Prospective observational study of the non-invasive assessment of immediate postoperative pain using the analgesia/nociception index (ANI).

Abstract:

BACKGROUND:The analgesia/nociception index (ANI), a 0-100 non-invasive index calculated from heart rate variability, reflects the analgesia/nociception balance during general anaesthesia. The aim of this study was to evaluate the ANI in the assessment of immediate postoperative pain in adult patients undergoing general anaesthesia. METHODS:Two-hundred patients undergoing scheduled surgery or endoscopy with general anaesthesia were included in this prospective observational study. Pain intensity was assessed using a 0-10 numerical rating scale (NRS) after arousal from general anaesthesia. Receiver-operating characteristic (ROC) curves were built to assess the performance of ANI to detect patients with NRS>3 and NRS ≥ 7 on arrival in the postoperative care unit. RESULTS:A negative linear relationship was observed between ANI and NRS (ANI=-5.2 × NRS+77.9, r(2)=0.41, P<0.05). At the threshold of 57, the sensitivity and specificity of ANI to detect patients with NRS>3 were 78 and 80%, respectively, with a negative predictive value of 88%, corresponding to an area under the ROC curve (AUC) of 0.86. At the threshold of 48, the sensitivity and specificity of ANI to detect NRS ≥ 7 were 92 and 82%, respectively, with a negative predictive value of 99%, corresponding to a ROC curve AUC of 0.91. CONCLUSIONS:A measurement of ANI during the immediate postoperative period is significantly correlated with pain intensity. The measurement of ANI appears to be a simple and non-invasive method to assess immediate postoperative analgesia.

journal_name

Br J Anaesth

authors

Boselli E,Daniela-Ionescu M,Bégou G,Bouvet L,Dabouz R,Magnin C,Allaouchiche B

doi

10.1093/bja/aet110

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

453-9

issue

3

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)32403-0

journal_volume

111

pub_type

杂志文章
  • Evaluation of flexible (part-time) training in anaesthesia.

    abstract::One hundred and six former or current flexible trainees in anaesthesia responded to a questionnaire evaluating their part-time training (a response rate of 71%). They were compared with a group of 32 flexible trainees in obstetrics and gynaecology. Anaesthetists were more satisfied than obstetricians and gynaecologist...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/81.2.268

    authors: Scriven PM

    更新日期:1998-08-01 00:00:00

  • Accuracy of new gas flowmeters.

    abstract::The accuracy of five new oxygen and nitrous oxide flowmeter units was investigated using the bubble meter method. The results were compared with those previously found in flowmeters withdrawn from clinical use. New oxygen flowmeters demonstrated less inaccuracies than old flowmeters. No differences were found between ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/52.1.97

    authors: Waaben J,Brinkløv MM,Stokke DB

    更新日期:1980-01-01 00:00:00

  • Induction dose-response of propofol in unpremedicated children.

    abstract::The induction dose requirements of propofol were compared in three age groups in 300 unpremedicated healthy Chinese children: group A, younger than 2 yr (n = 48); group B, 2-5 yr (n = 117); group C, 6-12 yr (n = 135). Patients in each group were allocated randomly to receive one of eight doses of propofol (1.2, 1.4, 1...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/68.1.64

    authors: Aun CS,Short SM,Leung DH,Oh TE

    更新日期:1992-01-01 00:00:00

  • Randomized comparison of three transducer orientation approaches for ultrasound guided internal jugular venous cannulation.

    abstract:BACKGROUND:Ultrasound-guided internal jugular venous access increases the rate of successful cannulation and reduces the incidence of complications, compared with the landmark technique. Three transducer orientation approaches have been proposed for this procedure: short-axis (SAX), long-axis (LAX) and oblique-axis (OA...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aev399

    authors: Batllori M,Urra M,Uriarte E,Romero C,Pueyo J,López-Olaondo L,Cambra K,Ibáñez B

    更新日期:2016-03-01 00:00:00

  • Postoperative serum cholinesterase activity following successful renal transplantation.

    abstract::For 6 months after renal transplant serum cholinesterase concentrations were measured in 10 patients. The value decreased in the first 15 days after operation, but was normal thereafter. Liver function tests were normal throughout the study; the cholinesterase changes were independent of immunosuppressive therapy. ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/51.9.881

    authors: Ryan DW

    更新日期:1979-09-01 00:00:00

  • Perianaesthetic risks and outcomes of abdominal surgery for metastatic carcinoid tumours.

