Induction dose-response of propofol in unpremedicated children.

Abstract:

:The induction dose requirements of propofol were compared in three age groups in 300 unpremedicated healthy Chinese children: group A, younger than 2 yr (n = 48); group B, 2-5 yr (n = 117); group C, 6-12 yr (n = 135). Patients in each group were allocated randomly to receive one of eight doses of propofol (1.2, 1.4, 1.6, 1.8, 2.0, 2.2, 2.4 and 2.6 mg kg-1). ED50 and ED95 for loss of eyelash reflex (LER) and acceptance of face mask (AFM) were determined using probit analysis. ED50 and ED95 for both LER and AFM were greatest in group A, less in B and smallest in C; ED95 (AFM) for groups A, B and C were 2.88 (2.55-3.36), 2.53 (2.31-2.86), and 2.20 (2.02-2.46) mg kg-1, respectively. This probably represented their effective induction dose. The incidence of apnoea was dose related, but not pain on injection.

journal_name

Br J Anaesth

authors

Aun CS,Short SM,Leung DH,Oh TE

doi

10.1093/bja/68.1.64

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

64-7

issue

1

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)46782-1

journal_volume

68

pub_type

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