Abstract:
:The relationship between smoking status and incident Alzheimer's disease (AD) was investigated in a random stratified sample of a biracial community in Chicago. Analyses are based on 1,064 persons (of 1,134 evaluated) who had data on smoking status, disease incidence, and key covariates such as apolipoprotein allele status. During a mean of about 4 years of follow-up, 170 persons met criteria for incident AD. Current smoking was associated with increased risk of incident AD (OR = 3.4, 95% CI = 1.4-8.0) compared to persons who never smoked. There was no apparent increase in risk of AD for former smokers compared to persons who never smoked (OR = 0.9, 95% CI = 0.5-1.7). Apolipoprotein E allele status modified this association in that former smokers with a upsilon4 allele were less likely to develop AD (p = 0.04) than those who never smoked. Former smokers also appeared to have a reduced risk of developing AD as their pack-years of smoking increased (p = 0.02)such that the odds of developing AD increased by 50% for every 10 years of smoking cessation (OR = 1.3, CI = 0.9-1.7). The results suggest that older people who currently smoke are more likely to develop AD compared to those who never smoked; the relation between those who used to smoke but quit and the risk of AD is complex and requires further research.
journal_name
Neuroepidemiologyjournal_title
Neuroepidemiologyauthors
Aggarwal NT,Bienias JL,Bennett DA,Wilson RS,Morris MC,Schneider JA,Shah RC,Evans DAdoi
10.1159/000091654subject
Has Abstractpub_date
2006-01-01 00:00:00pages
140-6issue
3eissn
0251-5350issn
1423-0208pii
91654journal_volume
26pub_type
杂志文章abstract:OBJECTIVE:Poorer socioeconomic conditions early in life have been linked with memory, attention and learning deficits in adulthood, as well as with specific areas of educational achievement. It remains unclear, however, whether these distal associations are mediated by more current socioeconomic factors. In this study,...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000325779
更新日期:2011-01-01 00:00:00
abstract::In this report we describe the establishment of a Neuro-Oncology Register (NOR) at the University Hospital of Maastricht, The Netherlands. The register includes data on numbers and types of primary central nervous system (CNS) tumours and neurological complications of systemic cancer. One of the objectives of the regi...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110939
更新日期:1992-01-01 00:00:00
abstract::Although cognitive screening test scores change with advanced age, the significance of these changes (particularly decline in score) needs to be defined in terms of general health and neuropsychological functioning. Such analysis was undertaken in a subgroup of 287 healthy older men (mean age at baseline = 70.7 years)...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000067113
更新日期:2003-01-01 00:00:00
abstract:INTRODUCTION:Amyotrophic lateral sclerosis (ALS) is a rare, rapidly progressive neurodegenerative disease. Despite wide variability in the incidence and prevalence of ALS, there is evidence of positive temporal trends and an increase in incidence with age. The aim of this study was to conduct a detailed epidemiological...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000477126
更新日期:2017-01-01 00:00:00
abstract::The epidemiology of multiple sclerosis (MS) in Austria is almost unknown. We evaluated the prevalence of MS in Austria using data from questionnaires completed by neurologists, comprising information on a total of 1,006 MS patients who attended 30 out-patient specialized clinics nationwide. Additional data were collec...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000065640
更新日期:2002-09-01 00:00:00
abstract::This paper describes a proposed study to investigate the incidence of dementia in a population of over 75 year olds in Melton Mowbray, Leicestershire, England. The study population (n = 438) underwent a detailed psychiatric assessment using the Cambridge Examination for Mental Disorders of the Elderly (CAMDEX) as the ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110980
更新日期:1992-01-01 00:00:00
abstract::According to studies done before 1980, the multiple sclerosis (MS) prevalence rate in Italy ranged from 7.2 to 27.1 cases per 100,000 inhabitants. More recent work has consistently put the MS prevalence rate to over 30 cases per 100,000 inhabitants. If these recent data are confirmed in the future, Italy can no longer...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110249
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Mild cognitive impairment (MCI) has been suggested as a term for a boundary area between normal aging and dementia. This study was designed to determine the prevalence of MCI in the elderly in the Hebei province, China, and explore its related factors. METHODS:Participants included 2,601 community-dwelling ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000357374
更新日期:2014-01-01 00:00:00
abstract::The recognition that cognitive impairment of vascular origin is not limited to multi-infarct dementia has led to the development of several sets of new criteria for vascular dementia (VaD). We set out to define the spectrum of disease in patients presenting with vascular cognitive impairment (VCI). Of 412 patients con...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000026219
更新日期:1999-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章,meta分析
doi:10.1159/000494291
更新日期:2019-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000502357
更新日期:2020-01-01 00:00:00
abstract::Between 1992 and 2040, the United States nonwhite elderly population is expected to grow from 3.3 to 14.1 million. In order to assess the implications of this increase on the mortality from neurodegenerative diseases in the United States, we used Census Bureau population estimates to formulate projections of the annua...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110377
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND AND AIMS:The impact of statin on dementia risk reduction has been a subject of debate over the last decade, but the evidence remains inconclusive. Therefore, we performed a meta-analysis of relevant observational studies to quantify the magnitude of the association between statin therapy and the risk of deme...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000503105
