Soluble E-cadherin concentrations in patients with systemic inflammatory response syndrome and multiorgan dysfunction syndrome.

Abstract:

:We have assessed the role of the cell-cell adhesion molecule, E-cadherin, in the pathogenesis of multiorgan failure in 24 intensive care patients with sepsis and varying degrees of organ dysfunction, compared with 21 healthy subjects. Plasma soluble E-cadherin (sE-cadherin) was measured by enzyme immunoassay. The median concentration of sE-cadherin in normal subjects was 3.21 micrograms ml-1 compared with 6.00 micrograms ml-1 in patients with sepsis and organ dysfunction (P = 0.0019). There was no statistically significant difference in concentrations of sE-cadherin in survivors compared with non-survivors. Concentrations of sE-cadherin tended to increase with the severity of organ failure. We conclude that sE-cadherin is increased in inflammation and injury, and may be related to the degree of multiorgan failure after sepsis.

journal_name

Br J Anaesth

authors

Pittard AJ,Banks RE,Galley HF,Webster NR

doi

10.1093/bja/76.5.629

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

629-31

issue

5

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)43475-1

journal_volume

76

pub_type

杂志文章
  • Comparison of sampling techniques for studies of nitrous oxide pollution.

    abstract::The retention of nitrous oxide in samples of nitrous oxide in air held in disposable plastic syringes, glass syringes and custom-made nylon film bags was studied by means of gas chromatography at intervals of 90 min, 24, 48 and 120 h after filling the containers. After 24 h the nylon bags retained a mean concentration...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/50.11.1109

    authors: Austin JC,Shaw R,Crichton R,Cleaton-Jones PE,Moyes D

    更新日期:1978-11-01 00:00:00

  • The use of a digital computer for the on-line real-time assessment of neuromuscular blockade in anaesthetized man.

    abstract::A computer program written mainly in a high level language (ALGOL), but with the sampling routine and certain calculations written in assembly language (SIR), has been developed to assess neuromuscular blockade in anaesthetized man by means of an Elliott 903 digital computer. The program allows the on-line real-time a...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/47.10.1097

    authors: Perry IR,Worsley R,Sugai N,Payne JP

    更新日期:1975-10-01 00:00:00

  • Cardiovascular effects and regional clearances of i.v. bupivacaine in sheep: enantiomeric analysis.

    abstract::All currently available aminoacylaniline local anaesthetics, except lignocaine, contain a chiral centre but are used as racemates, a fact usually ignored in pharmacokinetic studies. This study reports the cardiovascular effects, and the regional and total body clearances of the enantiomers of bupivacaine determined at...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/67.3.247

    authors: Rutten AJ,Mather LE,McLean CF

    更新日期:1991-09-01 00:00:00

  • Plasma concentration of morphine after i.m., extradural and intrathecal administration.

    abstract::Seventeen patients received morphine 0.2 mgkg-1 in a 10% dextrose solution i.m. (n = 5), extradurally (n = 6) and intrathecally (n = 6) for pain after operation. Morphine was measured in plasma by radioimmunoassay. Plasma immunoreactive morphine concentration was significantly less after intrathecal administration aft...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/53.9.911

    authors: Chauvin M,Samii K,Schermann JM,Sandouk P,Bourdon R,Viars P

    更新日期:1981-09-01 00:00:00

  • Four phases of intravenous fluid therapy: a conceptual model.

    abstract::I.V. fluid therapy plays a fundamental role in the management of hospitalized patients. While the correct use of i.v. fluids can be lifesaving, recent literature demonstrates that fluid therapy is not without risks. Indeed, the use of certain types and volumes of fluid can increase the risk of harm, and even death, in...

    journal_title:British journal of anaesthesia

    pub_type: 共识发展会议,杂志文章,评审

    doi:10.1093/bja/aeu300

    authors: Hoste EA,Maitland K,Brudney CS,Mehta R,Vincent JL,Yates D,Kellum JA,Mythen MG,Shaw AD,ADQI XII Investigators Group.

