Comparison of the effects of thoracic and lumbar epidural anaesthesia on induction and maintenance doses of propofol during total i.v. anaesthesia.

Abstract:

BACKGROUND:In this randomized, double-blind study, the effects of thoracic and lumbar epidural anaesthesia on the induction doses (IDs) and maintenance doses (MDs) of propofol during bispectral index (BIS) guided total i.v. anaesthesia were compared. METHODS:Fifty-four patients (three groups, n=18 each) undergoing urological surgery in lumbotomy position were studied in Groups T (Th7-8) and L (L3-4), epidural anaesthesia was performed with initial doses obtaining sensorial block at Th4 (sd 1) followed by 7 ml h(-1) infusion; Group C received no epidural anaesthesia intraoperatively. The ID (BIS <45) and MD (BIS: 40-50) of propofol and recovery (BIS >80) and extubation times were recorded. RESULTS:The volume to obtain a block was significantly lower in Group T than in Group L [10.7 (1.5) vs 14.7 (1.0) ml; P<0.001]. ID was significantly higher in Group C compared with that in Groups T and L [2.16 (0.15) vs 1.33 (0.19) vs 1.46 (0.14) mg kg(-1), respectively; P<0.001] with no significant difference between Groups T and L. For MD, there were significant differences between all groups [3.82 (0.9) vs 5.8 (1.32) vs 9.21 (0.55) mg kg(-1) h(-1) in Groups T, L, and C, respectively; P<0.001]. For recovery and extubation times, Group T

journal_name

Br J Anaesth

authors

Sentürk M,Güçyetmez B,Ozkan-Seyhan T,Karadeniz M,Dinçer S,Akpir D,Sengül T,Denkel T

doi

10.1093/bja/aen160

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

255-60

issue

2

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)34243-5

journal_volume

101

pub_type

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