    abstract::Patients with metastatic carcinoid tumours often undergo surgical procedures to reduce the tumour burden and associated debilitating symptoms. These procedures and anaesthesia can precipitate a life-threatening carcinoid crisis. To assess perioperative outcomes, we studied retrospectively the medical records of adult ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/87.3.447

    authors: Kinney MA,Warner ME,Nagorney DM,Rubin J,Schroeder DR,Maxson PM,Warner MA

    更新日期:2001-09-01 00:00:00

  • Meperidine-induced serotonin syndrome in a susceptible patient.

    abstract::We present a patient with a history of clomipramine-induced serotonin syndrome 5 yr prior who developed serotonin syndrome after a single dose of meperidine. This report heightens appreciation of population at risk and also recognition of potential toxicity in meperidine. ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aep167

    authors: Guo SL,Wu TJ,Liu CC,Ng CC,Chien CC,Sun HL

    更新日期:2009-09-01 00:00:00

  • Ventilatory effects of morphine, pethidine and methadone in children.

    abstract::The ventilatory effects of single i.v. doses of morphine 0.1 mg kg-1, pethidine 0.67 mg kg-1 and methadone 0.1 mg kg-1 were compared after ophthalmic surgery in an open, randomized study in 30 children aged 3-8 yr. Ventilatory changes after each drug had distinctive profiles, with appreciable individual variation. Acu...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/70.4.414

    authors: Hamunen K

    更新日期:1993-04-01 00:00:00

  • Comparison of the effects of spinal anaesthesia and general anaesthesia on postoperative oxygenation and perioperative mortality.

    abstract::One hundred patients presenting for surgical treatment of fractured neck of femur were allocated to receive either spinal (SAB) or general (GA) anaesthesia. Before operation, the mean PaO2 was 9.04 kPa. There was a significant decrease in PaO2 of 0.68 kPa in GA group at 1 h after operation, while blood-gas values were...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/52.1.49

    authors: McKenzie PJ,Wishart HY,Dewar KM,Gray I,Smith G

    更新日期:1980-01-01 00:00:00

  • Intranasal midazolam for premedication of children undergoing day-case anaesthesia: comparison of two delivery systems with assessment of intra-observer variability.

    abstract::Midazolam is often used for paediatric premedication. We have compared two methods of administering midazolam intranasally in 44 surgical day-case children allocated randomly to receive midazolam 0.2 mg kg-1 as drops or midazolam 0.1 mg kg-1 from an intranasal spray device. Behaviour was recorded on a four-point scale...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/81.6.865

    authors: Griffith N,Howell S,Mason DG

    更新日期:1998-12-01 00:00:00

  • The role of an anaesthetist in a field hospital during the cholera epidemic among Rwandan refugees in Goma.

    abstract::In 1849 John Snow, already the leading anaesthetic practitioner and innovator of his day, made a historic contribution to the epidemiology of infectious disease by his famous study of the distribution of cholera around the area of Broad Street in London. We report on our experience as anaesthetists in a field hospital...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/75.6.810

    authors: Ginosar Y,Shapira SC

    更新日期:1995-12-01 00:00:00

  • Extracorporeal circuit sequestration of fentanyl and alfentanil.

    abstract::Fentanyl or alfentanil, in doses approximating to those used in clinical practice, was added to the priming fluid of an extracorporeal circuit before the institution of cardiopulmonary bypass (CPB). The concentrations of both drugs in the priming fluid were measured over a 20-min period. The concentration of fentanyl ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/58.9.947

    authors: Skacel M,Knott C,Reynolds F,Aps C

    更新日期:1986-09-01 00:00:00

  • Haemodynamic disturbances during anaesthesia in a patient receiving calcium channel blockers.

    abstract::Haemodynamic changes (supraventricular tachycardia, decreases in arterial pressure) were observed during laryngoscopy and intubation of the trachea in a patient receiving nifedipine and verapamil. Before the induced stresses of laryngoscopy and tracheal intubation, these drugs had controlled the patient's arterial pre...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/58.3.357

    authors: Gorven AM,Cooper GM,Prys-Roberts C

    更新日期:1986-03-01 00:00:00

  • Utility of clinical risk predictors for preoperative cardiovascular risk prediction.

    abstract::Cardiovascular risk prediction using clinical risk factors is integral to both the European and the American algorithms for preoperative cardiac risk assessment and perioperative management for non-cardiac surgery. We have reviewed these risk factors and their ability to guide clinical decision making. We examine thei...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/aer194

    authors: Biccard BM,Rodseth RN

    更新日期:2011-08-01 00:00:00

  • Buprenorphine induces ceiling in respiratory depression but not in analgesia.

