Abstract:
BACKGROUND:The effects of oophorectomy on brain aging remain uncertain. METHODS:We conducted a cohort study with long-term follow-up of women in Olmsted County, Minn., USA, who underwent either unilateral or bilateral oophorectomy before the onset of menopause from 1950 through 1987. Each member of the oophorectomy cohort was matched by age to a referent woman from the same population who had not undergone any oophorectomy. We studied underlying and contributory causes of death in 1,274 women with unilateral oophorectomy, 1,091 women with bilateral oophorectomy, and 2,383 referent women. RESULTS:Mortality for neurological or mental diseases was increased in women who underwent bilateral oophorectomy before age 45 years compared with referent women (hazard ratio = 5.24; 95% confidence interval = 2.02-13.6; p < 0.001). Within this age stratum, mortality was similar in women who were or were not treated with estrogen from the time of oophorectomy through age 45 years, and in women who had bilateral oophorectomy for prophylaxis or for treatment of a benign ovarian condition. Mortality was also increased in women who underwent unilateral oophorectomy before age 45 years without concurrent hysterectomy. CONCLUSIONS:Bilateral oophorectomy performed before age 45 years is associated with increased mortality for neurological or mental diseases.
journal_name
Neuroepidemiologyjournal_title
Neuroepidemiologyauthors
Rivera CM,Grossardt BR,Rhodes DJ,Rocca WAdoi
10.1159/000211951subject
Has Abstractpub_date
2009-01-01 00:00:00pages
32-40issue
1eissn
0251-5350issn
1423-0208pii
000211951journal_volume
33pub_type
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