Abstract:
BACKGROUND:Parkinson's disease (PD) is the most common neurodegenerative disease after Alzheimer's dementia. Whereas the exact etiology of PD remains unknown, risk of developing PD seems to be related to a combination of genetic and environmental factors. This also includes abnormal exposure to trace elements of nutritional and toxicological interest. OBJECTIVES:In this systematic review and meta-analysis, we summarized the results of case-control studies comparing levels of selenium, copper, iron, and zinc in PD patients and controls in either blood (whole blood, serum/plasma) or cerebrospinal fluid (CSF). METHODS:We performed a systematic PubMed search selecting studies reporting trace element levels in different specimens of patients and controls. We performed a meta-analysis using a random-effect model to compute the weighted mean differences (WMD) and corresponding 95% CI of selenium, copper, iron, and zinc levels in the blood or CSF of patients and their matched controls. RESULTS:We retrieved 56 papers reporting data for selenium (cases/controls: 588/721), copper (2,190/2,522), iron (2,956/3,469), and zinc (1,798/1,913) contents in CSF and blood. Cases showed considerably higher levels of selenium in CSF compared with controls (+51.6%; WMD 5.49; 95% CI 2.82 to 8.15), while levels in serum were similar (-0.2%; WMD -0.22; 95% CI -8.05 to 7.62). For copper, cases showed slightly higher levels in CSF and slightly lower concentrations in serum (+4.5%; WMD 1.87; 95% CI -3.59 to 7.33, and -4.5%; WMD -42.79; 95% CI -134.35 to 48.76, respectively). A slight increase was also found for CSF iron -levels (+9.5%; WMD 9.92; 1.23 to 18.61), while levels were -decreased in serum/plasma (-5.7%; WMD -58.19; 95% CI -106.49 to -9.89) and whole blood (-10.8%; WMD -95.69; 95% CI -157.73 to -33.65). Conversely, for zinc cases exhibited lower levels both in CSF (-10.8%; WMD -7.34; 95% CI -14.82 to 0.14) and serum/plasma (-7.5%; WMD -79.93; 95% CI -143.80 to -16.06). A longer duration of the disease tends to be associated with overall lower trace element levels in either CSF or blood. CONCLUSIONS:Due to the study findings and the greater relevance of the CSF compartment compared with the circulating peripheral ones, this meta-analysis suggests that overexposure in the central nervous system to selenium, and possibly to copper and iron, may be a risk factor of the disease, while zinc might have a protective -effect.
journal_name
Neuroepidemiologyjournal_title
Neuroepidemiologyauthors
Adani G,Filippini T,Michalke B,Vinceti Mdoi
10.1159/000502357subject
Has Abstractpub_date
2020-01-01 00:00:00pages
1-23issue
1eissn
0251-5350issn
1423-0208pii
000502357journal_volume
54pub_type
杂志文章abstract::This paper presents the current status and use of virtual reality (VR) for children with attention deficit hyperactivity disorder (ADHD), autism and cerebral palsy. This literature review explores how VR systems have been used as treatment tools to address the primary impairments of these disorders. Three major classe...