    abstract:BACKGROUND:We measured the effect of two weight adjusted i.v. doses (0.2 mg per 70 kg and 0.4 mg per 70 kg) of the potent opioid buprenorphine on analgesia and respiratory depression in healthy volunteers. The aim of the study was to compare buprenorphine's behaviour with respect to the occurrence of ceiling (or appare...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/ael051

    authors: Dahan A,Yassen A,Romberg R,Sarton E,Teppema L,Olofsen E,Danhof M

    更新日期:2006-05-01 00:00:00

  • Prospective validation of a new airway management algorithm and predictive features of intubation difficulty.

    abstract:BACKGROUND:Some patients have features that indicate possible difficulty with direct laryngoscopy for tracheal intubation. Prediction of the likely outcome and selection of patients for an enhanced management algorithm would reduce the possible harm from failed intubation attempts. METHODS:Adult elective patients were...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1016/j.bja.2018.09.021

    authors: Cook F,Lobo D,Martin M,Imbert N,Grati H,Daami N,Cherait C,Saïdi NE,Abbay K,Jaubert J,Younsi K,Bensaid S,Ait-Mamar B,Slavov V,Mounier R,Goater P,Bloc S,Catineau J,Abdelhafidh K,Haouache H,Dhonneur G

    更新日期:2019-02-01 00:00:00

  • Regional anaesthesia for carotid endarterectomy: an audit over 10 years.

    abstract:BACKGROUND:The aim of this retrospective study was to compare the failure rates and the frequency of anaesthesia-related complications of two different methods of regional anaesthesia used for carotid endarterectomy--cervical epidural (CE) anaesthesia and cervical plexus block (CPB). METHODS:The study included 1828 ca...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,多中心研究

    doi:10.1093/bja/aem171

    authors: Hakl M,Michalek P,Sevcík P,Pavlíková J,Stern M

    更新日期:2007-09-01 00:00:00

  • Measurement of lung volume by multiple indicator dilution. Testing a modelled hypothesis with on-line computation.

    abstract::Respiratory mass spectrometry and on-line computation were used to estimate lung volume in normal subjects by a rebreathing technique, using oxygen, nitrogen and argon as indicators. The computation had previously been tested in a numerical model. In real normal lungs, it performed well enough for practical purposes, ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/56.5.509

    authors: Black AM,Scott IL,Hahn CE,Maynard P,Baker AB

    更新日期:1984-05-01 00:00:00

  • Solvent for etomidate may cause pain and adverse effects.

    abstract::We tested the hypothesis that the solvent for etomidate was a factor in the incidence of pain and other side effects after injection, and that these were associated with histamine release. Nine of 10 volunteers who received etomidate in a propylene glycol formulation reported moderate to severe pain on injection; only...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/83.3.464

    authors: Doenicke AW,Roizen MF,Hoernecke R,Lorenz W,Ostwald P

    更新日期:1999-09-01 00:00:00

  • Isoflurane exerts antinociceptive and hypnotic properties at all ages in Fischer rats.

    abstract:BACKGROUND:Some anaesthetic agents exhibit an age-dependent analgesic effect, for example nitrous oxide, which is ineffective in newborn rats. We investigated whether a similar time dependency existed for the responses to the volatile anaesthetic isoflurane. METHODS:The analgesic and hypnotic properties of isoflurane ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aei182

    authors: Sanders RD,Patel N,Hossain M,Ma D,Maze M

    更新日期:2005-09-01 00:00:00

  • Cardiac μ-opioid receptor contributes to opioid-induced cardioprotection in chronic heart failure.

    abstract:BACKGROUND:The therapeutic potential of cardiac μ-opioid receptors in ischaemia-reperfusion (I/R) injury during opioid-modulating diseases, such as heart failure, is unknown. We aimed to explore the changes of cardiac μ-opioid receptor expression during heart failure, and its role in opioid-induced cardioprotection. M...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1016/j.bja.2017.11.110

    authors: He SF,Jin SY,Yang W,Pan YL,Huang J,Zhang SJ,Zhang L,Zhang Y

    更新日期:2018-07-01 00:00:00

  • Ondansetron and droperidol in the prevention of postoperative nausea and vomiting.

    abstract::We have performed a prospective, randomized, double-blind clinical study to assess the efficacy of ondansetron, droperidol, or both, in preventing postoperative emesis. We studied 242 patients undergoing biliary or gynaecological surgery under general anaesthesia. Shortly before induction of anaesthesia, patients rece...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/83.5.813

    authors: Bugedo G,Gonzalez J,Asenjo C,De la Cuadra JC,Gajardo A,Castillo L,Muñoz H,Dagnino J

