Abstract：
:The sedation of 50 children aged 6 months to 9 years who had undergone open heart surgery was studied. During artificial ventilation a midazolam infusion was used in conjunction with the administration of morphine (and tubocurarine). Sedation for patients breathing spontaneously with positive airway pressure was continued with midazolam alone. The duration of the midazolam infusion (2-6 micrograms kg-1 min-1) ranged from 12 to 197 h. Forty-seven of the children were sedated uneventfully; the remaining three children needed small doses of other sedative agents. In 10 of the children, blood samples were taken for serum midazolam assay and a short Synacthen test was performed. There was no clinical evidence of accumulation of midazolam, but midazolam concentrations were so variable that no conclusions could be drawn. All patients in whom they were measured (n = 10) had high basal cortisol concentrations, but displayed normal responses to Synacthen.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Booker PD,Beechey A,Lloyd-Thomas ARdoi
10.1093/bja/58.10.1104subject
Has Abstractpub_date
1986-10-01 00:00:00pages
1104-8issue
10eissn
0007-0912issn
1471-6771pii
S0007-0912(17)39207-3journal_volume
58pub_type
杂志文章abstract：:We have examined changes in plasma concentrations of calcium in seven anaesthetized pigs during i.v. infusion of irrigating fluid containing 1.5% glycine. Volumes infused were 875 ml at 20 min (22 ml kg-1), 1475 ml at 40 min and 2075 ml at 60 min (75 ml kg-1). Plasma concentrations of sodium decreased from 134.5 (SD 3...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/77.2.271
更新日期：1996-08-01 00:00:00
abstract：:We have studied the effects of bilateral ilioinguinal nerve block and wound infiltration with 0.5% bupivacaine on postoperative pain and analgesic requirements in 62 patients undergoing Caesarean section under general anaesthesia. A control group received no local anaesthetic supplementation. Both ilioinguinal block a...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/72.2.229
更新日期：1994-02-01 00:00:00
abstract：BACKGROUND:The minimum alveolar concentration (MAC) is a traditional index of the hypnotic potency of an inhalational anaesthetic. To investigate the anaesthetic as well as the unwanted effects of xenon (Xe) in a swine model, it is useful to know MAC(Xe). METHODS:The study was performed using ten swine (weight 27.8-35...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aeh077
更新日期：2004-03-01 00:00:00
abstract：BACKGROUND:Single-lung ventilation in infants and small children is challenging because suitable sizes of double-lumen cuffed tracheal tubes are not available. A 6-yr-old child required pulmonary saline washout for primary alveolar proteinosis, and therefore needed sequential single-lung ventilation in order to achieve...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aev305
更新日期：2015-10-01 00:00:00
abstract：:This paper reports three investigations of the suggested relationship between sudden infant death syndrome (SIDS) and malignant hyperpyrexia (MH). In the first study 151 MH-susceptible families completed a questionnaire designed to identify the incidence of SIDS within their own pedigree. In the second study 106 SIDS ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/60.1.28
更新日期：1988-01-01 00:00:00
abstract：:Intraoperative awareness, with or without recall, continues to be a topic of clinical significance and neurobiological interest. In this article, we review evidence pertaining to the incidence, sequelae, and prevention of intraoperative awareness. We also assess which aspects of the complication are well understood (i...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1093/bja/aev034
更新日期：2015-07-01 00:00:00
abstract：:Hypertensive patients were monitored for myocardial ischaemia during anaesthesia and surgery with the V5 lead of a standard electrocardiograph. Myocardial ischaemia was detected in 11 of 39 untreated hypertensive patients and in four of seven receiving therapy with a diuretic, but in none of 44 receiving atenolol. Fou...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/61.6.675
更新日期：1988-12-01 00:00:00
abstract：:To assess the effect of sevoflurane anaesthesia on hepatocellular integrity, we measured plasma concentrations of glutathione S-transferase (GST) before anaesthesia and 1, 3, 6 and 24 h after the end of anaesthesia in 41 healthy, Japanese patients undergoing elective, body surface surgery. Sevoflurane (approximately 1...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/77.3.404
更新日期：1996-09-01 00:00:00
