The effect of age on the safety factor in neuromuscular transmission in the isolated diaphragm of the rat.

abstract：:Advances in cannabis research have paralleled developments in opioid pharmacology whereby a psychoactive plant extract has elucidated novel endogenous signalling systems with therapeutic significance. Cannabinoids (CBs) are chemical compounds derived from cannabis. The major psychotropic CB delta-9-tetrahydrocannabino...

journal_title：British journal of anaesthesia

authors： Hosking RD,Zajicek JP

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Hip fracture is a condition with high mortality and morbidity in elderly frail patients. Intraoperative fluid optimization may be associated with benefit in this population. We investigated whether intraoperative fluid management using pulse-contour analysis cardiac monitoring, compared with standard care in...

journal_title：British journal of anaesthesia

authors： Moppett IK,Rowlands M,Mannings A,Moran CG,Wiles MD,NOTTS Investigators.

更新日期：2015-03-01 00:00:00

abstract：:Midazolam 0.3 mg kg-1 was given as a single dose to three groups of children undergoing cardiac surgery to determine its pharmacokinetic profile in this situation. The first group, undergoing closed heart surgery, received the midazolam during the operation. The other groups underwent cardiopulmonary bypass (CPB) with...

journal_title：British journal of anaesthesia

authors： Mathews HM,Carson IW,Lyons SM,Orr IA,Collier PS,Howard PJ,Dundee JW

更新日期：1988-09-01 00:00:00

abstract：:We have studied the effect of tropisetron, a 5-HT3-receptor antagonist, on postoperative nausea, vomiting and pain in 54 patients, aged 50-83 yr, after major hip or knee surgery. The patients were given subarachnoid injection of plain 0.5% bupivacaine, mixed with preservative-free morphine 0.3 mg, for surgical and pos...

journal_title：British journal of anaesthesia

authors： Pitkänen MT,Niemi L,Tuominen MK,Rosenberg PH

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:In 2016, the World Health Organization (WHO) strongly recommended the use of a high fraction of inspired oxygen (FiO2) in adult patients undergoing general anaesthesia to reduce the risk of surgical site infection (SSI). Since then, further trials have been published, trials included previously have come und...

journal_title：British journal of anaesthesia

authors： de Jonge S,Egger M,Latif A,Loke YK,Berenholtz S,Boermeester M,Allegranzi B,Solomkin J

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:The therapeutic potential of cardiac μ-opioid receptors in ischaemia-reperfusion (I/R) injury during opioid-modulating diseases, such as heart failure, is unknown. We aimed to explore the changes of cardiac μ-opioid receptor expression during heart failure, and its role in opioid-induced cardioprotection. M...

journal_title：British journal of anaesthesia

authors： He SF,Jin SY,Yang W,Pan YL,Huang J,Zhang SJ,Zhang L,Zhang Y

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:The objective of the present study was to investigate the effects of increasing doses of norepinephrine (NE) with or without arginine-vasopressin (AVP) on intestinal oxygen supply and jejunal mucosal tissue oxygen tension in an acute endotoxic pig model. METHODS:In this prospective, randomized, experimental...

journal_title：British journal of anaesthesia

authors： Maier S,Hasibeder W,Pajk W,Hengl C,Ulmer H,Hausdorfer H,Wurzinger B,Knotzer H

更新日期：2009-11-01 00:00:00

abstract：:Prolongation of the QT interval of the ECG represents an imbalance in cardiac autonomic function and may predict cardiac arrhythmia. Vagal activity protects against prolongation of the QT interval which may be associated with flattening of the T-wave of the ECG. The changes in QT interval, T-wave amplitude and respira...

journal_title：British journal of anaesthesia

authors： Annila P,Yli-Hankala A,Lindgren L

更新日期：1993-11-01 00:00:00

abstract：:The effect of the combination of opiates and hypnotics on bispectral index (BIS) is unclear. This double-blind placebo-controlled trial investigated the effect on BIS and sedation of different infusion doses of remifentanil combined with a steady infusion of propofol. Forty patients initially received a target-control...

journal_title：British journal of anaesthesia

authors： Strachan AN,Edwards ND

更新日期：2000-04-01 00:00:00

abstract：:We studied the effects of minor surgery and endotracheal intubation on postoperative breathing patterns. We measured breathing patterns and laryngeal resistance during the periods immediately before intubation (preoperative) and immediately after extubation following minor surgery (postoperative) in eight patients ana...