    更新日期:1999-11-01 00:00:00

  • Preservation of the pulmonary vasoconstrictor response to alveolar hypoxia during the administration of halothane to dogs.

    abstract::The action of halothane on the pulmonary vasoconstrictor response to unilateral alveolar hypoxia was studied in two groups of dogs. In the first group the redistribution of blood flow between the two lungs was studied with a radioactive isotope method, which provided intermittent measurements, whilst in the second gro...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/50.12.1185

    authors: Sykes MK,Gibbs JM,Loh L,Marin JB,Obdrzalek J,Arnot RN

    更新日期:1978-12-01 00:00:00

  • Maternal temperature regulation during extradural analgesia for labour.

    abstract::We have studied the effect of analgesia on maternal temperature (oral and tympanic membrane) progression in 53 women during normal spontaneous labour. Three groups were studied: two received extradural analgesia with a continuous infusion of 0.25% bupivacaine with or without the addition of fentanyl; the third group r...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/67.5.565

    authors: Camann WR,Hortvet LA,Hughes N,Bader AM,Datta S

    更新日期:1991-11-01 00:00:00

  • Infusion thrombophlebitis.

    abstract::Infusion thrombophlebitis is a common complication of i.v. infusions. Many factors appear to be involved in its aetiology, of which the duration of infusion, the drugs infused and the solution(s) infused are the most important. Effective prophylaxis should be based on an understanding of the possible pathophysiology. ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/57.2.220

    authors: Lewis GB,Hecker JF

    更新日期:1985-02-01 00:00:00

  • Pharmacokinetics and pulmonary extraction of clevidipine, a new vasodilating ultrashort-acting dihydropyridine, during cardiopulmonary bypass.

    abstract::Clevidipine is a new vascular-selective, calcium channel antagonist of the dihydropyridine type with an ester side chain susceptible to esterase metabolism. In healthy volunteers, it has high clearance (0.069 litres min-1 kg-1) with a small volume of distribution at steady state (0.19 litres kg-1). The half-lives of t...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/85.5.683

    authors: Vuylsteke A,Milner Q,Ericsson H,Mur D,Dunning J,Jolin-Mellgård A,Nordlander M,Latimer R

    更新日期:2000-11-01 00:00:00

  • Soluble E-cadherin concentrations in patients with systemic inflammatory response syndrome and multiorgan dysfunction syndrome.

    abstract::We have assessed the role of the cell-cell adhesion molecule, E-cadherin, in the pathogenesis of multiorgan failure in 24 intensive care patients with sepsis and varying degrees of organ dysfunction, compared with 21 healthy subjects. Plasma soluble E-cadherin (sE-cadherin) was measured by enzyme immunoassay. The medi...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/76.5.629

    authors: Pittard AJ,Banks RE,Galley HF,Webster NR

    更新日期:1996-05-01 00:00:00

  • Mivacurium in the myasthenic patient.

    abstract::We have used mivacurium in four myasthenic patients presenting for thymectomy. Supramaximal single twitch stimulation was applied to the ulnar nerve at the wrist and the force of contraction of the adductor pollicis was measured. After an initial bolus dose of 30 micrograms kg-1 (approximately one-fifth of the normal ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/73.4.494

    authors: Paterson IG,Hood JR,Russell SH,Weston MD,Hirsch NP

    更新日期:1994-10-01 00:00:00

  • The history of controlled hypotension.

    abstract::As the physiology of deliberate hypotension has been unravelled, and as each new pharmacological agent has become available which either depresses or blocks peripheral vascular tone, depresses myocardial performance, or interferes with the conducting tissues within the myocardium, its possible incorporation into the a...

    journal_title:British journal of anaesthesia

    pub_type: 历史文章,杂志文章

    doi:10.1093/bja/47.7.745

    authors: Leigh JM

    更新日期:1975-07-01 00:00:00

  • Effect of preoperative amino acid infusion on thermoregulatory response during spinal anaesthesia.

    abstract:BACKGROUND:Intravenous amino acid infusion during general anaesthesia prevents decreases in core temperature resulting from increased energy expenditure and heat accumulation. METHODS:We investigated whether such stimulation also occurs during spinal anaesthesia, which blocks sympathetic nervous activity. We examined ...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Kasai T,Nakajima Y,Matsukawa T,Ueno H,Sunaguchi M,Mizobe T

    更新日期:2003-01-01 00:00:00