Comparison of thiopentone, Althesin and ketamine in anaesthesia for otolaryngological surgery in children.

Abstract:

:Thiopentone 4 mg/kg, Althesin 0.055 ml/kg and ketamine 2 mg/kg were compared in 157 children undergoing minor otolaryngological surgery, mostly adenotonsillectomy. Premedication was with pethidine and atropine and anaesthesia was maintained with nitrous oxide in oxygen and halothane. Tracheal intubation was facilitated with suxamethonium. In each group half of the children received pethidine 0.7 mg/kg after intubation and the remainder received saline. Ketamine increased arterial pressure after induction. The cardiovascular responses to intubation were more obvious after thiopentone and Althesin than after ketamine. Operating conditions, cardiovascular changes during operation and the course of extubation were similar in all groups. The recovery after ketamine was longer than after thiopentone and Althesin. Thiopentone was associated with significantly less vomiting immediately after operation than was Althesin and ketamine. In the period immediately after operation Althesin was associated with a higher need for analgesics compared with thiopentone and ketamine. Pethidine prolonged the recovery after thiopentone, decreased the incidence of vomiting immediately after operation associated with Althesin and increased that associated with ketamine.

journal_name

Br J Anaesth

authors

Saarnivaara L

doi

10.1093/bja/49.4.363

subject

Has Abstract

pub_date

1977-04-01 00:00:00

pages

363-70

issue

4

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)53257-2

journal_volume

49

pub_type

临床试验,杂志文章
  • Dangers of anaesthesia in Munchausen's syndrome.

    abstract::Patients with Munchausen's syndrome often undergo multiple surgical operations under general anaesthesia. They tend to have multiple exposures to routinely used anaesthetic agents. A patient with Munchausen's syndrome who developed an anaphylactoid reaction to thiopentone is described and the importance of obtaining p...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/59.11.1472

    authors: Frater RA,Lew JK

    更新日期:1987-11-01 00:00:00

  • Solvent for etomidate may cause pain and adverse effects.

    abstract::We tested the hypothesis that the solvent for etomidate was a factor in the incidence of pain and other side effects after injection, and that these were associated with histamine release. Nine of 10 volunteers who received etomidate in a propylene glycol formulation reported moderate to severe pain on injection; only...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/83.3.464

    authors: Doenicke AW,Roizen MF,Hoernecke R,Lorenz W,Ostwald P

    更新日期:1999-09-01 00:00:00

  • Determinants of outcome in critically ill octogenarians after surgery: an observational study.

    abstract:BACKGROUND:The population in the UK is growing older and the number of elderly patients cared for on intensive care units (ICU) is increasing. This study was designed to identify risk factors for mortality in critically ill patients of >80 yr of age after surgery. METHODS:We identified 275 patients, aged 80 yr or grea...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aem307

    authors: Ford PN,Thomas I,Cook TM,Whitley E,Peden CJ

    更新日期:2007-12-01 00:00:00

  • A sheep preparation for studying interactions between blood flow and drug disposition. IV: The effects of general and spinal anaesthesia on blood flow and cefoxitin disposition.

    abstract::Control measurements of blood flow through and cefoxitin extraction ratios across heart and lungs, liver, kidneys and gut were made under steady-state conditions in awake unrestrained sheep. The studies then were repeated with the same animals anaesthetized with 1.5% halothane or whilst undergoing high thoracic (to ap...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/57.12.1239

    authors: Runciman WB,Mather LE,Ilsley AH,Carapetis RJ,Upton RN

    更新日期:1985-12-01 00:00:00

  • Inhibition of mitochondrial respiration by sodium nitroprusside and the mechanism of cyanide liberation.

    abstract::The influence of sodium nitroprusside (SNP) on mitochondrial respiration was examined in rat liver mitochondria. The addition of SNP 1 mmol litre-1 during state 3 respiration inhibited the oxygen uptake by 63.4%. A mixture of SNP 1 mmol litre-1 and glutathione (GSH) 1 mmol litre-1 inhibited the oxygen uptake more mark...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/49.12.1239

    authors: Nakamura S,Shin T,Hirokata Y,Shigematsu A

    更新日期:1977-12-01 00:00:00

  • Unconscious auditory priming during surgery with propofol and nitrous oxide anaesthesia: a replication.

