Aerosolized surfactant therapy for endotoxin-induced experimental acute respiratory distress syndrome in rats.


:We have compared the effects of inhalation of aerosolized surfactant on experimental acute respiratory distress syndrome. Escherichia coli endotoxin (55 (SD 20) mg kg(-1)) was injected into the tracheas of 36 adult rats anaesthetized and mechanically ventilated with pure oxygen. When the Pa(O(2)) decreased to 11.3 (3.3) kPa, the animals were randomly subjected to inhalation of aerosolized modified natural surfactant (MNS) for 0 min (control group), 30, 60, and 120 min. In the control group, Pa(O(2)) remained below 12 kPa for 180 min. In the groups receiving inhalation of surfactant for 30 and 60 min, Pa(O(2)) increased but decreased soon after termination of the inhalation. In contrast, Pa(O(2)) of the group receiving inhalation of surfactant for 120 min continued to increase, reaching 52.1 (12.5) kPa at 180 min (P<0.05 vs control). Thus, we conclude that improvement in gas exchange as a result of inhalation of MNS depends on the duration of inhalation.


Br J Anaesth


Tashiro K,Yamada K,Konzaki T,Yamamoto K,Ohmura S,Kobayashi T,Suzuki Y




Has Abstract


2001-08-01 00:00:00














  • Minimum alveolar concentration (MAC) of xenon in intubated swine.

    abstract:BACKGROUND:The minimum alveolar concentration (MAC) is a traditional index of the hypnotic potency of an inhalational anaesthetic. To investigate the anaesthetic as well as the unwanted effects of xenon (Xe) in a swine model, it is useful to know MAC(Xe). METHODS:The study was performed using ten swine (weight 27.8-35...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Hecker KE,Horn N,Baumert JH,Reyle-Hahn SM,Heussen N,Rossaint R

    更新日期:2004-03-01 00:00:00

  • Analgesic side effects and minor surgery: which analgesic for minor and day-case surgery?

    abstract::A retrospective study was carried out to determine analgesic requirements in a group of orthopaedic outpatients (n = 145) and oral surgery inpatients (n = 172). The orthopaedic patients received a codeine-paracetamol premedication, an opioid during operation, or no analgesic. Less than 50% of the orthopaedic patients ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Campbell WI

    更新日期:1990-05-01 00:00:00

  • Developmental pharmacokinetics of morphine and its metabolites in neonates, infants and young children.

    abstract:BACKGROUND:Descriptions of the pharmacokinetics and metabolism of morphine and its metabolites in young children are scant. Previous studies have not differentiated the effects of size from those related to age during infancy. METHODS:Postoperative children 0-3 yr old were given an intravenous loading dose of morphine...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bouwmeester NJ,Anderson BJ,Tibboel D,Holford NH

    更新日期:2004-02-01 00:00:00

  • Comparison of CNS effects of propofol and thiopentone in cats.

    abstract::Using cats with chronically implanted brain electrodes, we have compared the effects of propofol on CNS electrical activities with those of thiopentone. Ten cats were allocated to receive either propofol (n = 5) or thiopentone (n = 5). Cats were anaesthetized initially with 4% halothane in oxygen. The trachea was intu...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Tomoda K,Shingu K,Osawa M,Murakawa M,Mori K

    更新日期:1993-09-01 00:00:00

  • The intubating laryngeal mask airway compared with direct laryngoscopy.

    abstract::We have compared the ability of naïve intubators to intubate the trachea using a laryngoscope and an intubating laryngeal mask airway (ILMA) after receiving basic training, in a randomized, prospective, crossover study in 60 patients. Ventilation of the lungs via the ILMA was also compared with ventilation with a face...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Avidan MS,Harvey A,Chitkara N,Ponte J

    更新日期:1999-10-01 00:00:00

  • Clinical observations on the neuromuscular blocking action of Org 9426, a new steroidal non-depolarizing agent.

    abstract::The neuromuscular blocking effects of Org 9426, the 2-morpholino, 16-allyl-pyrrolidino derivative of the 3-desacetoxy analogue of vecuronium have been investigated in anaesthetized patients. Based on data from a pilot study, two doses, 250 and 500 micrograms kg-1 (estimated as the ED90 and 2 x ED90, respectively) were...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章


    authors: Wierda JM,de Wit AP,Kuizenga K,Agoston S

    更新日期:1990-04-01 00:00:00

  • Differentiating the cellular and humoral components of neuromuscular blocking agent-induced anaphylactic reactions in patients undergoing anaesthesia.

