3 to 14.1 million. In order to assess the implications of this increase on the mortality from neurodegenerative diseases in the United States, we used Census Bureau population estimates to formulate projections of the annua...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110377
更新日期:1994-01-01 00:00:00
abstract:INTRODUCTION:Amyotrophic lateral sclerosis (ALS) is a rare, rapidly progressive neurodegenerative disease. Despite wide variability in the incidence and prevalence of ALS, there is evidence of positive temporal trends and an increase in incidence with age. The aim of this study was to conduct a detailed epidemiological...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000477126
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The results of analytical studies show that the association between hypertension and the risk of Parkinson's disease (PD) remains controversial. METHOD:We searched studies related to the association between hypertension and the risk of PD. We pooled the ORs and risk ratios (RRs) with 95% confidence interval...
journal_title:Neuroepidemiology
pub_type: 杂志文章,meta分析
doi:10.1159/000496977
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The risk of dementia increases by 15-28% in patients with type 2 diabetes mellitus (DM). However, studies on dementia risk in type 1 DM have been neither comprehensive nor conclusive. METHODS:We carried out a cohort study involving 1,077 patients registered to have type 1 DM from 1998 to 2009 and 32,310 mat...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000486719
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIMS:Brain tumors are the second most common pediatric malignancy. The literature suggests that one of the most common subtypes of malignant childhood brain tumor, medulloblastoma, has some seasonal variation in incidence by month of birth. METHODS:Data from cases in the Central Brain Tumor Registry of the ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000109502
更新日期:2007-01-01 00:00:00