    abstract:BACKGROUND:Priming during anaesthesia has been hard to replicate and the conditions under which it occurs remain poorly understood. We replicated and extended a recent study to determine whether intraoperative priming during propofol and nitrous oxide anaesthesia is a reliable phenomenon, whether it occurs due to aware...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/aeh289

    authors: Deeprose C,Andrade J,Harrison D,Edwards N

    更新日期:2005-01-01 00:00:00

  • End-tidal carbon dioxide concentration as an indicator of pulmonary blood flow during closed heart surgery in children. A report of two cases.

    abstract::The value of the continuous monitoring of end-tidal carbon dioxide concentration as an indicator of the acute intraoperative interruption of pulmonary blood flow, in patients with pre-existing restrictions of pulmonary blood flow undergoing closed heart surgery, is illustrated by two case reports. Decreases in end-tid...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/57.12.1257

    authors: Schuller JL,Bovill JG,Nijveld A

    更新日期:1985-12-01 00:00:00

  • Morphological and biochemical defects in muscles of human carriers of the malignant hyperthermia syndrome.

    abstract::This communication presents evidence in support of a neuropathic basis for the myopathy associated with malignant hyperpyrexia (MH). Muscle from MH susceptible individuals showed a reduced calcium uptake by the sarcoplasmic reticulum. There was a reduced concentration of phosphocreatine and ATP and an increased concen...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/47.4.475

    authors: Isaacs H,Heffron JJ

    更新日期:1975-04-01 00:00:00

  • Animal studies of the anaesthetic activity of ICI 35 868.

    abstract::The activity of a new i.v. anesthetic agent ICI 35 868, a compound unrelated to currently used barbiturate, eugenol or steroid agents, has been examined in a range of animal species. Some of the properties of ICI 35 868 resemble those of thiopentone in that it is a rapidly acting agent which produces anaesthesia of sh...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/52.8.731

    authors: Glen JB

    更新日期:1980-08-01 00:00:00

  • Preoxygenation--the importance of a good face mask seal.

    abstract::We have studied 16 healthy volunteers whose lungs were preoxygenated six times each in order to assess the amount of room air entrained during tidal volume preoxygenation if a good seal is not maintained between the face mask and the face. With a fresh gas flow of 10 litre min-1, we found that using gravity alone to h...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1093/bja/75.6.777

    authors: McGowan P,Skinner A

    更新日期:1995-12-01 00:00:00

  • Xenon decreases cell migration and secretion of a pro-angiogenesis factor in breast adenocarcinoma cells: comparison with sevoflurane.

    abstract:BACKGROUND:While volatile agents have been implicated in metastasis-enhancing effects on cancer cells, the effects of xenon are unknown. We investigated xenon- and sevoflurane-mediated effects on migration and expression of angiogenesis biomarkers in human breast adenocarcinoma cells. METHODS:MDA-MB-231 and MCF-7 cell...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aeu191

    authors: Ash SA,Valchev GI,Looney M,Ni Mhathuna A,Crowley PD,Gallagher HC,Buggy DJ

    更新日期:2014-07-01 00:00:00

  • Spinal anaesthesia for paediatric day-case surgery: a double-blind, randomized, parallel group, prospective comparison of isobaric and hyperbaric bupivacaine.

    abstract::We have compared bupivacaine 5 mg ml-1, either isobaric in saline 0.9% or hyperbaric in 8% glucose, for spinal anaesthesia in 100 children, aged 2-115 months, in a double-blind, randomized, parallel group, prospective study. Children were premedicated with diazepam 0.5 mg kg-1 orally. Seventy-two children were sedated...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/81.4.502

    authors: Kokki H,Tuovinen K,Hendolin H

    更新日期:1998-10-01 00:00:00

  • Blockade of contralateral carotid sinus nerve enhances ipsilateral nerve action potentials under halothane anaesthesia.

    abstract::In 10 dogs, one carotid sinus was isolated from the systemic circulation without disturbing its sympathetic innervation. The isolated sinus was connected to a servo-controlled pressure generator which kept mean intrasinus pressure, pulse pressure, and frequency of pulsation constant. The carotid sinus baroreceptor ner...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/59.4.489

    authors: Behnia R,Koushanpour E,Shanks CA,McCarthy WJ

    更新日期:1987-04-01 00:00:00

  • Comparison of flumazenil with aminophylline to antagonize midazolam in elderly patients.

