Abstract：
:The plasma decay of atracurium besylate was examined in two groups of six patients. Group I received atracurium 0.6 mg kg-1 and group II 0.3 mg kg-1 as a single bolus dose i.v. The plasma concentrations were measured by high performance liquid chromatography. An individual two-compartment pharmacokinetic model was used for interpretation. The results from the two groups were not significantly different, giving overall mean values of 2 min (+/- 0.2 SEM) for the distribution half-life (T1/2 alpha), 19.9 min (+/- 0.6) for the elimination half-life (T1/2 beta), 5.5 ml min-1 kg-1 (+/- 0.2) for total clearance (Cl) and 157 ml kg-1 (+/- 7) for total distribution volume (Varea).
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Ward S,Neill EA,Weatherley BC,Corall IMdoi
10.1093/bja/55.2.113subject
Has Abstractpub_date
1983-02-01 00:00:00pages
113-8issue
2eissn
0007-0912issn
1471-6771pii
S0007-0912(17)42634-1journal_volume
55pub_type
杂志文章abstract：:The anaesthetist's work, aimed at giving safe anaesthesia to patients, can do both harm and good to the anaesthetist. Research on stress in anaesthesia has traditionally focused on how the negative effects of stress can be avoided and much effort has been put into improving anaesthetists' work environment to reduce th...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1093/bja/aeq125
更新日期：2010-07-01 00:00:00
abstract：:In 40 patients anaesthetized with thiopentone, 66% nitrous oxide and 1% halothane, the effects of a single i.v. dose of nalbuphine 4.5, 8, 15, 25 or 50 mg/70 kg or morphine 3, 5, 10 or 17.5 mg/70 kg on total ventilation and end-tidal carbon dioxide concentration have been measured. Depression of respiration occurred w...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/58.6.625
更新日期：1986-06-01 00:00:00
abstract：:We describe the management of three patients undergoing awake carotid surgery who developed signs of cerebral ischaemia after carotid cross-clamping. Drug treatment to increase arterial blood pressure above baseline reversed the neurological deficit and an internal carotid artery shunt was not needed. Shunt insertion ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/87.4.641
更新日期：2001-10-01 00:00:00
abstract：:The Walton-Brodie strain gauge arch is an instrument that quantitatively measures CF. Like many methods, the strain gauge arch is affected by loading conditions and heart rate. Nevertheless, this methodology, when properly used, has proved very useful in describing the direct action of anaesthetic drugs. Knowledge fro...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1093/bja/60.suppl_1.78s
更新日期：1988-01-01 00:00:00
abstract：:Before the induction of labour in 34 pregnant women 1.5% lignocaine 10 ml was injected into the lumbar extradural space at constant rates between 0.143 and 0.333 ml s-1. Injection pressures and residual pressures were recorded and the extent of analgesia to pinprick was assessed. No significant correlation was found b...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/52.1.55
更新日期：1980-01-01 00:00:00
abstract：:We present an unusual case of hypercapnia and surgical emphysema during transanal endoscopic microsurgery, which led to delayed post-operative ventilatory failure. The hypercapnia and surgical emphysema were secondary to rectal insufflation with carbon dioxide used to facilitate visualization and resection of a rectal...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/86.4.586
更新日期：2001-04-01 00:00:00
abstract：:Artery-to-muscle (A-M) onset time for five neuromuscular blocking agents was studied in 50 female patients under light endotracheal anaesthesia. Circulation to the right arm was occluded by a tourniquet and released 1 min after the injection i.v. into the left arm of a myoneural blocking drug. Muscle twitches were rec...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/52.4.403
更新日期：1980-04-01 00:00:00
abstract：:The haemodynamic responses to isovolumic anaemia (dextran-for-blood exchange) were studied in seven dogs pretreated with propranolol 20 mg/kg body weight for 3 weeks. Adrenergic beta-receptor blockade did not prevent significant increases in heart rate (up to 19%). Cardiac output increased by about 20% while systemic ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：
更新日期：1980-03-01 00:00:00
abstract：:Profound postoperative respiratory depression after larger doses of fentanyl was partially reversed by 4-aminopyridine. This reversal was independent of FIO2' suggesting that the response was not dependent upon peripheral chemoreceptor-mediated drive. Similar reversal of fentanyl-induced depression by 4-aminopyridine ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/53.4.373
