Abstract:
BACKGROUND:Low-dose droperidol is suggested to be cost-effective in preventing nausea and vomiting after ambulatory surgery. This clinical study evaluated patient postural stability using a computerized force platform after an i.v. dose of droperidol 0.625 mg in outpatients undergoing gynaecological dilatation and curettage procedures. METHODS:After institutional approval and informed consent, 120 females were randomly assigned to receive either 0.9% saline (placebo) or droperidol 0.625 mg i.v. before surgery. Anaesthesia was induced with propofol 2-2.5 mg kg-1 and fentanyl 50-100 micrograms, and was maintained with intermittent boluses of propofol 25-50 mg and fentanyl 25-50 micrograms i.v. After operation, the Post-Anaesthesia Discharge Score (PADS), patient self-assessment scores for pain, nausea, drowsiness and dizziness, and extrapyramidal symptoms were recorded. Body sway velocity was measured while the patient was standing on a firm surface with eyes open then closed vs standing on a foam surface with eyes open then closed, at the time of arrival in the operation holding area (baseline), on achieving a PADS of 9 after surgery and on discharge home. RESULTS:At the time of achieving a PADS of 9, body sway was significantly greater in the droperidol group than in the placebo group (overall 61% vs 33% above baseline). There were no differences between groups with respect to scores for pain, nausea, drowsiness and dizziness. Three patients (5%) in the droperidol group reported nervousness and restlessness postoperatively (not significant). CONCLUSION:Low-dose droperidol 0.625 mg i.v. for anti-emetic prophylaxis can cause balance disturbances in females after gynaecological dilatation and curettage procedures.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Song D,Chung F,Yogendran S,Wong Jdoi
10.1093/bja/88.6.819subject
Has Abstractpub_date
2002-06-01 00:00:00pages
819-23issue
6eissn
0007-0912issn
1471-6771pii
S0007-0912(17)37141-6journal_volume
88pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:Pulse pressure variation (PPV) and stroke volume variation (SVV) are robust indicators of fluid responsiveness in mechanically ventilated supine patients. The aim of the study was to evaluate the ability of PPV and SVV to predict fluid responsiveness in mechanically ventilated patients in the prone position ...
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