    abstract::We have compared, in a double-blind study, the efficacy of flumazenil with that of aminophylline in antagonizing the effects of midazolam in 60 patients (ASA I-II, mean age 66 yr) undergoing transurethral resection of prostate under spinal anaesthesia. All patients received midazolam 0.075 mg kg-1 i.v. and the test dr...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/66.5.591

    authors: Sibai AN,Sibai AM,Baraka A

    更新日期:1991-05-01 00:00:00

  • Heat and moisture exchangers in artificial ventilation. An experimental study of the effect of gas leakage.

    abstract::The effect of gas leakage around an uncuffed tracheal tube on the performance of Heat and Moisture Exchangers (HME) was examined experimentally. Such leaks were shown to cause measurable decreases in the humidity output and efficiency of HME. The magnitude of the decrease in humidity output was shown to be dependent u...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/59.9.1181

    authors: Tilling SE,Hayes B

    更新日期:1987-09-01 00:00:00

  • Electrical impedance tomography to confirm correct placement of double-lumen tube: a feasibility study.

    abstract:BACKGROUND:Double-lumen tubes (DLTs) are frequently used to establish one-lung ventilation (OLV). Their correct placement is crucial. We hypothesized that electrical impedance tomography (EIT) reliably displays distribution of ventilation between left and right lung and may thus be used to verify correct DLT placement ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aen166

    authors: Steinmann D,Stahl CA,Minner J,Schumann S,Loop T,Kirschbaum A,Priebe HJ,Guttmann J

    更新日期:2008-09-01 00:00:00

  • Retraction notice to "Volume replacement in the surgical patient--does the type of solution make a difference?" [Br J Anaesth 84 (2000) 783-93].

    abstract::This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief, Professor Hugh Hemmings, based on the recommendations of Justus-Liebig-University Giessen f...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,撤回出版物

    doi:10.1016/j.bja.2020.07.036

    authors: Boldt J

    更新日期:2020-09-01 00:00:00

  • Incidence of venous gas embolism during robotic-assisted laparoscopic radical prostatectomy is lower than that during radical retropubic prostatectomy.

    abstract:BACKGROUND:Robotic-assisted laparoscopic radical prostatectomy (RALRP) is gaining popularity as a less traumatic and minimally invasive alternative to open radical retropubic prostatectomy (RRP). The aim of this study was to evaluate the incidence and grade of venous gas embolism (VGE) during RALRP compared with those ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aeq247

    authors: Hong JY,Kim JY,Choi YD,Rha KH,Yoon SJ,Kil HK

    更新日期:2010-12-01 00:00:00

  • Association of weaning failure from mechanical ventilation with transthoracic echocardiography parameters: a systematic review and meta-analysis.

    abstract:BACKGROUND:Weaning from mechanical ventilation is a challenging step during recovery from critical illness. Weaning failure or early reintubation are associated with increased morbidity and mortality, exposing patients to life-threatening complications. Cardiac dysfunction represents the most common cause of weaning fa...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.bja.2020.07.059

    authors: Sanfilippo F,Di Falco D,Noto A,Santonocito C,Morelli A,Bignami E,Scolletta S,Vieillard-Baron A,Astuto M

    更新日期:2021-01-01 00:00:00

  • Fire and explosion hazards in operating theatres.

    abstract::A high degree of safety from fires and explosions exists in operating theatres in the U.K. and this is reflected in the extremely low number of fatal and non-fatal accidents which occur. This has been achieved by safety precautions which in some respects have been over-careful and overexpensive. Antistatic precautions...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/50.7.659

    authors: Vickers MD

    更新日期:1978-07-01 00:00:00

  • A consensus checklist to help clinicians interpret clinical trial results analysed by Bayesian methods.

    abstract:INTRODUCTION:In the context of an increasing number of publications of trial data analysed by Bayesian methods, clinicians need support to better understand Bayesian statistical methods. The existing checklists are intended for people who already know these methods. We aimed to establish and validate a checklist that c...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1016/j.bja.2020.04.093

    authors: Ferreira D,Barthoulot M,Pottecher J,Torp KD,Diemunsch P,Meyer N

    更新日期:2020-08-01 00:00:00

  • Is thoracic ultrasound a viable alternative to conventional imaging in the critical care setting?

    abstract::Thoracic imaging is regularly performed on the majority of critical care patients. Conventionally, this uses a combination of plain radiography and computed tomography. There is growing enthusiasm for the use of ultrasound to replace much of this radiology and provide more immediate, point-of-care imaging with reducti...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/aet076

    authors: Ashton-Cleary DT

    更新日期:2013-08-01 00:00:00

  • Drawover anaesthesia and preoxygenation.

