Patterns of mortality from hereditary ataxias in the United States, 1971 and 1973-1978.


:Mortality rates for deaths 'due to' and 'with' hereditary ataxias are presented for the first time. Age-adjusted mortality rates were higher for whites than for nonwhites of either sex, and for men in both racial groups. Age-specific mortality rates for whites showed a peak for 'hereditary spinal ataxia' in the 20-29 age group. For the other types of ataxias they were low until age 40 and increased thereafter. Heart diseases were a frequent cause of death in people dying 'with' hereditary ataxias. The median survival (from birth) for hereditary spinal ataxia in whites was 35 years.






Leone M,Chandra V,Schoenberg BS




Has Abstract


1989-01-01 00:00:00












  • The relation of cigarette smoking to incident Alzheimer's disease in a biracial urban community population.

    abstract::The relationship between smoking status and incident Alzheimer's disease (AD) was investigated in a random stratified sample of a biracial community in Chicago. Analyses are based on 1,064 persons (of 1,134 evaluated) who had data on smoking status, disease incidence, and key covariates such as apolipoprotein allele s...


    pub_type: 杂志文章


    authors: Aggarwal NT,Bienias JL,Bennett DA,Wilson RS,Morris MC,Schneider JA,Shah RC,Evans DA

    更新日期:2006-01-01 00:00:00

  • Decline and rise of mortality from motor neuron disease in Spain, 1960-1989: demographic, environmental and competitive influences.

    abstract::Mortality rates from motor neuron disease (MND) in Spain were analysed for the years 1960-1989, a period in which 3,530 deaths were recorded from the disease and during which the crude annual mortality rate ranged between 0.35 and 0.95 deaths per 100,000 persons. Whilst the crude mortality rate fell by 54% during the ...


    pub_type: 杂志文章


    authors: Neilson S,Robinson I,de Pedro-Cuesta J,Veiga-Cabo J

    更新日期:1996-01-01 00:00:00

  • Stroke in the rain forest: prevalence in a ribeirinha community and an urban population in the Brazilian Amazon.

    abstract:BACKGROUND:Our objective was to determine the cerebrovascular prevalence in a town in the Brazilian Amazon basin and compare the ribeirinhos (riparians) to the urban population in the same municipality. METHODS:From May to October 2011, 6,216 residents over 35 years of age in the town of Coari were interviewed using a...


    pub_type: 杂志文章


    authors: Fernandes TG,Benseñor IM,Goulart AC,Tavares BM,Alencar AP,Santos IS,Lotufo PA

    更新日期:2014-01-01 00:00:00

  • Epidemiology and clinical features of idiopathic trigeminal neuralgia and glossopharyngeal neuralgia: similarities and differences, Rochester, Minnesota, 1945-1984.

    abstract::A comparison of epidemiological and clinical features of trigeminal neuralgia (TN) and glossopharyngeal neuralgia (GN) in Rochester, Minn., reveals several differences. The overall age- and sex-adjusted annual incidence rates were significantly higher for TN than for GN (4.7 vs. 0.8 per 100,000 population). The TN:GN ...


    pub_type: 杂志文章


    authors: Katusic S,Williams DB,Beard CM,Bergstralh EJ,Kurland LT

    更新日期:1991-01-01 00:00:00

  • Influence of Pre-Existing Mild Cognitive Impairment and Dementia on Post-Stroke Mortality. The Dijon Stroke Registry.

    abstract:OBJECTIVE:We assessed the association between pre-stroke cognitive status and 90-day case-fatality. METHODS:Patients with ischemic stroke (IS) or spontaneous intracerebral hemorrhage (ICH) were prospectively identified among residents of Dijon, France, between 2013 and 2015, using a population-based registry. Associat...


    pub_type: 杂志文章


    authors: Graber M,Garnier L,Mohr S,Delpont B,Blanc-Labarre C,Vergely C,Giroud M,Béjot Y

    更新日期:2020-01-01 00:00:00

  • Assessing the clinical importance of statistically significant improvement in anti-dementia drug trials.

    abstract::A strategy for assessing the clinical importance of statistically significant treatment benefits in recent dementia drug trials is proposed. Traditional criteria for the assessment of valid inferences are helpful: the more likely the treatment effects are valid, the greater the chance that they will be clinically impo...


    pub_type: 杂志文章


    authors: Rockwood K,MacKnight C

    更新日期:2001-05-01 00:00:00

  • The prevalence of cognitive impairment among nursing home residents in Taipei, Taiwan.

    abstract::A random sample of nursing home residents over 65 years of age were interviewed. Two hundred ninety-two participants received the Short Portable Mental Status Questionnaire. Two hundred eleven were unable to answer the questionnaire, but their caregivers provided information about their daily activities and performanc...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wu SC,Ke D,Su TL

