A possible means of rapid cooling in the emergency treatment of malignant hyperpyrexia.

Abstract:

:A possible means of rapid cooling in the emergency treatment of malignant hyperpyrexia, peritoneal dialysis using a cold dialysate, is described. Experimental observations in a young man on a regular peritoneal dialysis regime showed that significant heat extraction can be obtained when either a cool (20 degrees C) or cold (9 degrees C) dialysis fluid is used. The maximum heat exchange observed was 17.5 kJ/min when 2 litre of cold dialysis was instilled for a mean time of 10 min. This rate of heat exchange is within the 10--40 kJ/min range of excess heat production that occurs in malignant hyperpyrexia. Since peritoneal dialysis is, technically, a very quick and simple procedure, it is suggested that it might play a very useful role in the emergency treatment of malignant hyperpyrexia. The dialysis treatment would also correct some of the biochemical disturbances that occur in this condition.

journal_name

Br J Anaesth

authors

Gjessing J,Barsa J,Tomlin PJ

doi

10.1093/bja/48.5.469

subject

Has Abstract

pub_date

1976-05-01 00:00:00

pages

469-73

issue

5

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)48694-6

journal_volume

48

pub_type

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