    更新日期:2014-11-01 00:00:00

  • Components of the inspiratory-arterial isoflurane partial pressure difference.

    abstract::We have measured the partial pressure of isoflurane simultaneously in inspired gas (PIiso), end-expired gas (PE'iso), mixed-expired gas (PEiso), arterial (Paiso) and mixed venous blood (Pviso) in six patients (aged 57-79 yr) anaesthetized with nitrous oxide, oxygen and isoflurane before surgery and after PE'iso had be...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/70.6.605

    authors: Landon MJ,Matson AM,Royston BD,Hewlett AM,White DC,Nunn JF

    更新日期:1993-06-01 00:00:00

  • Influence of obesity on propofol pharmacokinetics: derivation of a pharmacokinetic model.

    abstract:BACKGROUND:The objective of this study was to develop a pharmacokinetic (PK) model to characterize the influence of obesity on propofol PK parameters. METHODS:Nineteen obese ASA II patients undergoing bariatric surgery were studied. Patients received propofol 2 mg kg(-1) bolus dose followed by a 5-20-40-120 min, 10-8-...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aeq195

    authors: Cortínez LI,Anderson BJ,Penna A,Olivares L,Muñoz HR,Holford NH,Struys MM,Sepulveda P

    更新日期:2010-10-01 00:00:00

  • Effect of sevoflurane anaesthesia on plasma concentrations of glutathione S-transferase.

    abstract::To assess the effect of sevoflurane anaesthesia on hepatocellular integrity, we measured plasma concentrations of glutathione S-transferase (GST) before anaesthesia and 1, 3, 6 and 24 h after the end of anaesthesia in 41 healthy, Japanese patients undergoing elective, body surface surgery. Sevoflurane (approximately 1...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/77.3.404

    authors: Ray DC,Bomont R,Mizushima A,Kugimiya T,Forbes Howie A,Beckett GJ

    更新日期:1996-09-01 00:00:00

  • Changes in intragastric pressure on induction of anaesthesia.

    abstract::Intragastric pressure was measured in 20 patients before, and immediately after, the induction of anaesthesia with thiopentone. Intragastric pressure decreased in patients whose weights were the same as or less than expected, and increased in five of seven patients whose weights were greater than expected (P = 0.0013)...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/56.8.873

    authors: Drummond GB,Park GR

    更新日期:1984-08-01 00:00:00

  • Large volume N2O uptake alone does not explain the second gas effect of N2O on sevoflurane during constant inspired ventilation.

    abstract:BACKGROUND:The second gas effect (SGE) is considered to be significant only during periods of large volume N(2)O uptake (VN(2)O); however, the SGE of small VN(2)O has not been studied. We hypothesized that the SGE of N(2)O on sevoflurane would become less pronounced when sevoflurane administration is started 60 min aft...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/ael008

    authors: Hendrickx JF,Carette R,Lemmens HJ,De Wolf AM

    更新日期:2006-03-01 00:00:00

  • A double-blind comparison between fentanyl and buprenorphrine in analgesic-supplemented anaesthesia.

    abstract::Buprenorphine 0.3 mg or fentanyl 0.125 mg i.v. were used to supplement nitrous oxide anaesthesia in a double-blind investigation of 40 patients undergoing major abdominal surgery. Initially both narcotics appeared to suppress tachycardia and increased arterial pressure in response to surgery, but 80% of the patients w...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/52.4.453

    authors: Kay B

    更新日期:1980-04-01 00:00:00

  • Improving tracheostomy care in the United Kingdom: results of a guided quality improvement programme in 20 diverse hospitals.

    abstract:BACKGROUND:Inconsistent and poorly coordinated systems of tracheostomy care commonly result in frustrations, delays, and harm. Quality improvement strategies described by exemplar hospitals of the Global Tracheostomy Collaborative have potential to mitigate such problems. This 3 yr guided implementation programme inves...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.bja.2020.04.064

    authors: McGrath BA,Wallace S,Lynch J,Bonvento B,Coe B,Owen A,Firn M,Brenner MJ,Edwards E,Finch TL,Cameron T,Narula A,Roberson DW

    更新日期:2020-07-01 00:00:00

  • Patterns of oxygenation after thoracotomy.

    abstract::We have studied patterns of oxygen saturation (SpO2) before and after thoracotomy in 20 patients monitored nightly from the preoperative night to the fourth postoperative night. After operation, 10 patients received paravertebral bupivacaine (PVB) infusion and 10 received paravertebral saline (PVS) infusion. Papaveret...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/67.6.704

    authors: Entwistle MD,Roe PG,Sapsford DJ,Berrisford RG,Jones JG

    更新日期:1991-12-01 00:00:00

  • Continuing chronic beta-blockade in the acute phase of severe sepsis and septic shock is associated with decreased mortality rates up to 90 days.