journal_title：British journal of anaesthesia

authors： Tanaka A,Isono S,Sato J,Nishino T

更新日期：2001-11-01 00:00:00

abstract：:The induction dose requirements of propofol were compared in three age groups in 300 unpremedicated healthy Chinese children: group A, younger than 2 yr (n = 48); group B, 2-5 yr (n = 117); group C, 6-12 yr (n = 135). Patients in each group were allocated randomly to receive one of eight doses of propofol (1.2, 1.4, 1...

journal_title：British journal of anaesthesia

authors： Aun CS,Short SM,Leung DH,Oh TE

更新日期：1992-01-01 00:00:00

abstract：:In order to evaluate the use of the post-tetanic count (PTC) method during repetitive administration of vecuronium, we studied 20 patients allocated randomly to one of two groups: 10 patients received droperidol-fentanyl anaesthesia (control group); 10 other patients were given droperidol-fentanyl anaesthesia modified...

journal_title：British journal of anaesthesia

authors： Eriksson LI,Lennmarken C,Staun P,Viby-Mogensen J

更新日期：1990-10-01 00:00:00

abstract：:In nine patients, undergoing repeat operations because of severe intra-abdominal infection developing after major abdominal surgery, serum potassium concentrations were monitored during induction of anaesthesia. Four patients showed an increase of serum potassium ranging from 2.5 to 3.1 mmol/litre above baseline value...

journal_title：British journal of anaesthesia

authors： Kohlschütter B,Baur H,Roth F

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:The ProSeal laryngeal mask airway (PLMA) is a new laryngeal mask device with a modified cuff and a drainage tube. METHODS:We assessed the PLMA in 300 anaesthetized adults either paralysed or breathing spontaneously. We assessed insertion characteristics, airway seal pressures, haemodynamic response to inser...

journal_title：British journal of anaesthesia

authors： Evans NR,Gardner SV,James MF,King JA,Roux P,Bennett P,Nattrass R,Llewellyn R,Visu D

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:The goal of the study was to determine activated thrombelastographic (TEG(R)) parameters with the rotational TEG(R) (ROTEG or ROTEM) device (Pentapharm GmbH, Munich, Germany) in neonates and infants <1 yr with complex congenital heart disease (CCHD) and to compare them with those of healthy children. METHOD...

journal_title：British journal of anaesthesia

authors： Haizinger B,Gombotz H,Rehak P,Geiselseder G,Mair R

更新日期：2006-10-01 00:00:00

abstract：:Chinese hamster fibroblast cells in stirred suspension cultures were exposed to volatile anaesthetic agents for 3 hr or for 24 hr. Cell viability was measured as colony forming ability and was found to be reduced, in a dose related manner, by halothane, chloroform, methoxyflurane, trichloroetheylene and diethyl ether....

journal_title：British journal of anaesthesia

authors： Sturrock JE

更新日期：1975-08-01 00:00:00

abstract：:Cis AB blood group is a rare variant of the AB blood group resulting from inheritance of both A and B genes on one chromosome. It may lead to misclassification in ABO grouping and clinical misdiagnosis as a result of its divergence from the laws of Landsteiner and Mendel. We encountered a case of cis AB blood group, a...

journal_title：British journal of anaesthesia

authors： Kawahito S,Kitahata H,Kimura H,Tanaka K,Oshita S

更新日期：1999-09-01 00:00:00

abstract：:We have assessed a prototype laryngeal mask airway (pLMA) in 50 anaesthetized children for ease of insertion, oropharyngeal leak pressures, gastric insufflation and fibreoptic position. The pLMA has a second smaller mask, which rests against the upper oesophageal sphincter, and a second cuff to increase the seal press...

journal_title：British journal of anaesthesia

authors： Lopez-Gil M,Brimacombe J,Brain AI

更新日期：1999-01-01 00:00:00

abstract：:We have studied the plasma concentrations (Cp) and pharmacokinetics of sufentanil injected i.v. (IVS), intradurally (IS) or extradurally (ES) under general anaesthesia in 31 patients undergoing major abdominal surgery. Sufentanil appeared in plasma very rapidly and Cpmax was also attained rapidly after both extradural...

journal_title：British journal of anaesthesia

authors： Ionescu TI,Taverne RH,Houweling PL,Drost RH,Nuijten S,Van Rossum J

更新日期：1991-04-01 00:00:00

abstract：:An oxygen consuming lung model was used for evaluation and validation of a technique for metabolic gas exchange measurements during controlled ventilation. The technique comprised a Servo 900 C ventilator (Siemens) and separate oxygen and carbon dioxide analysers (Beckman). Measurements of oxygen consumption and carbo...