更新日期：1981-04-01 00:00:00
abstract：:The effect of diluting propofol in 5% dextrose on the incidence of i.v. injection pain was studied in 100 adult patients. Severe injection pain occurred in 32% (16 patients) who received undiluted propofol, compared with 10% (five patients) who received dilute propofol. We concluded that the dilution of propofol signi...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/62.2.202
更新日期：1989-02-01 00:00:00
abstract：:Seventy-two adult surgical patients were studied to compare neuromuscular and cardiovascular effects of mivacurium chloride during nitrous oxide-fentanyl-thiopentone (BAL group) or nitrous oxide-halothane (HAL group) anaesthesia. Eighteen patients in the BAL group received an initial bolus of mivacurium, either the ED...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章
doi：10.1093/bja/64.2.193
更新日期：1990-02-01 00:00:00
abstract：BACKGROUND:Cut-off points (CPs) of the numeric rating scale (NRS 0-10) are regularly used in postoperative pain treatment. However, there is insufficient evidence to identify the optimal CP between mild and moderate pain. METHODS:A total of 435 patients undergoing general, trauma, or oral and maxillofacial surgery wer...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aer195
更新日期：2011-10-01 00:00:00
abstract：:We report the extradural administration of low-dose morphine in 10 ml of 10% dextrose (2-3 mg) to 98 adult patients with various types of acute and chronic pain. Extradural morphine injections were given either via a Tuohy needle (single or repeat injection) or via an extradural catheter. Pain relief was evaluated by ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/52.3.247
更新日期：1980-03-01 00:00:00
abstract：:We have studied the effect of P6 acupuncture on postoperative vomiting in 45 children undergoing tonsillectomy. After induction of anaesthesia and before the start of surgery, 50% of the patients received P6 acupuncture (in the middle of the ventral surface of the wrist) for 5 min. There was no difference in the incid...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/67.6.779
更新日期：1991-12-01 00:00:00
abstract：:In this report we present the case of a 77-yr-old man who underwent resection of the upper lobe of the left lung for a carcinoma, six weeks after percutaneous transluminal coronary angioplasty (PTCA) with stenting of the left anterior descending (LAD) and circumflex coronary arteries. Antiplatelet therapy with clopido...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aeh110
更新日期：2004-05-01 00:00:00
abstract：BACKGROUND:Interscalene brachial plexus block (ISBPB) is an effective nerve block for shoulder surgery. However, a 100% incidence of phrenic nerve palsy limits the application of ISBPB for patients with limited pulmonary reserve. We examined the incidence of phrenic nerve palsy with a low-volume ISBPB compared with a s...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aen229
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND:The low and moderate doses of dexmedetomidine reduce arterial pressure and heart rate (HR), suggesting attenuation of sympathetic activity and dominance of cardiac-vagal activity. These autonomic responses under dexmedetomidine sedation may attenuate cardiovascular reflex responses to temporal reduction in a...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aep210
更新日期：2009-10-01 00:00:00
abstract：:The rapid detection and evaluation of patients presenting with perioperative neurological dysfunction is of great clinical relevance. Biomarkers have been defined as biological molecules that can be used as an indicator of new onset or progression of a biological process or effect of treatment. Biomarkers have become ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1093/bja/aer338
更新日期：2011-12-01 00:00:00
abstract：:One hundred and forty male rats received a cryoinjury to a segment of the exposed sciatic nerve. A variety of temperatures and freeze patterns was used and the recovery of function was monitored. Where obvious nerve freezing occurred, the cryoinjury caused complete loss of function in the limb. The return of motor act...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/53.11.1121
更新日期：1981-11-01 00:00:00