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Despite decades of research, there are no national estimates of the incidence or prevalence of spinal cord injury (SCI) in Canada. Our objective was to utilize the best available data to estimate the incidence and prevalence of traumatic SCI (TSCI) and non-traumatic SCI (NTSCI) in Canada for 2010. METHODS:I...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000336014
更新日期:2012-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章,多中心研究
doi:10.1159/000059520
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:No epidemiological studies on the prevalence of compressive neuropathy have been undertaken in Arab countries. The aim of the study was to estimate the prevalence of the most common types of compressive neuropathies in Qena governorate/Egypt. METHODS:The study was part of a community-based survey carried ou...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000444641
更新日期:2016-01-01 00:00:00
abstract::The black Caribbean population continues to grow in the US and little is known about stroke etiologies in that community. We examined stroke subtypes in 175 consecutive Haitian-born patients living in Miami, admitted for acute stroke. Ischemic stroke was diagnosed in 72%. Small vessel occlusion was the most frequent s...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000087449
更新日期:2005-01-01 00:00:00
abstract::The knowledge of the prevalence of spinal cord disorders (SCD) is important to understand specific causes in each part of the worldand to allow to potentially adapt health care and public policy including law enforcement to the main causes. SCD have important personal, biopsychological, socio-economic, short-term and ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000348320
更新日期:2013-01-01 00:00:00
abstract::Seizures precipitated by the stimulus of hot water known as 'hot water epilepsy' (HWE) have been commonly reported from South India. The present report outlines certain descriptive epidemiological aspects of 78 cases from two rural satellite clinics of National Institute of Mental Health and Neuro Sciences (NIMHANS), ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110929
更新日期:1992-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000328867
更新日期:2011-01-01 00:00:00
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journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000365991
更新日期:2014-01-01 00:00:00
abstract::Recent reports of declining trends in mortality rates from cerebrovascular disease are based on underlying cause of death as stated on the death certificate, and may contain inaccuracies because death certificates are often completed without reference to all information in medical records, and because of changes in co...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110160
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Studies on dyskinesia and Parkinson's syndrome associated with chronic kidney disease or end-stage renal disease (ESRD) have been mainly limited to case reports or case series studies. This population-based study investigated the risk of Parkinson's disease in patients with ESRD. METHODS:From a universal in...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000358921
更新日期:2014-01-01 00:00:00
abstract::The Canadian Study of Health and Aging (CSHA) provided a population-based estimate of the prevalence of dementia of 8% for those aged 65 and older. Other studies have produced both higher and lower prevalence estimates. Factors that may contribute to these differences include: the use of or the reliance on neuropsycho...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000026247
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Limited epidemiological data exist about amyotrophic lateral sclerosis (ALS) in the United States (US). The Agency for Toxic Substances and Disease Registry maintains the National ALS Registry and funded state and metropolitan surveillance projects to obtain reliable, timely information about ALS in defined ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000365850
更新日期:2014-01-01 00:00:00
abstract::We carried out a door-to-door survey in rural areas of the Cordillera Province, Bolivia, to determine the prevalence of the most common neurological diseases in a sample of about 10,000 inhabitants. A team of non-doctor health workers administered a standard screening instrument for neurological diseases, a slightly m...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000048624
更新日期:2002-03-01 00:00:00
abstract::Homocysteine is a metabolite of methionine that may be remethylated by enzymes requiring folate and cobalamin (vitamin B12) to again form methionine or catabolized by the pyridoxine (vitamin B6) dependent enzyme, cystathionine beta synthase (CBS) to form cysteine (fig. 1) [1]. Homocysteine exists as a combination of v...
journal_title:Neuroepidemiology
pub_type: 杂志文章,评审
doi:10.1159/000026169
更新日期:1998-01-01 00:00:00
abstract::All death certificates with amyotrophic lateral sclerosis (ALS) or motor neuron disease (MND) as the primary or underlying cause occurring among Kentucky residents between 1964 and 1984 were manually reviewed. Geographic variability within Kentucky was evident for three intervals, 1964-1967, 1968-1978, and 1979-1984, ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000110168
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:Using data from a recent report that indicated a 2-fold higher risk of amyotrophic lateral sclerosis (ALS) among veterans of the 1991 Gulf War, we applied capture-recapture methodology to estimate possible under-ascertainment of ALS cases among deployed and non-deployed military personnel who were on active d...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000083297
更新日期:2005-01-01 00:00:00
abstract::We studied the prevalence of Parkinson's disease (PD) in Gypsies and Caucasians in Bulgaria. Cases were ascertained by examination in a clinic, a screening questionnaire and a door-to-door survey in a region of Sofia, Bulgaria. The prevalence of PD in the Gypsies was found to be 16/100,000 based on 1 case compared to ...
journal_title:Neuroepidemiology
pub_type: 杂志文章
doi:10.1159/000026257
更新日期:2000-07-01 00:00:00