Different aetiology of familial low-grade and high-grade glioma? A nationwide cohort study of familial glioma.

Abstract:

:An increased risk for first-degree relatives (FDR) of glioma patients has previously been observed. The novel objective of this study was to investigate differences in familial risk among FDR of low-grade glioma (LGG) and high-grade glioma (HGG) cases, respectively. Two cohorts were constructed, one from 15,321 FDR of LGG cases and the other from 26,635 FDR of HGG cases calculating standardised incidence ratios (SIR). The risk for LGG among FDR of LGG cases was significantly increased, SIR 3.65 (95% CI 2.31-5.47). The risk was even higher in the cohort of siblings, SIR 7.00 (95% CI 3.35-12.87), and especially in the younger siblings (<40 years), SIR 9.01 (95% CI 4.31-16.57). When calculating the risk for HGG in the LGG cohort and the risk for HGG in the HGG cohort, there was a generally twofold increased risk, but no trends of increased risk in relatives of younger probands. Two different methods calculating familial risk displayed similar results. LGG families apparently have features manifesting a distinct pedigree pattern with sibpairs affected at a young age. These families could provide new insights into the aetiology of glioma.

journal_name

Neuroepidemiology

journal_title

Neuroepidemiology

authors

Malmer B,Henriksson R,Grönberg H

doi

10.1159/000065528

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

279-86

issue

6

eissn

0251-5350

issn

1423-0208

pii

65528

journal_volume

21

pub_type

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