    abstract:BACKGROUND:The significance of IgE antibodies to neuromuscular blocking agent (NMBA)-induced anaphylactic reactions during anaesthesia is unclear. We investigated the relevance of IgE to rocuronium using an in vitro technique. METHODS:Serum samples from 61 patients with anaphylactic reactions during anaesthesia were i...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Aalberse RC,Kleine Budde I,Mulder M,Stapel SO,Paulij W,Leynadier F,Hollmann MW

    更新日期:2011-05-01 00:00:00

  • Effect of low and high concentrations of alfentanil administered intrathecally on A delta and C fibre mediated somatosympathetic reflexes.

    abstract::We have studied the effects of alfentanil administered intrathecally on somatosympathetic reflexes evoked by stimulation of radial and tibial nerves in 10 anaesthetized and paralysed dogs. In five animals, alfentanil was administered in doses of 100, 100, 200 and 400 micrograms in 0.8 ml and 800 micrograms in 1.6 ml p...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Wang C,Chakrabarti MK,Whitwam JG

    更新日期:1992-05-01 00:00:00

  • Pain in cancer survivors; filling in the gaps.

    abstract::Cancer survivorship represents a growing clinical challenge for pain clinicians. The population of cancer survivors is rapidly expanding and many of these patients experience pain as a sequelae of their disease and its treatment. The features, pathophysiology and natural history of some painful conditions observed in ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审


    authors: Brown M,Farquhar-Smith P

    更新日期:2017-10-01 00:00:00

  • A fine balance--one-lung ventilation in a patient with Eisenmenger syndrome.

    abstract::A 38-yr-old woman with an atrial septum defect and Eisenmenger syndrome was scheduled for a lung biopsy via thoracoscopy during one-lung ventilation. Fluids were given to increase central venous pressure to 8 mm Hg, an epidural catheter was inserted at the sixth thoracic intervertebral space and ropivacaine 0.3%, 6 ml...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Heller AR,Litz RJ,Koch T

    更新日期:2004-04-01 00:00:00

  • A consensus checklist to help clinicians interpret clinical trial results analysed by Bayesian methods.

    abstract:INTRODUCTION:In the context of an increasing number of publications of trial data analysed by Bayesian methods, clinicians need support to better understand Bayesian statistical methods. The existing checklists are intended for people who already know these methods. We aimed to establish and validate a checklist that c...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Ferreira D,Barthoulot M,Pottecher J,Torp KD,Diemunsch P,Meyer N

    更新日期:2020-08-01 00:00:00

  • Effect of i.v. ketamine in combination with epidural bupivacaine or epidural morphine on postoperative pain and wound tenderness after renal surgery.

    abstract::We studied 60 patients undergoing operation on the kidney with combined general and epidural anaesthesia, in a double-blind, randomized, controlled study. Patients were allocated to receive a preoperative bolus dose of ketamine 10 mg i.v., followed by an i.v. infusion of ketamine 10 mg h-1 for 48 h after operation, or...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ilkjaer S,Nikolajsen L,Hansen TM,Wernberg M,Brennum J,Dahl JB

    更新日期:1998-11-01 00:00:00

  • Randomized trial of red cell washing for the prevention of transfusion-associated organ injury in cardiac surgery.

    abstract:Background:Experimental studies suggest that mechanical cell washing to remove pro-inflammatory components that accumulate in the supernatant of stored donor red blood cells (RBCs) might reduce inflammation and organ injury in transfused patients. Methods:Cardiac surgery patients at increased risk of large-volume RBC ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Wozniak MJ,Sullo N,Qureshi S,Dott W,Cardigan R,Wiltshire M,Morris T,Nath M,Bittar N,Bhudia SK,Kumar T,Goodall AH,Murphy GJ

    更新日期:2017-05-01 00:00:00

  • Spinal anaesthesia for paediatric day-case surgery: a double-blind, randomized, parallel group, prospective comparison of isobaric and hyperbaric bupivacaine.

    abstract::We have compared bupivacaine 5 mg ml-1, either isobaric in saline 0.9% or hyperbaric in 8% glucose, for spinal anaesthesia in 100 children, aged 2-115 months, in a double-blind, randomized, parallel group, prospective study. Children were premedicated with diazepam 0.5 mg kg-1 orally. Seventy-two children were sedated...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kokki H,Tuovinen K,Hendolin H

