Abstract:
BACKGROUND:Transversal studies have underlined the association between the decline in autonomic nervous system (ANS) activity and all-cause mortality. However, the predictive value of ANS has never been prospectively assessed in a general population-based cohort. METHOD:The PROOF (PROgnostic indicator OF cardiovascular and cerebrovascular events) cohort study was designed to prospectively assess the predictive value of ANS activity level in the general population, with regard to cardiovascular and cerebrovascular events, and death. This predictive power will be compared with the usual and newly discovered risk factors for the purposes of developing a risk model. RESULTS:A prospective cohort of elderly subjects aged 65 years upon study entry were recruited from the electoral list of the city of Saint-Etienne, France. Three initial 2-year examination programs were scheduled for 7 years (2001-2007), followed by late events monitoring. At each examination, ANS activity was assessed along with clinical and biological cardiovascular risk factors, brain MRI, neuropsychological evaluation, physical activity profile, and sleep-related breathing disorders. The main study outcomes are stroke, myocardial infarction and death from any cause. A cohort consisting of 1,011 subjects aged 65.6 (0.8) years was constituted. CONCLUSION:Despite other selective characteristics, the associations between ANS activity and events will be applicable to other populations.
journal_name
Neuroepidemiologyjournal_title
Neuroepidemiologyauthors
Barthélémy JC,Pichot V,Dauphinot V,Celle S,Laurent B,Garcin A,Maudoux D,Kerleroux J,Lacour JR,Kossovsky M,Gaspoz JM,Roche Fdoi
10.1159/000108914subject
Has Abstractpub_date
2007-01-01 00:00:00pages
18-28issue
1-2eissn
0251-5350issn
1423-0208pii
000108914journal_volume
29pub_type
杂志文章abstract:BACKGROUND:The results of analytical studies show that the association between hypertension and the risk of Parkinson's disease (PD) remains controversial. METHOD:We searched studies related to the association between hypertension and the risk of PD. We pooled the ORs and risk ratios (RRs) with 95% confidence interval...
journal_title:Neuroepidemiology
pub_type: 杂志文章,meta分析
doi:10.1159/000496977
更新日期:2019-01-01 00:00:00
abstract::Some dementias, such as Creutzfeldt-Jakob disease, may result from transmissible agents. To assess the possibility of a blood-borne transmissible agent in Alzheimer's disease (AD), we compared informant-reported history of blood transfusions among 326 newly recognized probable AD cases and 330 control subjects of simi...
journal_title:Neuroepidemiology
pub_type: 临床试验,杂志文章,随机对照试验
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abstract:BACKGROUND:Anthropometric indexes are powerful indicators of the environment and the plasticity of the human body. This study aimed at exploring the anthropometric indexes that are associated with late-life cognition impairment among the elderly Chinese in the Shanghai Aging Study. METHODS:The height, weight, and sitt...
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pub_type: 杂志文章
doi:10.1159/000439569
更新日期:2015-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章,多中心研究
doi:10.1159/000081050
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journal_title:Neuroepidemiology
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
abstract::The multiple sclerosis (MS) mortality 1968-1977 in France, as reported by Alpérovitch and Bouvier, was tested for a possible correlation with a number of sociogeographic variables from relevant periods. The MS rate was associated with the main industry groups (metal processing and textile industry), with industry as a...
journal_title:Neuroepidemiology
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journal_title:Neuroepidemiology
pub_type: 杂志文章,meta分析,评审
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journal_title:Neuroepidemiology
pub_type: 杂志文章
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journal_title:Neuroepidemiology
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1159/000274807
更新日期:2010-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:Neuroepidemiology
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doi:10.1159/000110212
更新日期:1985-01-01 00:00:00
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更新日期:2010-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110902
更新日期:1992-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000348320
更新日期:2013-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110980
更新日期:1992-01-01 00:00:00
abstract::The Global Burden of Disease (GBD) study is a long-standing effort to report consistent and comprehensive measures of disease burden for the world. In this paper, we describe the methods used to estimate the global burden of stroke for the GBD 2013 study. Pathologic subtypes of stroke are modeled separately for two mu...
journal_title:Neuroepidemiology
pub_type: 杂志文章,评审
doi:10.1159/000441083
更新日期:2015-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110139
更新日期:1988-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110284
更新日期:1991-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000477300
更新日期:2017-01-01 00:00:00