    更新日期:1998-01-01 00:00:00

  • The prevalence and severity of white matter lesions, their relationship with age, ethnicity, gender, and cardiovascular disease risk factors: the ARIC Study.

    abstract::White matter lesions (WMLs) detected by cerebral magnetic resonance imaging (MRI) are putatively a consequence of cerebral hypoperfusion or ischemia. We investigated the prevalence, severity and correlates of WMLs in a population-based sample of 1,920 African-American and European-American men and women aged 55-72 yea...


    pub_type: 杂志文章


    authors: Liao D,Cooper L,Cai J,Toole J,Bryan N,Burke G,Shahar E,Nieto J,Mosley T,Heiss G

    更新日期:1997-01-01 00:00:00

  • Preserving cognition, quality of life, physical health and functional ability in Alzheimer's disease: the effect of physical exercise (ADEX trial): rationale and design.

    abstract:BACKGROUND:Exercise is hypothesized to improve cognition, physical performance, functional ability and quality of life, but evidence is scarce. Previous studies were of short duration, often underpowered and involving home-based light exercise programs in patients with undefined dementia. The aim of the ADEX ('Preservi...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Hoffmann K,Frederiksen KS,Sobol NA,Beyer N,Vogel A,Simonsen AH,Johannsen P,Lolk A,Terkelsen O,Cotman CW,Hasselbalch SG,Waldemar G

    更新日期:2013-01-01 00:00:00

  • The role of systematic reviews and meta-analyses of incidence and prevalence studies in neuroepidemiology.

    abstract:BACKGROUND:Systematic reviews and meta-analyses on the incidence and prevalence of neurological conditions are important methods of quantifying the burden and risk of disease. METHODS:The rigorous methodology required in order to minimize publication bias, account for study heterogeneity, and variation in study qualit...


    pub_type: 杂志文章


    authors: Fiest KM,Pringsheim T,Patten SB,Svenson LW,Jetté N

    更新日期:2014-01-01 00:00:00

  • The confounding of race and geography: how much of the excess stroke mortality among African Americans is explained by geography?

    abstract:INTRODUCTION:The excess stroke mortality among African Americans and Southerners is well known. Because a higher proportion of the population living in the 'Stroke Belt' is African American, then a portion of the estimated excess risk of stroke death traditionally associated with African-American race may be attributab...


    pub_type: 杂志文章


    authors: Yang D,Howard G,Coffey CS,Roseman J

    更新日期:2004-05-01 00:00:00

  • The prevalence of hereditary spastic paraplegia and the occurrence of SPG4 mutations in Estonia.

    abstract:BACKGROUND:Hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneous disorder, with a variable reported prevalence ranging from 0.5 to 12 per 100,000. The aim of this retrospective study was to evaluate the prevalence of HSP and estimate the percentage of SPG4 mutations in the Estonian populatio...


    pub_type: 杂志文章,多中心研究


    authors: Braschinsky M,Luus SM,Gross-Paju K,Haldre S

    更新日期:2009-01-01 00:00:00

  • Validity and reliability of the 'Ten Questions' questionnaire for detecting moderate to severe neurological impairment in children aged 6-9 years in rural Kenya.

    abstract:BACKGROUND:The 'Ten Questions' Questionnaire (TQQ) is used to detect severe neurological impairment in children living in resource-poor countries. Its usefulness has been established in Asia and the Caribbean, but there are a few published studies from Africa. We evaluated the TQQ as part of a larger study of neurologi...


    pub_type: 杂志文章


    authors: Mung'ala-Odera V,Meehan R,Njuguna P,Mturi N,Alcock K,Carter JA,Newton CR

    更新日期:2004-01-01 00:00:00

  • Spatial distribution of stroke mortality in Spain, 1975-1986.

    abstract::Cerebrovascular diseases (CVDs) constitute the most frequent cause of death in Spain. In order to identify the geographical pattern of CVD mortality, age- and sex-specific as well as age-adjusted mortality rates (ICD-8,9 rubrics 430-438) were calculated for the period 1975-1986 for each province in the country. Maps w...


    pub_type: 杂志文章


    authors: Barrado-Lanzarote MJ,Almazan-Isla J,Medrano-Albero MJ,de Pedro-Cuesta J

    更新日期:1995-01-01 00:00:00

  • Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease.

    abstract::The epsilon 4 allele of the apolipoprotein E (apoE) is associated with Alzheimer's disease (AD) and also with elevated serum total cholesterol and low-density lipoprotein levels. However, the interrelationships between apoE genotype, plasma cholesterol levels and AD risk have been studied very little. We examined the ...


    pub_type: 杂志文章


    authors: Notkola IL,Sulkava R,Pekkanen J,Erkinjuntti T,Ehnholm C,Kivinen P,Tuomilehto J,Nissinen A