    更新日期:1998-10-01 00:00:00

  • Different effects of dopamine and dopexamine on the isolated perfused rat kidney.

    abstract::We have investigated the effect of dopamine and dopexamine on the isolated perfused rat kidney. After an equilibration period of 20 min and two control periods of 10 min, dopexamine 1.0, 2.5 or 4.0 micrograms kg-1 min-1 or dopamine 2.0 micrograms kg-1 min-1 were perfused for a further 40 min in random order. Renal blo...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Kirchhoff K,Leuwer M,Thum P,Bornscheuer A,Piepenbrock S

    更新日期:1999-12-01 00:00:00

  • Total i.v. anaesthesia with propofol and alfentanil: dose requirements for propofol and the effect of premedication with clonidine.

    abstract::We determined in 51 healthy patients undergoing body surface surgery the dose requirements for propofol, as part of a total i.v. anaesthesia technique with an alfentanil infusion. After premedication with temazepam, patients received alfentanil 50 micrograms kg-1 followed by an infusion of 50 micrograms kg-1 h-1. Pati...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章


    authors: Richards MJ,Skues MA,Jarvis AP,Prys-Roberts C

    更新日期:1990-08-01 00:00:00

  • Levobupivacaine vs bupivacaine as infiltration anaesthesia in inguinal herniorrhaphy.

    abstract::We have compared the anaesthetic and analgesic efficacy of levobupivacaine with that of racemic bupivacaine in 66 male patients undergoing ambulatory primary inguinal herniorrhaphy. Patients were allocated randomly in a double-blind manner to local infiltration anaesthesia (0.25% w/v 50 ml) with either racemic bupivac...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bay-Nielsen M,Klarskov B,Bech K,Andersen J,Kehlet H

    更新日期:1999-02-01 00:00:00

  • Mitochondrial redox state in the critically ill.

    abstract::Abnormal oxygen use and organ failure in the critically ill may result from 'poisoning' of mitochondrial function. Measurement of arterial ketone body ratio (AKBR) has been proposed to reflect mitochondrial redox state and may provide a useful marker to monitor mitochondrial function in the critically ill. We measured...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Yassen KA,Galley HF,Lee A,Webster NR

    更新日期:1999-08-01 00:00:00

  • Neostigmine with glycopyrrolate does not increase the incidence or severity of postoperative nausea and vomiting in outpatients undergoing gynaecological laparoscopy.

    abstract::We studied 100 healthy women undergoing outpatient gynaecological laparoscopy in a randomized, double-blind and placebo-controlled study to evaluate the effect of neostigmine on postoperative nausea and vomiting (PONV). After induction of anaesthesia with propofol, anaesthesia was maintained with sevoflurane and 66% n...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Nelskylä K,Yli-Hankala A,Soikkeli A,Korttila K

    更新日期:1998-11-01 00:00:00

  • Intelligent dynamic clinical checklists improved checklist compliance in the intensive care unit.

    abstract:Background:Checklists can reduce medical errors. However, the effectiveness of checklists is hampered by lack of acceptance and compliance. Recently, a new type of checklist with dynamic properties has been created to provide more specific checklist items for each individual patient. Our purpose in this simulation-base...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验


    authors: De Bie AJR,Nan S,Vermeulen LRE,Van Gorp PME,Bouwman RA,Bindels AJGH,Korsten HHM

    更新日期:2017-08-01 00:00:00

  • Opioid-induced hyperalgesia in patients after surgery: a systematic review and a meta-analysis.

    abstract:BACKGROUND:Opioids can increase sensitivity to noxious stimuli and cause opioid-induced hyperalgesia. We performed a systematic review to evaluate the clinical consequences of intra-operative doses of opioid. METHODS:We identified randomized controlled trials which compared intra-operative opioid to lower doses or pla...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,meta分析,评审


    authors: Fletcher D,Martinez V

    更新日期:2014-06-01 00:00:00

  • Covert stroke after non-cardiac surgery: a prospective cohort study.

    abstract:BACKGROUND:Overt stroke after non-cardiac surgery has a substantial impact on the duration and quality of life. Covert stroke in the non-surgical setting is much more common than overt stroke and is associated with an increased risk of cognitive decline and dementia. Little is known about covert stroke after non-cardia...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,多中心研究


    authors: Mrkobrada M,Hill MD,Chan MT,Sigamani A,Cowan D,Kurz A,Sessler DI,Jacka M,Graham M,Dasgupta M,Dunlop V,Emery DJ,Gulka I,Guyatt G,Heels-Ansdell D,Murkin J,Pettit S,Sahlas DJ,Sharma M,Sharma M,Srinathan S,St John P

