Nausea and vomiting after gynaecological surgery: a meta-analysis of factors affecting their incidence.

Abstract:

:A total of 1442 patients who had major gynaecological surgery were recruited into three multicentre studies using a standard general anaesthetic technique in order to assess the efficacy of various doses of orally administered ondansetron in the prevention of postoperative nausea and vomiting. A total of 1257 patients were included in this analysis: 420 received oral formulations of placebo and 212, 296 and 329 received ondansetron 1, 8 and 16 mg, respectively. The following factors were measured in these studies and were considered to have a possible influence on the proportion of patients experiencing postoperative nausea and vomiting: age of patient; volatile anaesthetic; intraoperative dose of fentanyl; postoperative dose of morphine; country; anaesthesia duration; neuromuscular blocker; neuromuscular block antagonist; premedicant; recovery time; type of surgery; antiemetic treatment; body weight. Using a process of elimination based on logistic regression techniques, the factors found to be the most important influences on the frequencies of nausea and vomiting were antiemetic treatment, type of surgery, neuromuscular blocker, country, volatile anaesthetic and age. A statistically significant interaction between type of surgery and age was observed. Adjusted probabilities of nausea and vomiting were obtained from the model, including all the above factors, together with the type of surgery by age interaction. Ondansetron 8 mg showed the smallest adjusted probability of nausea (0.54) and vomiting (0.34) and placebo the greatest (nausea 0.75, vomiting 0.61). A similar pattern of adjusted probabilities over neuromuscular blocking agents was seen for nausea and vomiting, with the greatest occurring in patients receiving pancuronium (nausea 0.74, vomiting 0.57) and the least in patients receiving alcuronium (nausea 0.59, vomiting 0.38).(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Br J Anaesth

authors

Haigh CG,Kaplan LA,Durham JM,Dupeyron JP,Harmer M,Kenny GN

doi

10.1093/bja/71.4.517

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

517-22

issue

4

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)45644-3

journal_volume

71

pub_type

临床试验,杂志文章,meta分析,多中心研究,随机对照试验
  • Gastric and lower oesophageal sphincter (LOS) pressures in early pregnancy.

    abstract::Gastric (GP) and lower oesophageal sphincter pressures (LOSP) were measured in non-pregnant female volunteers (group I) and pregnant women with (group III) or without (group II) heartburn. Patients in early pregnancy had greater gastric pressures than group I. Mean barrier pressure (LOSP-GP) was significantly decrease...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/53.4.381

    authors: Brock-Utne JG,Dow TG,Dimopoulos GE,Welman S,Downing JW,Moshal MG

    更新日期:1981-04-01 00:00:00

  • Epidural analgesia in a child with sickle cell disease complicated by acute abdominal pain and priapism.

    abstract::We describe a case of a 9-yr-old child with sickle cell disease complicated by abdominal vaso-occlusive crisis and priapism. Both complications were successfully treated with a combination of epidural local anesthetics and morphine. ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/87.6.935

    authors: Labat F,Dubousset AM,Baujard C,Wasier AP,Benhamou D,Cucchiaro G

    更新日期:2001-12-01 00:00:00

  • Ventilation with low tidal volumes during upper abdominal surgery does not improve postoperative lung function.

    abstract:BACKGROUND:Prolonged postoperative decrease in lung function is common after major upper abdominal surgery. Evidence suggests that ventilation with low tidal volumes may limit the damage during mechanical ventilation. We compared postoperative lung function of patients undergoing upper abdominal surgery, mechanically v...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aes140

    authors: Treschan TA,Kaisers W,Schaefer MS,Bastin B,Schmalz U,Wania V,Eisenberger CF,Saleh A,Weiss M,Schmitz A,Kienbaum P,Sessler DI,Pannen B,Beiderlinden M

    更新日期:2012-08-01 00:00:00

  • Comparison of flumazenil with aminophylline to antagonize midazolam in elderly patients.

    abstract::We have compared, in a double-blind study, the efficacy of flumazenil with that of aminophylline in antagonizing the effects of midazolam in 60 patients (ASA I-II, mean age 66 yr) undergoing transurethral resection of prostate under spinal anaesthesia. All patients received midazolam 0.075 mg kg-1 i.v. and the test dr...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/66.5.591

    authors: Sibai AN,Sibai AM,Baraka A

    更新日期:1991-05-01 00:00:00

  • Prolonged brachial plexus block with 0.42% bupivacaine.

    abstract::A 55-yr-old man received a left supraclavicular brachial plexus block with 0.42% bupivacaine; he had profound motor and sensory block 26 h after injection; complete recovery occurred at 40 h. ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/63.5.604

    authors: Brockway MS,Winter AW,Wildsmith JA

    更新日期:1989-11-01 00:00:00

  • Peripheral nerve injury caused by injection needles used in regional anaesthesia: influence of bevel configuration, studied in a rat model.

