Spectrum of disease in vascular cognitive impairment.

Abstract:

:The recognition that cognitive impairment of vascular origin is not limited to multi-infarct dementia has led to the development of several sets of new criteria for vascular dementia (VaD). We set out to define the spectrum of disease in patients presenting with vascular cognitive impairment (VCI). Of 412 patients consecutively seen at a memory clinic, 80 had VCI. These patients had vascular cognitive impairment not dementia (n = 19), VaD (n = 48), and mixed Alzheimer's disease-VaD (n = 13). Radiographic patterns were: white matter changes only (40%); multiple infarcts (30%); single strategic stroke (14%), and no identified lesion (16%). Of note, 19 (24%) of these patients meet none of the currently published criteria for VaD. To better understand and treat ischaemic causes of cognitive impairment, the concept of VaD should be expanded to include patients who do not meet traditional dementia criteria.

journal_name

Neuroepidemiology

journal_title

Neuroepidemiology

authors

Rockwood K,Howard K,MacKnight C,Darvesh S

doi

10.1159/000026219

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

248-54

issue

5

eissn

0251-5350

issn

1423-0208

pii

26219

journal_volume

18

pub_type

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