Effect of doxapram on the rate of recovery from atracurium and vecuronium neuromuscular block.

Abstract:

:We have studied the effect of doxapram on the rates of spontaneous and neostigmine-induced recovery from neuromuscular block with atracurium and vecuronium, by measurement of the time to recovery of T1 (first twitch in the train-of-four) from 25 to 75% of control (recovery index, RI). After each neuromuscular blocking drug, RI was measured without administering either doxapram or neostigmine (control group), or after administration of doxapram 1 mg kg-1, neostigmine 50 micrograms kg-1 or a combination of doxapram and neostigmine, in groups of 10 patients. RI was significantly longer after vecuronium in the presence of doxapram compared with control (20.1 min vs 14.6 min). There was no significant difference in the RI after atracurium in the presence of doxapram compared with control (12.5 min vs 11.8 min) or when neostigmine was administered with or without doxapram (2.4 min vs 2.4 min, respectively after vecuronium; 3.3 min vs 2.9 min, respectively, after atracurium).

journal_name

Br J Anaesth

authors

Cooper R,McCarthy G,Mirakhur RK,Maddineni VR

doi

10.1093/bja/68.5.527

subject

Has Abstract

pub_date

1992-05-01 00:00:00

pages

527-8

issue

5

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)46621-9

journal_volume

68

pub_type

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