journal_title:Neuroepidemiology
pub_type: 杂志文章,评审
doi:10.1159/000320847
更新日期:2011-01-01 00:00:00
abstract::This study is a time series analysis of the utilization of L-dopa derivatives (LDD) and bromocriptine by parkinsonism (PA) patients and of the age-specific PA prevalences estimated by using a previously reported model. The model combines information on LDD sales, infant mortality rates (IMR) and demographic data for S...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110228
更新日期:1985-01-01 00:00:00
abstract::Stroke and ischemic heart disease (IHD) mortality rates were analyzed in Brazilian subjects older than 30 years of age from 1979 to 1996. Population estimates were based on census surveys. Mortality data were obtained from the Ministry of Health. For stroke, the age-adjusted death rate (ADR) dropped from 200 to 164 an...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000069893
更新日期:2003-05-01 00:00:00
abstract::This paper describes a proposed study to investigate the incidence of dementia in a population of over 75 year olds in Melton Mowbray, Leicestershire, England. The study population (n = 438) underwent a detailed psychiatric assessment using the Cambridge Examination for Mental Disorders of the Elderly (CAMDEX) as the ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110980
更新日期:1992-01-01 00:00:00
abstract::We performed a community-based study on a cohort of 221 stroke patients followed for 3 years. In this paper, we tried to answer the following questions: Is the risk of dying increased throughout the first 3 years after stroke? What are the causes of death after the 1st month? What factors at stroke onset are independe...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000069410
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:The risk of dementia increases by 15-28% in patients with type 2 diabetes mellitus (DM). However, studies on dementia risk in type 1 DM have been neither comprehensive nor conclusive. METHODS:We carried out a cohort study involving 1,077 patients registered to have type 1 DM from 1998 to 2009 and 32,310 mat...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000486719
更新日期:2018-01-01 00:00:00
abstract::Trends of multiple sclerosis mortality in Spain from 1951 to 1997 are examined. Age-adjusted mortality strongly decreased from 3.08 per 100,000 women in 1951-1967 to 0.59 in 1968-1980 (similar figures were obtained for men). This decrease seems to be due to an artifact produced by changes in codification of causes of ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000083000
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Mild cognitive impairment (MCI) has been suggested as a term for a boundary area between normal aging and dementia. This study was designed to determine the prevalence of MCI in the elderly in the Hebei province, China, and explore its related factors. METHODS:Participants included 2,601 community-dwelling ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000357374
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND/AIMS:Cognitive decline is a defining feature of dementia. We sought to determine if a single baseline cognitive test score or change in test score over time is more strongly associated with risk of dementia hospitalization. We also sought to compare short- and long-term dementia risk. METHODS:Prospective co...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000342308
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND/AIMS:Neurosarcoidosis is a rare condition with serious health consequences. However, little is known about clinical characteristics and outcome of neurosarcoidosis in the community setting. METHODS:Patients with neurosarcoidosis were identified from a previously described cohort of patients with incident sa...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000477300
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Brain tumours (BT) are one of the most frequent tumour types in young people, although little is known about their risk factors. OBJECTIVE:The objective of the current work was to review and summarize the scientific literature concerning exposure to environmental factors and BT risk in young people (<25 yea...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000500601
更新日期:2019-01-01 00:00:00
abstract:AIM:We examined trends in incidence of stroke of any nature (ischemic and/or hemorrhagic) in subjects with a hospital diagnosis of nonvalvular atrial fibrillation or flutter in Denmark from 1980 to 2002 by sex, age and conditions of comorbidity. METHODS:We identified all individuals, aged 40-89 years, with an incident...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000092795
更新日期:2006-01-01 00:00:00
abstract::Recent reports of declining trends in mortality rates from cerebrovascular disease are based on underlying cause of death as stated on the death certificate, and may contain inaccuracies because death certificates are often completed without reference to all information in medical records, and because of changes in co...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110160
更新日期:1989-01-01 00:00:00
abstract::We present here the results of the Sino-MONICA-Beijing stroke study based on 700,000 Beijing residents in 1984-1986. To compare incidence rates for stroke with other communities and countries, we adopted the criteria of the WHO Collaborative Study of 17 centers which used the same definition and methodology as was use...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110902
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND AND METHODS:The high prevalence of epilepsy detected in rural Tanzania by Dr. Jilek-Aall since 1960, was verified by the World Health Organization (WHO) survey on neurological and seizure disorders. Neurologists and psychiatrists further interviewed both patients and controls using standard methods. The pres...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000054797
更新日期:2001-10-01 00:00:00
abstract::Homocysteine is a metabolite of methionine that may be remethylated by enzymes requiring folate and cobalamin (vitamin B12) to again form methionine or catabolized by the pyridoxine (vitamin B6) dependent enzyme, cystathionine beta synthase (CBS) to form cysteine (fig. 1) [1]. Homocysteine exists as a combination of v...