    abstract:Background:There is growing evidence that beta-blockade may reduce mortality in selected patients with sepsis. However, it is unclear if a pre-existing, chronic oral beta-blocker therapy should be continued or discontinued during the acute phase of severe sepsis and septic shock. Methods:The present secondary analysis...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aex231

    authors: Fuchs C,Wauschkuhn S,Scheer C,Vollmer M,Meissner K,Kuhn SO,Hahnenkamp K,Morelli A,Gründling M,Rehberg S

    更新日期:2017-10-01 00:00:00

  • Inhibition of mitochondrial respiration by sodium nitroprusside and the mechanism of cyanide liberation.

    abstract::The influence of sodium nitroprusside (SNP) on mitochondrial respiration was examined in rat liver mitochondria. The addition of SNP 1 mmol litre-1 during state 3 respiration inhibited the oxygen uptake by 63.4%. A mixture of SNP 1 mmol litre-1 and glutathione (GSH) 1 mmol litre-1 inhibited the oxygen uptake more mark...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/49.12.1239

    authors: Nakamura S,Shin T,Hirokata Y,Shigematsu A

    更新日期:1977-12-01 00:00:00

  • Lung function after vecuronium pretreatment in young, healthy patients.

    abstract::Lung function and clinical evidence of muscle weakness were assessed in 12 ASA I patients who received vecuronium 0.01 mg kg-1 pretreatment as a part of their anaesthetic management, before and 3 min after pretreatment. Most patients demonstrated ptosis and diplopia, while five of the 12 were unable to raise the head ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/69.3.318

    authors: Mahajan RP,Laverty J

    更新日期:1992-09-01 00:00:00

  • Use of atracurium during general surgery monitored by the train-of-four stimuli.

    abstract::The use of atracurium in 25 patients undergoing general surgical procedures is described, neuromuscular function being monitored by the "train-of-four" stimuli. An initial dose of atracurium 0.5 mg kg-1 proved to be clinically acceptable, giving good conditions for endotracheal intubation and adequate muscle relaxatio...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/54.12.1243

    authors: Hunter JM,Jones RS,Utting JE

    更新日期:1982-12-01 00:00:00

  • Expressiveness of global coagulation parameters in dilutional coagulopathy.

    abstract:BACKGROUND:Plasma-free volume replacement in haemorrhage often results in dilutional coagulopathy. Prothrombin time index (PTI) and activated partial thromboplastin time (aPTT) are used for monitoring haemostasis but have not yet been clinically evaluated. Our aim was to investigate the effects of haemodilution on the ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aeq199

    authors: Weiss G,Lison S,Spannagl M,Heindl B

    更新日期:2010-10-01 00:00:00

  • Inspired oxygen and oxygen transfer during artificial ventilation for respiratory failure.

    abstract::Arterial oxygenation was measured in patients being ventilated artificially for respiratory failure, initially at the FIO2 that had been selected clinically to achieve PaO2 at least normal, and then at each of two or three progressively increased FIO2 values up to about 0.9. Impairment of oxygen transfer was assessed ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/55.1.3

    authors: Drummond GB,Zhong NS

    更新日期:1983-01-01 00:00:00

  • Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison.

    abstract:BACKGROUND:We used an automated bispectral index (BIS)-guided dual-loop controller to determine propofol and remifentanil requirements during general anaesthesia in obese and lean surgical patients. METHODS:Obese patients, BMI>35 kg m(-2), and lean patients (<25 kg m(-2)) having laparoscopic procedures were prospectiv...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1093/bja/aeu401

    authors: Liu N,Lory C,Assenzo V,Cocard V,Chazot T,Le Guen M,Sessler DI,Journois D,Fischler M

    更新日期:2015-04-01 00:00:00

  • Improved performance on cardiopulmonary exercise testing following DDDR pacemaker adjustment: a case report.

    abstract::We report a case of improved cardiopulmonary exercise (CPX) test outcomes measured 48 h after initial CPX testing and immediately after alterations were made to the settings of a dual chamber, dual sensing pacemaker with exercise detection. The changes allowed successful abdominal surgery to be completed. ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aet587

    authors: Bolsin S,Colson M,Ridley D,Ward C

    更新日期:2014-06-01 00:00:00

  • Total i.v. anaesthesia with propofol and alfentanil: dose requirements for propofol and the effect of premedication with clonidine.