    更新日期:1998-01-01 00:00:00

  • Higher Education Is Associated with a Lower Risk of Dementia after a Stroke or TIA. The Rotterdam Study.

    abstract:BACKGROUND:Higher education is associated with a lower risk of dementia, possibly because of a higher tolerance to subclinical neurodegenerative pathology. Whether higher education also protects against dementia after clinical stroke or transient ischemic attack (TIA) remains unknown. METHODS:Within the population-bas...


    pub_type: 杂志文章


    authors: Mirza SS,Portegies ML,Wolters FJ,Hofman A,Koudstaal PJ,Tiemeier H,Ikram MA

    更新日期:2016-01-01 00:00:00

  • The management approaches to dyskinesia vary from country to country.

    abstract::Many Parkinson's disease (PD) patients treated with levodopa develop motor fluctuations and/or dyskinesia. This large, retrospective study was conducted to compare the prevalence and treatment of dyskinesia in PD patients in seven countries. A total of 380 physicians were interviewed and completed patient record forms...


    pub_type: 杂志文章


    authors: Woitalla D,Mueller T,Russ H,Hock K,Haeger DA

    更新日期:2007-01-01 00:00:00

  • Prevalence of multiple sclerosis in Austria. Results of a nationwide survey.

    abstract::The epidemiology of multiple sclerosis (MS) in Austria is almost unknown. We evaluated the prevalence of MS in Austria using data from questionnaires completed by neurologists, comprising information on a total of 1,006 MS patients who attended 30 out-patient specialized clinics nationwide. Additional data were collec...


    pub_type: 杂志文章


    authors: Baumhackl U,Eibl G,Ganzinger U,Hartung HP,Mamoli B,Pfeiffer KP,Fazekas F,Vass K,Austrian MS Study Committee.

    更新日期:2002-09-01 00:00:00

  • Multicenter transversal two-phase study to determine a national prevalence of epilepsy in Algeria.

    abstract:BACKGROUND/AIMS:The prevalence of epilepsy in Algeria is unknown. The aims of this multicenter transversal study were to determine the national prevalence and clinical characteristics of epilepsy in the Algerian population. METHODS:This two-phase study was conducted in 5 circumscriptions and included 8,046 subjects ag...


    pub_type: 杂志文章,多中心研究


    authors: Moualek D,Pacha LA,Abrouk S,Kediha MI,Nouioua S,Aissa LA,Bellatache M,Belarbi S,Slimani S,Khennouf H,Fellahi L,El Amine Hamimed M,Benali N,Chekkour MC,Maamoun R,Dameche R,Assami S,Tazir M

    更新日期:2012-01-01 00:00:00

  • Cerebral haemodynamics in the elderly: the rotterdam study.

    abstract::Transcranial Doppler ultrasonography allows the non-invasive assessment of cerebral haemodynamics. Data on the frequency distribution of these parameters in the oldest old are scarce, which makes a distinction between physiological and pathophysiological ageing difficult. We studied the relation between cerebral haemo...


    pub_type: 杂志文章


    authors: Bakker SL,de Leeuw FE,den Heijer T,Koudstaal PJ,Hofman A,Breteler MM

    更新日期:2004-07-01 00:00:00

  • Different aetiology of familial low-grade and high-grade glioma? A nationwide cohort study of familial glioma.

    abstract::An increased risk for first-degree relatives (FDR) of glioma patients has previously been observed. The novel objective of this study was to investigate differences in familial risk among FDR of low-grade glioma (LGG) and high-grade glioma (HGG) cases, respectively. Two cohorts were constructed, one from 15,321 FDR of...


    pub_type: 杂志文章


    authors: Malmer B,Henriksson R,Grönberg H

    更新日期:2002-11-01 00:00:00

  • Sociodemographic factors and primary headache syndromes in a Saudi community.

    abstract:BACKGROUND AND PURPOSE:There is increasing evidence that the pathophysiologic mechanisms are different between migraine and tension-type headache. The aim of the study was to determine possible sociodemographic differences in Saudi Arabia subjects with headache. METHODOLOGY:A community-based door-to-door survey with i...


    pub_type: 杂志文章


    authors: Abdul Jabbar M,Ogunniyi A

    更新日期:1997-01-01 00:00:00

  • Hepatitis B vaccination and first central nervous system demyelinating event: a case-control study.

    abstract:OBJECTIVE:To investigate the relationship between hepatitis B (HB) vaccination and a first central nervous system (CNS) demyelinating event in adults. METHODS:In 1998, we conducted a multicentre, hospital-based case-control study which enrolled 402 cases of first CNS demyelinating event occurring between 1994 and 1995...


