Assessing the clinical importance of statistically significant improvement in anti-dementia drug trials.

abstract：BACKGROUND:Exercise is hypothesized to improve cognition, physical performance, functional ability and quality of life, but evidence is scarce. Previous studies were of short duration, often underpowered and involving home-based light exercise programs in patients with undefined dementia. The aim of the ADEX ('Preservi...

journal_title：Neuroepidemiology

authors： Hoffmann K,Frederiksen KS,Sobol NA,Beyer N,Vogel A,Simonsen AH,Johannsen P,Lolk A,Terkelsen O,Cotman CW,Hasselbalch SG,Waldemar G

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Recent interest in antihypertensive agents, especially calcium channel blockers, has been sparked by the notion that these medications may be neuroprotective. A modest literature, with mixed results, has examined whether these medications might lower the odds or risk of Parkinson's disease (PD) or dementia. ...

journal_title：Neuroepidemiology

authors： Louis ED,Benito-León J,Bermejo-Pareja F,Neurological Disorders in Central Spain (NEDICES) Study Group.

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Amyotrophic lateral sclerosis (ALS) is a rare, rapidly progressive neurodegenerative disease. Despite wide variability in the incidence and prevalence of ALS, there is evidence of positive temporal trends and an increase in incidence with age. The aim of this study was to conduct a detailed epidemiological...

journal_title：Neuroepidemiology

authors： Demetriou CA,Hadjivasiliou PM,Kleopa KA,Christou YP,Leonidou E,Kyriakides T,Zamba-Papanicolaou E

更新日期：2017-01-01 00:00:00

abstract：:There is increasing evidence that oxidative stress is involved in cerebral aging and dementia. The objective of this review is to give a progress report on the more recent results of the various epidemiologic cohorts studied for the association between nutrition of older people, the evolution of cognitive performances...

journal_title：Neuroepidemiology

authors： Deschamps V,Barberger-Gateau P,Peuchant E,Orgogozo JM

更新日期：2001-02-01 00:00:00

abstract：:Seizures precipitated by the stimulus of hot water known as 'hot water epilepsy' (HWE) have been commonly reported from South India. The present report outlines certain descriptive epidemiological aspects of 78 cases from two rural satellite clinics of National Institute of Mental Health and Neuro Sciences (NIMHANS), ...

journal_title：Neuroepidemiology

authors： Gururaj G,Satishchandra P

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Providing a valid and sensitive measure of different domains of cognitive performance in epidemiologic studies of early old-age populations presents a methodological challenge, given the broad range of variability in cognitive functioning in this age group. OBJECTIVES:(1) To provide data on the distribution...

journal_title：Neuroepidemiology

authors： Wege N,Dlugaj M,Siegrist J,Dragano N,Erbel R,Jöckel KH,Moebus S,Weimar C,Heinz Nixdorf Recall Study Investigative Group.

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Short-term exposure to high levels of air pollution can increase stroke risk. In this study we investigated the short-term effects of air pollution on hospital admissions for stroke in a setting where pollutant levels are rather low. We also addressed methodological issues in evaluating the short-term effect...

journal_title：Neuroepidemiology

authors： Oudin A,Strömberg U,Jakobsson K,Stroh E,Björk J

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Brain tumours (BT) are one of the most frequent tumour types in young people, although little is known about their risk factors. OBJECTIVE:The objective of the current work was to review and summarize the scientific literature concerning exposure to environmental factors and BT risk in young people (<25 yea...

journal_title：Neuroepidemiology

authors： Zumel-Marne A,Castano-Vinyals G,Kundi M,Alguacil J,Cardis E

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Lifespan is 6-10 years shorter in multiple sclerosis (MS), but the reasons remain unclear. Using linked clinical- and population-based administrative health databases, we compared cause-specific mortality in an MS cohort to the general population. METHODS:MS patients in British Columbia (BC), Canada, were f...

journal_title：Neuroepidemiology

authors： Kingwell E,Zhu F,Evans C,Duggan T,Oger J,Tremlett H

更新日期：2020-01-01 00:00:00

abstract：:Parkinson's and Alzheimer's diseases are age-related degenerative disorders that share common clinical, pathological and biochemical features. Epidemiological studies demonstrate a similar distribution of the disease in place and time. Causes of death and populations at higher risk are similar. These findings suggest ...