    abstract::We have studied the efficacy of preoxygenation using the Triservice Anaesthetic Apparatus (TSA) in healthy patients and found it to be unsatisfactory. An alternative technique suitable for field use was explored. The Mapleson D system (Bain) was found to be suitable for preoxygenation with a fresh gas flow of only 4 l...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/66.2.196

    authors: Lowe DM,McFadzean W

    更新日期:1991-02-01 00:00:00

  • Molecular weight of hydroxyethyl starch: is there an effect on blood coagulation and pharmacokinetics?

    abstract:BACKGROUND:The development of hydroxyethyl starches (HES) with low impact on blood coagulation but higher volume effect compared with the currently used HES solutions is of clinical interest. We hypothesized that high molecular weight, low-substituted HES might possess these properties. METHODS:Thirty pigs were infuse...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aei108

    authors: Madjdpour C,Dettori N,Frascarolo P,Burki M,Boll M,Fisch A,Bombeli T,Spahn DR

    更新日期:2005-05-01 00:00:00

  • Studies on dimethyl tubocurarine in anaesthetized man.

    abstract::Intravenous doses of 0.3 mg/kg dimethyl tubocurarine were required for consistent and adequate surgical relaxation in patients during nitrous oxide anaesthesia and produced virtually complete neuromuscular paralysis (96-100%) of the tetanic and twitch responses of the adductor pollicis muscle. The duration of action o...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1093/bja/48.10.969

    authors: Hughes R,Ingram GS,Payne JP

    更新日期:1976-10-01 00:00:00

  • Induction dose-response of propofol in unpremedicated children.

    abstract::The induction dose requirements of propofol were compared in three age groups in 300 unpremedicated healthy Chinese children: group A, younger than 2 yr (n = 48); group B, 2-5 yr (n = 117); group C, 6-12 yr (n = 135). Patients in each group were allocated randomly to receive one of eight doses of propofol (1.2, 1.4, 1...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/68.1.64

    authors: Aun CS,Short SM,Leung DH,Oh TE

    更新日期:1992-01-01 00:00:00

  • Balancing paediatric anaesthesia: preclinical insights into analgesia, hypnosis, neuroprotection, and neurotoxicity.

    abstract::Logistical and ethical reasons make conducting clinical research in paediatric practice difficult, and therefore safe and efficacious advances are dependent on good preclinical research. For example, notable advances have been made in preclinical studies of pain processing that correlate well with patient data. Other ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/aen263

    authors: Sanders RD,Ma D,Brooks P,Maze M

    更新日期:2008-11-01 00:00:00

  • ACE inhibitor premedication attenuates sympathetic responses during surgery.

    abstract::We studied cardiovascular and catecholamine responses for 3 days in three groups of patients undergoing abdominal hysterectomy. The night before surgery and again 2 h before induction of anaesthesia, patients received the ACE inhibitor, ramipril, the beta 1 blocker, metoprolol, or placebo. In the actively treated grou...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/72.6.633

    authors: Böttcher M,Behrens JK,Møller EA,Christensen JH,Andreasen F

    更新日期:1994-06-01 00:00:00

  • Relationship of perioperative anaphylaxis to neuromuscular blocking agents, obesity, and pholcodine consumption: a case-control study.

    abstract:BACKGROUND:The observation that patients presenting for bariatric surgery had a high incidence of neuromuscular blocking agent (NMBA) anaphylaxis prompted this restricted case-control study to test the hypothesis that obesity is a risk factor for NMBA anaphylaxis, independent of differences in pholcodine consumption. ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1016/j.bja.2020.12.018

    authors: Sadleir PHM,Clarke RC,Goddard CE,Day C,Weightman W,Middleditch A,Platt PR

    更新日期:2021-01-13 00:00:00

  • Effect of volatile anaesthetics on cell survival as measured by colony forming ability.

    abstract::Chinese hamster fibroblast cells in stirred suspension cultures were exposed to volatile anaesthetic agents for 3 hr or for 24 hr. Cell viability was measured as colony forming ability and was found to be reduced, in a dose related manner, by halothane, chloroform, methoxyflurane, trichloroetheylene and diethyl ether....

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/47.8.831

    authors: Sturrock JE

    更新日期:1975-08-01 00:00:00