abstract：:We have investigated the effect of volatile anaesthetics on protein synthesis and secretion in Hartley male guinea pig liver slices. The slices (250-300 microns thick) were incubated in sealed roller vials containing Krebs-Henseleit buffer at 37 degrees C under 95% oxygen. Volatile anaesthetics were vaporized in the v...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/68.2.172
更新日期：1992-02-01 00:00:00
abstract：:This is the report of a 55-yr-old female who developed severe myotonia and dystonia after general anaesthesia. Before starting on gabapentin therapy for a neuropathic pain condition, she had undergone numerous uneventful general anaesthetics. Since receiving treatment with gabapentin, she has experienced severe moveme...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aem130
更新日期：2007-08-01 00:00:00
abstract：:Two groups of six patients were studied during light general anaesthesia using 2% enflurane and 66% nitrous oxide in oxygen, combined with regional anaesthesia, for hernia and varicose vein surgery. The effects of 3% enflurane were compared with those of fentanyl 0.3 microgram kg-1 i.v., by measuring inspired flow, ti...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/55.9.825
更新日期：1983-09-01 00:00:00
abstract：:We have examined the extradural space using a flexible extraduroscope in 74 patients undergoing extradural anaesthesia at the L2-3 interspace. Extraduroscopy showed that the extradural space becomes widely patent and the fatty tissue in the extradural space diminishes with increasing age. We postulate that these age-r...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/78.2.149
更新日期：1997-02-01 00:00:00
abstract：:Two patients are described in whom failure of the Pollard endotracheal tube produced complete respiratory obstruction. Comparisons are made of external diameters, resistance to gas flow and resistance to compression between Pollard tubes and several conventional tubes. It is concluded that the Pollard tube is not sati...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/49.2.179
更新日期：1977-02-01 00:00:00
abstract：:A retrospective study was carried out to determine analgesic requirements in a group of orthopaedic outpatients (n = 145) and oral surgery inpatients (n = 172). The orthopaedic patients received a codeine-paracetamol premedication, an opioid during operation, or no analgesic. Less than 50% of the orthopaedic patients ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/64.5.617
更新日期：1990-05-01 00:00:00
abstract：:We present a case where rocuronium 80 mg (3 x ED95) was used in a rapid sequence induction in a 80-kg pregnant patient with an open eye injury. The patient was also receiving magnesium 2 g h-1 i.v. for preterm labour. The expected duration for neuromuscular block of rocuronium in the absence of magnesium would be appr...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/77.5.669
更新日期：1996-11-01 00:00:00
abstract：:We have studied the effect of doxapram on the rates of spontaneous and neostigmine-induced recovery from neuromuscular block with atracurium and vecuronium, by measurement of the time to recovery of T1 (first twitch in the train-of-four) from 25 to 75% of control (recovery index, RI). After each neuromuscular blocking...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/68.5.527
更新日期：1992-05-01 00:00:00
abstract：:Maternal haemorrhage is the leading cause of preventable maternal death worldwide and encompasses antepartum, intrapartum, and postpartum bleeding. This review highlights factors that predispose to severe bleeding, its management, and the most recent treatment and guidelines. Advances in obstetric care have provided p...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1093/bja/aep303
更新日期：2009-12-01 00:00:00
abstract：:A new anaesthetic gas scavenging system is described. The resistance of the system appears to be low. When input gas flow rate in the system was zero or 150 litre min-1, misuse of the system produced pressure changes at its collecting points of 26 Pa subatmospheric and 630 Pa above atmospheric pressure, respectively. ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/55.7.681
更新日期：1983-07-01 00:00:00
abstract：BACKGROUND:To determine whether temperature and haematocrit (Hct) alter the relationship between blood flow (BF) and blood flow velocity (BFV). METHODS:Using a transcranial Doppler apparatus, we measured the peak velocity of whole blood cells pumped by a cardiopulmonary bypass (CPB) circuit, through a 0.15-cm internal...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/88.2.277
更新日期：2002-02-01 00:00:00