    abstract::We determined in 51 healthy patients undergoing body surface surgery the dose requirements for propofol, as part of a total i.v. anaesthesia technique with an alfentanil infusion. After premedication with temazepam, patients received alfentanil 50 micrograms kg-1 followed by an infusion of 50 micrograms kg-1 h-1. Pati...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1093/bja/65.2.157

    authors: Richards MJ,Skues MA,Jarvis AP,Prys-Roberts C

    更新日期:1990-08-01 00:00:00

  • Arterial pressure management and carotid endarterectomy.

    abstract::Acute perioperative changes in arterial pressure occur frequently, particularly in patients with cardiovascular disease or those receiving vasoactive medications, or in relation to certain cardiovascular surgical procedures. Both hypo- and hypertension are common in patients undergoing carotid surgery because of uniqu...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/aep012

    authors: Stoneham MD,Thompson JP

    更新日期:2009-04-01 00:00:00

  • Infusion thrombophlebitis.

    abstract::Infusion thrombophlebitis is a common complication of i.v. infusions. Many factors appear to be involved in its aetiology, of which the duration of infusion, the drugs infused and the solution(s) infused are the most important. Effective prophylaxis should be based on an understanding of the possible pathophysiology. ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/57.2.220

    authors: Lewis GB,Hecker JF

    更新日期:1985-02-01 00:00:00

  • Experience with spinal analgesia in a British obstetric unit.

    abstract::A series of 443 spinal anaesthetics is described. The procedures included operative vaginal delivery, removal of retained placenta and a miscellaneous group common to most obstetric units. Failure to provide effective relief of pain occurred in 5.2% of patients. There was one potentially serious complication, but with...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/51.6.531

    authors: Crawford JS

    更新日期:1979-06-01 00:00:00

  • Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity.

    abstract::The study of rare families with inherited pain insensitivity can identify new human-validated analgesic drug targets. Here, a 66-yr-old female presented with nil requirement for postoperative analgesia after a normally painful orthopaedic hand surgery (trapeziectomy). Further investigations revealed a lifelong history...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1016/j.bja.2019.02.019

    authors: Habib AM,Okorokov AL,Hill MN,Bras JT,Lee MC,Li S,Gossage SJ,van Drimmelen M,Morena M,Houlden H,Ramirez JD,Bennett DLH,Srivastava D,Cox JJ

    更新日期:2019-08-01 00:00:00

  • Comparison of thiopentone, Althesin and ketamine in anaesthesia for otolaryngological surgery in children.

    abstract::Thiopentone 4 mg/kg, Althesin 0.055 ml/kg and ketamine 2 mg/kg were compared in 157 children undergoing minor otolaryngological surgery, mostly adenotonsillectomy. Premedication was with pethidine and atropine and anaesthesia was maintained with nitrous oxide in oxygen and halothane. Tracheal intubation was facilitate...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1093/bja/49.4.363

    authors: Saarnivaara L

    更新日期:1977-04-01 00:00:00

  • Effect of clonidine on gastric emptying of liquids.

    abstract::We have investigated the effects of clonidine on gastric emptying of liquids in 30 patients. In a double-blind, randomized design, clonidine 150 micrograms, morphine 10 mg or saline in 1 ml was given i.m. One hour later, the patient drank a paracetamol solution (1.5 g in 50 ml water). Venous blood samples were obtaine...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/78.1.28

    authors: Asai T,McBeth C,Stewart JI,Williams J,Vaughan RS,Power I

    更新日期:1997-01-01 00:00:00

  • Effect of changes in arterial-mixed venous oxygen content difference (C(a-v)O2) on indices of pulmonary oxygen transfer in a model ARDS lung.

    abstract::Many indices are used to quantify pulmonary oxygen transfer. Indices that use only measurements from arterial blood and inspired gas assume a constant C(a-v)O2. Though variations in C(a-v)O2 are recognized, indices such as PaO2/FIO2 remain popular and are often considered the best measure of pulmonary oxygen transfer ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/86.4.477

    authors: Nirmalan M,Willard T,Columb MO,Nightingale P

    更新日期:2001-04-01 00:00:00

  • Comparison of two ultrasound guided approaches for axillary vein catheterization: a randomized controlled non-inferiority trial.

    abstract:BACKGROUND:Axillary vein catheterization via a distal approach is an alternative to the proximal approach to axillary/subclavian vein catheterization under ultrasound (US) guidance. The aim of this trial was to compare the two approaches. METHODS:In a randomized single-centre study, all patients requiring central vein...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aev458

    authors: Buzançais G,Roger C,Bastide S,Jeannes P,Lefrant JY,Muller L

    更新日期:2016-02-01 00:00:00