A measure of consciousness and memory during isoflurane administration: the coherent frequency.

Abstract:

:The coherent frequency (CF) of the auditory evoked response (AER) is derived using auditory clicks presented at frequencies in the range 5-47 Hz. CF and psychological performance were measured while seven subjects breathed isoflurane in doses increasing from 0% to 0.2%, 0.4% and 0.8% end-tidal concentration and then decreasing to 0%. With increasing doses of isoflurane, CF decreased and there was a decrease in within-list recognition (WLR) and category recognition (CR) scores. There was a correlation between changes in CF and WLR (P < 0.05) and between CF and category recognition (CR) (P < 0.05). A painful stimulus given in conjunction with 0.4% isoflurane caused an increase in CF, WLR and CR in some subjects. This did not reach statistical significance for the group as a whole, apart from the short word interval scores in the WLR which indicated an increase in attention (P < 0.01). Subjects did not respond with 0.8% isoflurane, either before or after painful stimulation. Reduction of end-tidal isoflurane from 0.8% to 0% caused an increase in the CF and improved performance on the psychological tests. A category generation task on recovery showed no evidence of implicit learning of words presented in conjunction with 0.8% isoflurane.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Br J Anaesth

authors

Munglani R,Andrade J,Sapsford DJ,Baddeley A,Jones JG

doi

10.1093/bja/71.5.633

subject

Has Abstract

pub_date

1993-11-01 00:00:00

pages

633-41

issue

5

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)44670-8

journal_volume

71

pub_type

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