Addition of meperidine to bupivacaine for spinal anaesthesia for Caesarean section.

Abstract:

BACKGROUND:In a prospective, randomized, double-blind, placebo-controlled trial, we investigated the effect of adding meperidine 10 mg to intrathecal bupivacaine on the duration of early postoperative analgesia in 40 patients having elective Caesarean section under spinal anaesthesia. METHODS:Patients received intrathecal injection of 0.5% hyperbaric bupivacaine 2.0 ml plus either normal saline 0.2 ml (saline group) or 5% meperidine 0.2 ml (meperidine group). After operation, all patients were given i.v. patient-controlled analgesia using morphine. RESULTS:The duration of effective analgesia, defined as the time from intrathecal injection to first patient-controlled analgesia demand, was greater in the meperidine group (mean 234 min, 95% confidence interval 200-269 min) compared with the saline group (mean 125 min, 95% confidence interval 111-138 min; P<0.001). The 24 h morphine requirement was similar in the two groups. The meperidine group had a greater incidence of intraoperative nausea or vomiting compared with the saline group (11 vs 3; P=0.02). CONCLUSION:Addition of meperidine 10 mg to intrathecal bupivacaine for Caesarean section is associated with prolonged postoperative analgesia but with greater intraoperative nausea and vomiting.

journal_name

Br J Anaesth

authors

Yu SC,Ngan Kee WD,Kwan AS

doi

10.1093/bja/88.3.379

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

379-83

issue

3

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)36508-X

journal_volume

88

pub_type

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