    更新日期:2016-08-01 00:00:00

  • Comparison of esCCO and transthoracic echocardiography for non-invasive measurement of cardiac output intensive care.

    abstract:BACKGROUND:The esCCO monitor (ECG- estimated Continuous Cardiac Output, Nihon Kohden(®)) is a new non-invasive tool for estimating cardiac output (CO). It derives CO from the pulse wave transit time (PWTT) estimated by the ECG and the plethysmographic wave. An initial calibration is needed to refine the relation linkin...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Bataille B,Bertuit M,Mora M,Mazerolles M,Cocquet P,Masson B,Moussot PE,Ginot J,Silva S,Larché J

    更新日期:2012-12-01 00:00:00

  • Low-dose ketamine affects immune responses in humans during the early postoperative period.

    abstract:BACKGROUND:Anaesthesia and surgery are associated with impairment of the immune system expressed as an excessive proinflammatory immune response and suppression of cell-mediated immunity that may affect the course of the postoperative period. Addition of anaesthetic agents capable of attenuating the alterations in peri...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验


    authors: Beilin B,Rusabrov Y,Shapira Y,Roytblat L,Greemberg L,Yardeni IZ,Bessler H

    更新日期:2007-10-01 00:00:00

  • Anaesthesia and intensive care management of face transplantation.

    abstract::The face-grafting techniques are innovative and highly complex, requiring well-defined organization of all the teams involved. Subsequent to the first report in France in 2005, there have been 17 facial allograft transplantations performed worldwide. We describe anaesthesia and postoperative management, and the proble...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Sedaghati-nia A,Gilton A,Liger C,Binhas M,Cook F,Ait-Mammar B,Scherrer E,Hivelin M,Lantieri L,Marty J,Plaud B

    更新日期:2013-10-01 00:00:00

  • Cardiovascular and neuromuscular effects of dimethyl tubocurarine in anaesthetized cats and rhesus monkeys.

    abstract::Intravenous dose-response relationships for dimethyl tubocurarine showed that vagal blockade only became appreciable (50-83%) at doses 8-16 times those sufficient for full neuromuscular paralysis in anaesthetized cats (0.0625 mg/kg) and rhesus monkeys (0.125 mg/kg); heart rate was unchanged. Sympathetic function was u...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Hughes R,Chapple DJ

    更新日期:1976-09-01 00:00:00

  • The minimum reservoir capacity necessary to avoid air-dilution. An experimental model of spontaneous breathing through a T-piece.

    abstract::The fresh gas flow rate necessary to prevent rebreathing in T-piece anaesthesia is well established at twice total ventilation. The minimum reservoir volume to avoid air dilution of anaesthetic gases in the alveolus at this flow rate is, however, undecided. A lung model was constructed to represent spontaneous respira...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Naunton A

    更新日期:1985-08-01 00:00:00

  • Monitoring of end-tidal carbon dioxide partial pressure during high frequency jet ventilation.

    abstract::A new method has been developed to measure end-tidal carbon dioxide partial pressure (PECO2) during high frequency jet ventilation (HFJV). A digital flow controller incorporated in a computerized high frequency jet ventilator was used to deliver either a single deep breath or a series of three deep breaths. On user re...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Sehati S,Young JD,Sykes MK,McLeod CN

    更新日期:1989-01-01 00:00:00

  • Impact of echocardiography on patient management in the intensive care unit: an audit of district general hospital practice.

    abstract:BACKGROUND:Echocardiography has been shown to positively impact on the management of the critically ill patient. However, many published studies have a significant bias towards inclusion of cardiothoracic patients. We present an audit of the impact of echocardiography on the management of patients in a district general...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Orme RM,Oram MP,McKinstry CE

    更新日期:2009-03-01 00:00:00

  • Pharmacokinetics of atracurium besylate in healthy patients (after a single i.v. bolus dose).

    abstract::The plasma decay of atracurium besylate was examined in two groups of six patients. Group I received atracurium 0.6 mg kg-1 and group II 0.3 mg kg-1 as a single bolus dose i.v. The plasma concentrations were measured by high performance liquid chromatography. An individual two-compartment pharmacokinetic model was use...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章


    authors: Ward S,Neill EA,Weatherley BC,Corall IM

    更新日期:1983-02-01 00:00:00