journal_title：Neuroepidemiology

authors： Treves TA,Chandra V,Korczyn AD

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is increasing evidence that the pathophysiologic mechanisms are different between migraine and tension-type headache. The aim of the study was to determine possible sociodemographic differences in Saudi Arabia subjects with headache. METHODOLOGY:A community-based door-to-door survey with i...

journal_title：Neuroepidemiology

authors： Abdul Jabbar M,Ogunniyi A

更新日期：1997-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic and progressively disabling inflammatory autoimmune disorder of the central nervous system. MS has a multifactorial etiology and is triggered by environmental factors in individuals with complex genetic risk profiles. The epidemiology of MS changes with the spatial and temporal dis...

journal_title：Neuroepidemiology

authors： Al-Afasy HH,Al-Obaidan MA,Al-Ansari YA,Al-Yatama SA,Al-Rukaibi MS,Makki NI,Suresh A,Akhtar S

更新日期：2013-01-01 00:00:00

abstract：AIMS:In order to examine the hypothesis that elevated resting heart rate (RHR) is associated with impaired cognitive score, we investigated the relationship between RHR and cognitive score in middle-aged, elderly and old Danish subjects from the general population. METHODS:Composite cognitive scores derived from the r...

journal_title：Neuroepidemiology

authors： Wod M,Jensen MT,Galatius S,Hjelmborg JB,Jensen GB,Christensen K

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Mild cognitive impairment (MCI) has been suggested as a term for a boundary area between normal aging and dementia. This study was designed to determine the prevalence of MCI in the elderly in the Hebei province, China, and explore its related factors. METHODS:Participants included 2,601 community-dwelling ...

journal_title：Neuroepidemiology

authors： Xu S,Xie B,Song M,Yu L,Wang L,An C,Zhu Q,Han K,Zhao X,Zhang R,Dong L,Chai N,Gao Y,Zhang Q,Wang X

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Results of recently conducted prospective studies have demonstrated that the presence of high titers of anti-EBNA-1 or anti-EBNA complex IgG antibodies in healthy individuals is a strong risk factor for multiple sclerosis (MS). Antibodies to BZLF1, the product of the homonymous early lytic gene, have be...

journal_title：Neuroepidemiology

authors： Massa J,Munger KL,O'Reilly EJ,Falk KI,Ascherio A

更新日期：2007-01-01 00:00:00

abstract：:The incidence rate for primary intracranial neoplasms in the province of Trento (Italy) is 8.5/100,000/year, but the figures in the eleven administrative units ('comprensori') are different. The increased rates in C6 Val di Non and C10 Vallagarina are mainly due to the number of malignant tumors in the 45- to 64-year-...

journal_title：Neuroepidemiology

authors： Ferrari G,Lovaste MG

更新日期：1986-01-01 00:00:00

abstract：:An increased risk for first-degree relatives (FDR) of glioma patients has previously been observed. The novel objective of this study was to investigate differences in familial risk among FDR of low-grade glioma (LGG) and high-grade glioma (HGG) cases, respectively. Two cohorts were constructed, one from 15,321 FDR of...

journal_title：Neuroepidemiology

authors： Malmer B,Henriksson R,Grönberg H

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:Using data from a recent report that indicated a 2-fold higher risk of amyotrophic lateral sclerosis (ALS) among veterans of the 1991 Gulf War, we applied capture-recapture methodology to estimate possible under-ascertainment of ALS cases among deployed and non-deployed military personnel who were on active d...

journal_title：Neuroepidemiology

authors： Coffman CJ,Horner RD,Grambow SC,Lindquist J,VA Cooperative Studies Program Project #500.

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The 'Ten Questions' Questionnaire (TQQ) is used to detect severe neurological impairment in children living in resource-poor countries. Its usefulness has been established in Asia and the Caribbean, but there are a few published studies from Africa. We evaluated the TQQ as part of a larger study of neurologi...

journal_title：Neuroepidemiology

authors： Mung'ala-Odera V,Meehan R,Njuguna P,Mturi N,Alcock K,Carter JA,Newton CR

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Smoking increases the risk of multiple sclerosis (MS) and possibly disease progression. The reliability of self-reported smoking status is unknown in MS. We assessed the reliability of self-reported smoking status among participants in the North American Research Committee on Multiple Sclerosis (NARCOMS) Reg...