    abstract::We have studied the immediate and long term (up to 28 days) effects of short and long bevelled needle impalement of the rat sciatic nerve. Three techniques were used to assess neural trauma and its consequences: stained longitudinal nerve sections were assessed by light microscopy and scored for injury; the extravasat...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/69.5.433

    authors: Rice AS,McMahon SB

    更新日期:1992-11-01 00:00:00

  • Effects of sevoflurane anaesthesia on radioligand binding to monoamine oxidase-B in vivo.

    abstract:BACKGROUND:The molecular actions underlying the clinical effects of inhaled anaesthetics such as sevoflurane and isoflurane are not fully understood. Unexpected observations in positron emission tomography (PET) studies with [11C]AZD9272, a metabotropic glutamate receptor 5 (mGluR5) radioligand with possible affinity f...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1016/j.bja.2020.08.052

    authors: Varnäs K,Finnema SJ,Johnström P,Arakawa R,Halldin C,Eriksson LI,Farde L

    更新日期:2021-01-01 00:00:00

  • Low-dose ketamine affects immune responses in humans during the early postoperative period.

    abstract:BACKGROUND:Anaesthesia and surgery are associated with impairment of the immune system expressed as an excessive proinflammatory immune response and suppression of cell-mediated immunity that may affect the course of the postoperative period. Addition of anaesthetic agents capable of attenuating the alterations in peri...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aem218

    authors: Beilin B,Rusabrov Y,Shapira Y,Roytblat L,Greemberg L,Yardeni IZ,Bessler H

    更新日期:2007-10-01 00:00:00

  • Comparison of high- and low-dose intrathecal morphine for spinal fusion in children.

    abstract:BACKGROUND:The purpose of this prospective study was to assess the blood-sparing effect, the quality of analgesia, and the incidence of side-effects of a low-dose regime of intrathecal opioids (ITO) when compared with those of a high-dose regime in scoliosis surgery in children. METHODS:Forty-six children were randoml...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aen025

    authors: Eschertzhuber S,Hohlrieder M,Keller C,Oswald E,Kuehbacher G,Innerhofer P

    更新日期:2008-04-01 00:00:00

  • Gaseous homeostasis and the circle system. Factors influencing anaesthetic gas exchange.

    abstract::A mathematical model of a subject breathing from a circle system has been used to follow the course of anaesthetic uptake during the simulated administration of 60% nitrous oxide, 2% halothane and 2% methoxyflurane, under non-rebreathing conditions and with fresh gas flows to the circle system of between 8 and 0.25 li...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/58.10.1167

    authors: Conway CM

    更新日期:1986-10-01 00:00:00

  • Retraction notice to "Monitoring of neuromuscular block after administration of vecuronium in patients with diabetes mellitus" [Br J Anaesth 2003; 90: 480-486].

    abstract::This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief of British Journal of Anaesthesia. The study is retracted for the following reasons: Statistical analysis suggests t...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,撤回出版物

    doi:10.1016/j.bja.2018.11.007

    authors: Saitoh Y,Kaneda K,Hattori H,Nakajima H,Murakawa M

    更新日期:2019-01-01 00:00:00

  • Knee-chest vs horizontal side position during induction of spinal anaesthesia in patients undergoing lumbar disc surgery.

    abstract::In the prone knee-chest position the spread of plain 0.5% bupivacaine in the cerebrospinal fluid and associated haemodynamic changes may be different compared with the horizontal position. A randomized comparison was performed in 40 ASA I-II patients, aged 24-61 yr, undergoing lumbar disc surgery. Subarachnoid injecti...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/79.5.609

    authors: Laakso E,Pitkänen M,Kyttä J,Rosenberg PH

    更新日期:1997-11-01 00:00:00

  • Emergence delirium or pain after anaesthesia--how to distinguish between the two in young children: a retrospective analysis of observational studies.

    abstract:BACKGROUND:Early postoperative negative behaviour in preschool children after general anaesthesia is a common problem. The distinction between emergence delirium (ED) and pain is difficult, but management differs between the two. The aim of the current analysis was to identify individual observational variables that ca...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aev552

    authors: Somaini M,Engelhardt T,Fumagalli R,Ingelmo PM

    更新日期:2016-03-01 00:00:00

  • Gram staining of protected pulmonary specimens in the early diagnosis of ventilator-associated pneumonia.