abstract：:Metoclopramide has been used for almost 40 yr to prevent postoperative nausea and vomiting (PONV). We have reviewed the efficacy and safety of metoclopramide for the prevention of PONV. A systematic search (MEDLINE, EMBASE, manufacturers' databases, hand searching, bibliographies, all languages, up to June 1998) was p...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,meta分析
doi：10.1093/bja/83.5.761
更新日期：1999-11-01 00:00:00
abstract：:General anaesthesia for emergency surgery in a pressurized habitat is likely to involve the use of i.v. agents. The anaesthetic property of such agents is known to be antagonized by pressure, but the effect on their duration of action is not easily predicted. The recovery of mice from a single i.v. dose of Althesin, k...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/53.5.455
更新日期：1981-05-01 00:00:00
abstract：BACKGROUND:Obstructive sleep apnoea (OSA) affects ~9-24% of the general population, and 90% remain undiagnosed. Those patients with undiagnosed moderate-to-severe OSA may be associated with an increased risk of perioperative complications. Our objective was to evaluate the proportion of surgical patients with undiagnos...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aes465
更新日期：2013-04-01 00:00:00
abstract：:Moderate to severe arterial oxygen desaturation (SaO2 75-88%) occurred in three of four patients who were given sedation during regional conduction block without the administration of oxygen. No desaturation occurred in six patients given oxygen 2 litre min-1 via a nasal catheter during similar procedures. It is concl...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章
doi：10.1093/bja/62.2.206
更新日期：1989-02-01 00:00:00
abstract：:One hundred and one patients with osteoarthritis were randomly allocated to undergo total hip arthroplasty under either spinal (subarachnoid) or general anaesthesia. Venous blood was sampled before, during and after surgery and on the 5th day after operation to study the haemostatic mechanism. There were no preoperati...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/59.5.561
更新日期：1987-05-01 00:00:00
abstract：:Fentanyl or alfentanil, in doses approximating to those used in clinical practice, was added to the priming fluid of an extracorporeal circuit before the institution of cardiopulmonary bypass (CPB). The concentrations of both drugs in the priming fluid were measured over a 20-min period. The concentration of fentanyl ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/58.9.947
更新日期：1986-09-01 00:00:00
abstract：BACKGROUND:The molecular actions underlying the clinical effects of inhaled anaesthetics such as sevoflurane and isoflurane are not fully understood. Unexpected observations in positron emission tomography (PET) studies with [11C]AZD9272, a metabotropic glutamate receptor 5 (mGluR5) radioligand with possible affinity f...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2020.08.052
更新日期：2021-01-01 00:00:00
abstract：:The new emulsion formulation of di-isopropyl phenol (propofol) was compared with methohexitone and thiopentone for induction of anaesthesia in day cases. Propofol produced significantly smoother induction of anaesthesia, but caused more cardiovascular and respiratory depression. Pain on injection was significantly les...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/57.8.725
更新日期：1985-08-01 00:00:00
abstract：BACKGROUND:Dexmedetomidine (DEX) is increasingly used intraoperatively in infants undergoing cardiac surgery. This phase 1 multicentre study sought to: (i) determine the safety of DEX for cardiac surgery with cardiopulmonary bypass; (ii) determine the pharmacokinetics (PK) of DEX; (iii) create a PK model and dosing for...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,多中心研究
doi：10.1016/j.bja.2019.06.026
更新日期：2019-12-01 00:00:00
abstract：:We have studied the effects of amrinone on left and right ventricular haemodynamics in patients with impaired ventricular performance caused by coronary artery disease. Anaesthesia was achieved with fentanyl, flunitrazepam and pancuronium. After reaching steady state, a bolus dose of amrinone 0.5 mg kg-1 was administe...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/72.5.567
更新日期：1994-05-01 00:00:00
abstract：:Using human nasal cytological brushings, we have investigated the effects of morphine on ciliary function by measurement of cilia beat frequency in vitro, and we have also determined opioid receptor binding in these specimens. We obtained ciliated samples from seven volunteers, and measured cilia beat frequency using ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/76.2.274
更新日期：1996-02-01 00:00:00