journal_title:Neuroepidemiology
pub_type: 杂志文章,评审
doi:10.1159/000026169
更新日期:1998-01-01 00:00:00
abstract::The purpose of our study was to determine the incidence of stroke, case-fatality rate and disability at 1 year in the Valley of Aosta (Italy) in the years 2004 and 2005. All suspected strokes occurring between January 1, 2004, and December 31, 2005, in the resident population of the Valley of Aosta were identified acc...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000195688
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND AND AIMS:The impact of statin on dementia risk reduction has been a subject of debate over the last decade, but the evidence remains inconclusive. Therefore, we performed a meta-analysis of relevant observational studies to quantify the magnitude of the association between statin therapy and the risk of deme...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000503105
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Familial aggregation has been shown for Alzheimer's disease (AD) and Parkinson's disease (PD) separately, and it has been hypothesized that these diseases also coaggregate in families. METHODS:The authors investigated familial coaggregation of AD and PD by conducting a systematic review and meta-analysis. P...
journal_title:Neuroepidemiology
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000355452
更新日期:2014-01-01 00:00:00
abstract::We tested the feasibility of a fully automated brain MRI voxel count technique--automated labeling pathway (ALP)--in a sample of 15 demented and 13 cognitively normal women (age 75-85 years) participating to the Cardiovascular Health Study (CHS). We hypothesized that ALP would replicate well-established findings of th...
journal_title:Neuroepidemiology
pub_type: 临床试验,杂志文章
doi:10.1159/000085140
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:White matter hyperintensities (WMHs) are a risk factor for stroke. Their etiology is considered to be cerebral microvascular abnormality. However, the association between WMHs and arteriosclerosis is not yet clear. The aim of this hospital-based cohort study was to identify the arteriosclerotic characteristi...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000328260
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Repetitive head trauma is an identified risk factor for Alzheimer's disease (AD). The violence in wife assault is repetitive and targets the head. This association provides a rationale for studying the relationship between spousal abuse and AD. DESIGN:To preliminarily evaluate the possibility of an increase...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000093894
更新日期:2006-01-01 00:00:00
abstract::Little is known regarding the pathogenetic factors for Alzheimer's disease (AD). We studied 63 AD patients in order to evaluate if there were clinical subtypes of AD and whether prior illnesses and life-styles were involved in the development of the disease. In our patients selected for onset of symptoms before age 65...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110750
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:The clinical characteristics of multiple sclerosis (MS) are not well defined in Hispanic populations. We hypothesized that disease presentation in Hispanic white (HW) patients will be different from non-Hispanic white (NHW) patients given their ancestral background and reported lower disease prevalence. This ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000431375
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Providing a valid and sensitive measure of different domains of cognitive performance in epidemiologic studies of early old-age populations presents a methodological challenge, given the broad range of variability in cognitive functioning in this age group. OBJECTIVES:(1) To provide data on the distribution...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000328262
更新日期:2011-01-01 00:00:00
abstract::Transcranial Doppler ultrasonography allows the non-invasive assessment of cerebral haemodynamics. Data on the frequency distribution of these parameters in the oldest old are scarce, which makes a distinction between physiological and pathophysiological ageing difficult. We studied the relation between cerebral haemo...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000078503
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Our objective was to determine the cerebrovascular prevalence in a town in the Brazilian Amazon basin and compare the ribeirinhos (riparians) to the urban population in the same municipality. METHODS:From May to October 2011, 6,216 residents over 35 years of age in the town of Coari were interviewed using a...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000362210
更新日期:2014-01-01 00:00:00
abstract::We studied the prevalence of Parkinson's disease (PD) in Gypsies and Caucasians in Bulgaria. Cases were ascertained by examination in a clinic, a screening questionnaire and a door-to-door survey in a region of Sofia, Bulgaria. The prevalence of PD in the Gypsies was found to be 16/100,000 based on 1 case compared to ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000026257
更新日期:2000-07-01 00:00:00
abstract::Cerebrovascular diseases (CVDs) constitute the most frequent cause of death in Spain. In order to identify the geographical pattern of CVD mortality, age- and sex-specific as well as age-adjusted mortality rates (ICD-8,9 rubrics 430-438) were calculated for the period 1975-1986 for each province in the country. Maps w...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000109792
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:The purpose of the study is to investigate the epidemiology of Creutzfeldt-Jakob disease (CJD) and multiple sclerosis (MS) in Taiwan. METHODS:Cases of CJD and MS were identified from the National Health Insurance Research Database from January 2000 to December 2005. Age- and sex-specific incidences of these...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000229779
更新日期:2009-01-01 00:00:00