    pub_type: 杂志文章,多中心研究


    authors: Touzé E,Fourrier A,Rue-Fenouche C,Rondé-Oustau V,Jeantaud I,Bégaud B,Alpérovitch A

    更新日期:2002-07-01 00:00:00

  • Conscientiousness Is Associated with Lower Risk of Dementia among Black and White Older Adults.

    abstract:BACKGROUND:While some personality traits may reduce risk of dementia, this is controversial and has not been studied as much among diverse populations. We examined associations between 2 traits - Conscientiousness and Openness to Experience - and risk of dementia among black and white older adults. METHODS:We studied ...


    pub_type: 杂志文章


    authors: Kaup AR,Harmell AL,Yaffe K

    更新日期:2019-01-01 00:00:00

  • Hypertension increases the probability of Alzheimer's disease and of mild cognitive impairment in an Arab community in northern Israel.

    abstract:BACKGROUND:We aimed to determine whether vascular risk factors are associated with Alzheimer's disease (AD) and mild cognitive impairment (MCI) in an elderly Arab population. METHODS:An Arabic-speaking team performed a door-to-door survey of consecutive residents aged > or =65 years. We estimated the odds of AD or MCI...


    pub_type: 杂志文章


    authors: Israeli-Korn SD,Masarwa M,Schechtman E,Abuful A,Strugatsky R,Avni S,Farrer LA,Friedland RP,Inzelberg R

    更新日期:2010-01-01 00:00:00

  • Spatial Assessment of the Association between Long-Term Exposure to Environmental Factors and the Occurrence of Amyotrophic Lateral Sclerosis in Catalonia, Spain: A Population-Based Nested Case-Control Study.

    abstract:BACKGROUND:It is believed that an interaction between genetic and non-genetic factors may be involved in the development of amyotrophic lateral sclerosis (ALS). With the exception of exposure to agricultural chemicals like pesticides, evidence of an association between environmental risk factors and ALS is inconsistent...


    pub_type: 杂志文章


    authors: Povedano M,Saez M,Martínez-Matos JA,Barceló MA

    更新日期:2018-01-01 00:00:00

  • Plasma titers of antibodies against Epstein-Barr virus BZLF1 and risk of multiple sclerosis.

    abstract:BACKGROUND/AIMS:Results of recently conducted prospective studies have demonstrated that the presence of high titers of anti-EBNA-1 or anti-EBNA complex IgG antibodies in healthy individuals is a strong risk factor for multiple sclerosis (MS). Antibodies to BZLF1, the product of the homonymous early lytic gene, have be...


    pub_type: 杂志文章


    authors: Massa J,Munger KL,O'Reilly EJ,Falk KI,Ascherio A

    更新日期:2007-01-01 00:00:00

  • Stroke and ischemic heart disease mortality trends in Brazil from 1979 to 1996.

    abstract::Stroke and ischemic heart disease (IHD) mortality rates were analyzed in Brazilian subjects older than 30 years of age from 1979 to 1996. Population estimates were based on census surveys. Mortality data were obtained from the Ministry of Health. For stroke, the age-adjusted death rate (ADR) dropped from 200 to 164 an...


    pub_type: 杂志文章


    authors: de Padua Mansur A,de Fátima Marinho do Souza M,Favarato D,Avakian SD,Machado César LA,Mendes Aldrigui J,Franchini Ramires JA

    更新日期:2003-05-01 00:00:00

  • Significance of aphasia after first-ever acute stroke: impact on early and late outcomes.

    abstract:BACKGROUND:We assessed the incidence and determinants of aphasia attributable to first-ever acute stroke. We also investigated early and long-term mortality and 1-year dependence in post-stroke patients. METHODS:A 10-year prospective hospital-based study was conducted in the prefecture of Athens, Greece. RESULTS:In t...


    pub_type: 杂志文章


    authors: Tsouli S,Kyritsis AP,Tsagalis G,Virvidaki E,Vemmos KN

    更新日期:2009-01-01 00:00:00

  • Impact of age-related cerebral white matter changes on the transition to disability -- the LADIS study: rationale, design and methodology.

    abstract::Age-related white matter changes (ARWMC) on brain MRI have been associated with cognitive, motor, mood and urinary disturbances. These factors are known to contribute to disability in elderly people, but the impact of ARWMC and of their progression on the transition to disability is not determined. The LADIS (Leukoara...


    pub_type: 杂志文章,多中心研究


    authors: Pantoni L,Basile AM,Pracucci G,Asplund K,Bogousslavsky J,Chabriat H,Erkinjuntti T,Fazekas F,Ferro JM,Hennerici M,O'brien J,Scheltens P,Visser MC,Wahlund LO,Waldemar G,Wallin A,Inzitari D

    更新日期:2005-01-01 00:00:00