abstract：BACKGROUND:General anaesthesia is a balance between hypnosis and analgesia. We investigated whether an increase in remifentanil blood concentration would reduce the amount of propofol required to maintain a comparable level of anaesthesia in 60 patients undergoing ambulatory surgery. METHODS:Patients were allocated ra...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/aeg115
更新日期：2003-05-01 00:00:00
abstract：Background.:Perioperative administration of cefazolin reduces the incidence of perioperative infections. Intraoperative re-dosing of cefazolin is commonly given between 2 and 5 h after the initial dose. This study was undertaken to determine whether intraoperative continuous infusions of cefazolin achieve better probab...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aex026
更新日期：2017-06-01 00:00:00
abstract：:The sedation of 50 children aged 6 months to 9 years who had undergone open heart surgery was studied. During artificial ventilation a midazolam infusion was used in conjunction with the administration of morphine (and tubocurarine). Sedation for patients breathing spontaneously with positive airway pressure was conti...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/58.10.1104
更新日期：1986-10-01 00:00:00
abstract：BACKGROUND:The safety of performing spinal anaesthesia for both patients and anaesthetists alike in the presence of active infection with the novel coronavirus disease 2019 (COVID-19) is unclear. Here, we report the clinical characteristics and outcomes for both patients with COVID-19 and the anaesthetists who provided...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2020.03.007
更新日期：2020-06-01 00:00:00
abstract：:Diaphragm strength can be assessed from twitch gastric (TwPgas), twitch oesophageal (TwPoes), and twitch transdiaphragmatic pressure (TwPdi) in response to phrenic nerve stimulation. This requires the passage of balloon catheters, which may be difficult. Changes in pressure measured at the mouth during phrenic nerve s...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/87.6.876
更新日期：2001-12-01 00:00:00
abstract：:Gas injection systems used in several techniques of ventilation cause increases in airway pressure and physiological changes which are frequently overlooked. The momentum flux theory describes such phenomena most appropriately. We have defined and measured the characteristics of such increases in airway pressure, usin...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/63.7.71
更新日期：1989-01-01 00:00:00
abstract：:We have measured the partial pressure of isoflurane simultaneously in inspired gas (PIiso), end-expired gas (PE'iso), mixed-expired gas (PEiso), arterial (Paiso) and mixed venous blood (Pviso) in six patients (aged 57-79 yr) anaesthetized with nitrous oxide, oxygen and isoflurane before surgery and after PE'iso had be...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/70.6.605
更新日期：1993-06-01 00:00:00
abstract：:We studied the elimination rate of nitrous oxide in 36 patients undergoing orthopaedic surgery. They were allocated randomly to one of six groups which differed in time of nitrous oxide exposure and mode of ventilation. In order to simulate recovery conditions, nitrous oxide administration was discontinued after 30, 6...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/71.2.189
更新日期：1993-08-01 00:00:00
abstract：:The Myotest is a new nerve stimulator which can give train-of-four, single twitch (1 and 10 s) and tetanic stimuli. Power is supplied by standard batteries, which allow 200 h effective use. The impulse is unipolar constant current, and the amplitude can be adjusted between 0 and 40 mA. These factors, plus the electron...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/52.5.547
更新日期：1980-05-01 00:00:00
abstract：:Following a paravertebral surgical incision, mature, female rats under ether anaesthesia were exposed to either 3% nitrous oxide, continuously for 48 h, or 50% nitrous oxide, 4 h each day for 7 days. For each exposure group, a similar number of rats was exposed to atmospheres containing no nitrous oxide. Wound healing...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/57.6.621
更新日期：1985-06-01 00:00:00
abstract：Background:Cognitive aids improve the technical performance of individuals and teams dealing with high-stakes crises. Hand-held electronic cognitive aids have rarely been investigated. A randomized controlled trial was conducted to investigate the effects of a smartphone application, named MAX (for Medical Assistance e...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aex256
更新日期：2017-11-01 00:00:00