    abstract::We evaluated prospectively the use of Gram staining of protected pulmonary specimens to allow the early diagnosis of ventilator-associated pneumonia (VAP), compared with the use of 60 bronchoscopic protected specimen brushes (PSB) and 126 blinded plugged telescopic catheters (PTC) obtained from 134 patients. Gram stai...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/85.5.735

    authors: Mimoz O,Karim A,Mazoit JX,Edouard A,Leprince S,Nordmann P

    更新日期:2000-11-01 00:00:00

  • Difficult arterial cannulation in children: is a near-infrared vascular imaging system the answer?

    abstract:BACKGROUND:Arterial cannulation is a common anaesthetic procedure that can be challenging and time-consuming in small children. By visualizing the position of the radial artery, near-infrared vascular imaging systems (NIRVISs) might be of assistance in arterial cannulation. The present study evaluates the effectiveness...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aes193

    authors: Cuper NJ,de Graaff JC,Hartman BJ,Verdaasdonk RM,Kalkman CJ

    更新日期:2012-09-01 00:00:00

  • Capsaicin 8% patch for treprostinil subcutaneous infusion site pain in pulmonary hypertension patients.

    abstract:BACKGROUND:Treprostinil sodium improves haemodynamics and symptoms in pulmonary arterial hypertension (PAH) patients, but its subcutaneous (s.c.) administration can produce severe local site pain, and lead to discontinuation of vital treatment. Treprostinil is a prostacyclin analogue which stimulates prostacyclin recep...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/bja/aet308

    authors: Libri V,Gibbs JS,Pinato DJ,Iddamalgoda T,Khengar RH,Gin-Sing W,Huson L,Anand P

    更新日期:2014-02-01 00:00:00

  • Sedation following cardiac surgery: evaluation of alfentanil and morphine in the presence of a computerized closed loop arterial pressure controller.

    abstract::Forty patients who had undergone coronary artery graft surgery and who required vasodilator therapy for postoperative hypertension were given infusions of either alfentanil or morphine together with bolus doses of midazolam for sedation and analgesia while ventilation was controlled artificially. Sodium nitroprusside ...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/61.6.669

    authors: McMenemin IM,Church JA,Kenny GN

    更新日期:1988-12-01 00:00:00

  • Effect of age, gender and anaesthetic technique on the pharmacodynamics of atracurium.

    abstract::We have measured in 38 patients the plasma concentration profile of atracurium and its effect on the electromyographic first response of the train-of-four. One of three techniques was used to supplement anaesthesia with 66% nitrous oxide in oxygen, 0.9% isoflurane (end-tidal), 0.5% halothane (end-tidal) or midazolam 3...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1093/bja/70.1.38

    authors: Parker CJ,Hunter JM,Snowdon SL

    更新日期:1993-01-01 00:00:00

  • Use of di-isopropyl phenol as main agent for short procedures.

    abstract::The use of di-isopropyl phenol (Diprivan) for induction of anaesthesia was assessed in doses ranging from 1 to 3 mg kg-1. With less than 1.75mg kg-1 not all patients were anaesthetized; 2.0 mg kg-1 appeared to be a satisfactory induction dose. Involuntary muscle movement, cough and hiccup at induction were rare with a...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/53.11.1197

    authors: Briggs LP,Clarke RS,Dundee JW,Moore J,Bahar M,Wright PJ

    更新日期:1981-11-01 00:00:00

  • Postpartum cerebral ischaemia after accidental dural puncture and epidural blood patch.

    abstract::Puerperal women are reported to have a rate of cerebral infarction 13 times greater than non-pregnant females. We report a case of cerebral ischaemia in a 30-yr-old healthy parturient after epidural analgesia for labour, complicated by dural puncture treated with two epidural blood patches. Investigations showed the d...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:

    authors: Mercieri M,Mercieri A,Paolini S,Arcioni R,Lupoi D,Passarelli F,Pinto G,Celleno D

    更新日期:2003-01-01 00:00:00

  • Predictors and outcome impact of perioperative serum sodium changes in a high-risk population.

    abstract:BACKGROUND:The perioperative period may be associated with a marked neurohumoral stress response, significant fluid losses, and varied fluid replacement regimes. Acute changes in serum sodium concentration are therefore common, but predictors and outcomes of these changes have not been investigated in a large surgical ...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/aeu409

    authors: Klinck J,McNeill L,Di Angelantonio E,Menon DK

    更新日期:2015-04-01 00:00:00

  • Pattern of perioperative gabapentinoid use and risk for postoperative naloxone administration.