journal_title：British journal of anaesthesia

authors： Svensson KL,Sonander HG,Stenqvist O

更新日期：1990-03-01 00:00:00

abstract：:The value of the continuous monitoring of end-tidal carbon dioxide concentration as an indicator of the acute intraoperative interruption of pulmonary blood flow, in patients with pre-existing restrictions of pulmonary blood flow undergoing closed heart surgery, is illustrated by two case reports. Decreases in end-tid...

journal_title：British journal of anaesthesia

authors： Schuller JL,Bovill JG,Nijveld A

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:Dexmedetomidine is an α-2-receptor agonist which might be used as an additive to local anaesthetics for various regional anaesthetic techniques. We therefore designed this prospective, double-blinded, controlled volunteer study to investigate the effects of dexmedetomidine as an adjuvant to ropivacaine on pe...

journal_title：British journal of anaesthesia

authors： Marhofer D,Kettner SC,Marhofer P,Pils S,Weber M,Zeitlinger M

更新日期：2013-03-01 00:00:00

abstract：:Frailty is a syndrome of cumulative decline across multiple physiological systems, which predisposes vulnerable adults to adverse events. Assessing vulnerable patients can potentially lead to interventions that improve surgical outcomes. Anaesthesiologists who care for older patients can identify frailty to improve pr...

journal_title：British journal of anaesthesia

authors： Bentov I,Kaplan SJ,Pham TN,Reed MJ

更新日期：2019-07-01 00:00:00

abstract：:We describe a scavenging device, primarily for use during inhalation induction of anaesthesia in children; it was designed to optimize the often conflicting requirements of clinical acceptability and adequate gas collection. The performance was assessed in three ways. The device reduced the nitrous oxide concentration...

journal_title：British journal of anaesthesia

authors： Sik MJ,Lewis RB,Eveleigh DJ

更新日期：1990-01-01 00:00:00

abstract：:A new design of tracheal tube cuff was compared with two types of high-volume, low-pressure (HVLP) cuffed tracheal tube for leakage of fluid from the subglottic space into the trachea. Spontaneous and positive-pressure ventilation were simulated using a mechanical lung, an intubated model trachea and a ventilator. Exc...

journal_title：British journal of anaesthesia

authors： Young PJ,Ridley SA,Downward G

更新日期：1998-06-01 00:00:00

abstract：:Fentanyl or alfentanil, in doses approximating to those used in clinical practice, was added to the priming fluid of an extracorporeal circuit before the institution of cardiopulmonary bypass (CPB). The concentrations of both drugs in the priming fluid were measured over a 20-min period. The concentration of fentanyl ...

journal_title：British journal of anaesthesia

authors： Skacel M,Knott C,Reynolds F,Aps C

更新日期：1986-09-01 00:00:00

abstract：:One hundred and one patients with osteoarthritis were randomly allocated to undergo total hip arthroplasty under either spinal (subarachnoid) or general anaesthesia. Venous blood was sampled before, during and after surgery and on the 5th day after operation to study the haemostatic mechanism. There were no preoperati...

journal_title：British journal of anaesthesia

authors： Davis FM,McDermott E,Hickton C,Wells E,Heaton DC,Laurenson VG,Gillespie WJ,Foate J

更新日期：1987-05-01 00:00:00

abstract：Background:Checklists can reduce medical errors. However, the effectiveness of checklists is hampered by lack of acceptance and compliance. Recently, a new type of checklist with dynamic properties has been created to provide more specific checklist items for each individual patient. Our purpose in this simulation-base...

journal_title：British journal of anaesthesia

authors： De Bie AJR,Nan S,Vermeulen LRE,Van Gorp PME,Bouwman RA,Bindels AJGH,Korsten HHM

更新日期：2017-08-01 00:00:00

abstract：:Thrombelastography (TEG) correlates with postoperative chest drain output in patients undergoing cardiopulmonary bypass (CPB). In vitro incubation with heparinase allows TEG monitoring during CPB, despite heparin anticoagulation. Hypothermia impairs coagulation, but these effects cannot be assessed by standard coagula...

journal_title：British journal of anaesthesia

authors： Kettner SC,Kozek SA,Groetzner JP,Gonano C,Schellongowski A,Kucera M,Zimpfer M

更新日期：1998-03-01 00:00:00

abstract：:Plasma diazepam concentrations were determined following oral, i.m. and i.v. administration to a group of pregnant women with pre-eclampsia and a group of normal pregnant women. Diazepam concentrations were greater following oral as compared with i.m. administration in the control group, who received a single 5-mg dos...

journal_title：British journal of anaesthesia

authors： Sturdee DW

更新日期：1976-11-01 00:00:00