journal_title：Neuroepidemiology

authors： Marrie RA,Cutter G,Tyry T,Campagnolo D,Vollmer T

更新日期：2009-01-01 00:00:00

abstract：:Although cognitive screening test scores change with advanced age, the significance of these changes (particularly decline in score) needs to be defined in terms of general health and neuropsychological functioning. Such analysis was undertaken in a subgroup of 287 healthy older men (mean age at baseline = 70.7 years)...

journal_title：Neuroepidemiology

authors： Eslinger PJ,Swan GE,Carmelli D

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Genetic association studies conducted in admixed populations may be confounded by population stratification resulting in spurious associations. The purpose of this pilot study was to determine the presence and effect of population stratification in a case-control study of brain arteriovenous malformation (BA...

journal_title：Neuroepidemiology

authors： Kim H,Hysi PG,Pawlikowska L,Choudhry S,González Burchard E,Kwok PY,Sidney S,McCulloch CE,Young WL

更新日期：2008-01-01 00:00:00

abstract：:In the past several years, a substantial amount of new information on the epidemiology and pathophysiology of diabetes and vascular disease has become available. Autopsy studies suggest that diabetic patients are susceptible to cerebral small-artery disease and lacunar infarction and may be at risk for large-artery at...

journal_title：Neuroepidemiology

authors： Lukovits TG,Mazzone TM,Gorelick TM

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is the most common neurodegenerative disease after Alzheimer's dementia. Whereas the exact etiology of PD remains unknown, risk of developing PD seems to be related to a combination of genetic and environmental factors. This also includes abnormal exposure to trace elements of nutrit...

journal_title：Neuroepidemiology

authors： Adani G,Filippini T,Michalke B,Vinceti M

更新日期：2020-01-01 00:00:00

abstract：:The incidence rates of primary nervous system neoplasms in 5 districts (large administrative units) of Western Poland with a relatively homogeneous health care system but some contrasts in economic activity, as well as in 224 communes (smallest administrative units) located within these 5 districts, with a total popul...

journal_title：Neuroepidemiology

authors： Wender M,Pruchnik-Grabowska D,Kowal P,Tokarz E

更新日期：1985-01-01 00:00:00

abstract：INTRODUCTION:The excess stroke mortality among African Americans and Southerners is well known. Because a higher proportion of the population living in the 'Stroke Belt' is African American, then a portion of the estimated excess risk of stroke death traditionally associated with African-American race may be attributab...

journal_title：Neuroepidemiology

authors： Yang D,Howard G,Coffey CS,Roseman J

更新日期：2004-05-01 00:00:00

abstract：:Mortality rates from motor neuron disease (MND) in Spain were analysed for the years 1960-1989, a period in which 3,530 deaths were recorded from the disease and during which the crude annual mortality rate ranged between 0.35 and 0.95 deaths per 100,000 persons. Whilst the crude mortality rate fell by 54% during the ...

journal_title：Neuroepidemiology

authors： Neilson S,Robinson I,de Pedro-Cuesta J,Veiga-Cabo J

更新日期：1996-01-01 00:00:00

abstract：:In neuroepidemiologic research, there are many pitfalls to trap unwary investigators, whether the project is a survey, a case-control study, or some other type of study. We briefly discuss pitfalls relating to: research preliminaries (e.g., failure to decide on study objectives); personnel and training (e.g., deficien...

journal_title：Neuroepidemiology

authors： Anderson DW,Rocca WA,Rosário JA

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND AND METHODS:The high prevalence of epilepsy detected in rural Tanzania by Dr. Jilek-Aall since 1960, was verified by the World Health Organization (WHO) survey on neurological and seizure disorders. Neurologists and psychiatrists further interviewed both patients and controls using standard methods. The pres...

journal_title：Neuroepidemiology

authors： Matuja WB,Kilonzo G,Mbena P,Mwango'mbola RL,Wong P,Goodfellow P,Jilek-Aall L

更新日期：2001-10-01 00:00:00

abstract：:Several scores exist to clinically differentiate between ischemic and hemorrhagic stroke, but none has been developed in the emergency situation in which transient ischemic attack (TIA) and cerebral infarction might not yet be clearly distinguished. Information on 540 patients with ischemia (including TIA) or hemorrha...

journal_title：Neuroepidemiology

authors： Stürmer T,Schlindwein G,Kleiser B,Roempp A,Brenner H

更新日期：2002-01-01 00:00:00