    abstract:BACKGROUND:Single preoperative gabapentinoid (gabapentin and pregabalin) administration has been associated with respiratory depression during Phase I anaesthesia recovery. In this study, we assess for associations between chronic (home) use and perioperative administration (preoperative and postoperative) of gabapenti...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1016/j.bja.2017.11.113

    authors: Deljou A,Hedrick SJ,Portner ER,Schroeder DR,Hooten WM,Sprung J,Weingarten TN

    更新日期:2018-04-01 00:00:00

  • Performing perioperative optimization of the high-risk surgical patient.

    abstract::Perioperative risk of death after general surgery is quoted as overall less than 1%. However, each individual's risk varies widely according to many identified factors with some having a significantly increased risk of a worse outcome. The observation that manipulating and targeting certain physiological parameters in...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1093/bja/ael102

    authors: Tote SP,Grounds RM

    更新日期:2006-07-01 00:00:00

  • Haemodynamic responses to antagonism of bocurarine block with atropine-neostigmine mixture in children.

    abstract::Following antagonism of tubocurarine block with a mixture of atropine 20 microgram/kg and neostigmine 50 microgram/kg in 20 children, heart rate decreased from a control value of 110.4 beat/min to 90.1 at 5 min and 89.2 at 6 min (P less than 0.02). Stroke volume index did not change during the first 5 min from a contr...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/49.9.901

    authors: Salem MR,Toyama T,Wong AY,Jacobs HK,Bennett EJ

    更新日期:1977-09-01 00:00:00

  • Measurement of lung volume by multiple indicator dilution. Differences in apparent volumes of distribution of oxygen, nitrogen and argon.

    abstract::A variant of a rebreathing/indicator-dilution technique was used to measure lung volume. Two or three indicators, which should have essentially the same pulmonary volume of distribution, were used. Gas compositions were measured by respiratory mass spectrometry and an extrapolation was used to allow for oxygen consump...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/56.3.289

    authors: Black AM,Hahn CE,Maynard P,Scott IL

    更新日期:1984-03-01 00:00:00

  • Comparison of chloral hydrate and midazolam by mouth as premedicants in children undergoing otolaryngological surgery.

    abstract::Chloral hydrate 25, 50 or 75 mg kg-1 or midazolam 0.4, 0.5 or 0.6 mg kg-1, all given by mouth in combination with atropine 0.03 mg kg-1, were compared as premedication in 248 children in a randomized, double-blind study. Chloral hydrate was significantly less palatable than midazolam. The anxiolytic effect of chloral ...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/61.4.390

    authors: Saarnivaara L,Lindgren L,Klemola UM

    更新日期:1988-10-01 00:00:00

  • Comparison of nitroglycerine, verapamil and nifedipine in the management of arterial pressure during coronary artery surgery.

    abstract::The efficacy of nitroglycerine, verapamil and nifedipine in controlling post-sternotomy hypertension was compared in four groups of 20 patients anaesthetized with fentanyl 100 micrograms kg-1 undergoing elective coronary artery surgery. Vasodilators were started before surgery and adjusted to maintain systolic arteria...

    journal_title:British journal of anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/bja/58.3.267

    authors: van Wezel HB,Bovill JG,Schuller J,Gielen J,Hoeneveld MH

    更新日期:1986-03-01 00:00:00

  • Troponin elevations after non-cardiac, non-vascular surgery are predictive of major adverse cardiac events and mortality: a systematic review and meta-analysis.

    abstract:BACKGROUND:Patients undergoing non-cardiac, non-vascular surgery are at risk of major cardiovascular complications. In non-cardiac surgery, troponin elevation has previously been shown to be an independent predictor of major adverse cardiac events and postoperative mortality; however, a majority of studies have focused...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/bja/aew321

    authors: Ekeloef S,Alamili M,Devereaux PJ,Gögenur I

    更新日期:2016-11-01 00:00:00

  • Preliminary evaluation of a new prototype laryngeal mask in children.

    abstract::We have assessed a prototype laryngeal mask airway (pLMA) in 50 anaesthetized children for ease of insertion, oropharyngeal leak pressures, gastric insufflation and fibreoptic position. The pLMA has a second smaller mask, which rests against the upper oesophageal sphincter, and a second cuff to increase the seal press...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1093/bja/82.1.132

    authors: Lopez-Gil M,Brimacombe J,Brain AI

    更新日期:1999-01-01 00:00:00

  • Inhibition of a tonic inhibitory conductance in mouse hippocampal neurones by negative allosteric modulators of α5 subunit-containing γ-aminobutyric acid type A receptors: implications for treating cognitive deficits.

    abstract:BACKGROUND:Multiple cognitive and psychiatric disorders are associated with an increased tonic inhibitory conductance that is generated by α5 subunit-containing γ-aminobutyric acid type A (α5 GABAA) receptors. Negative allosteric modulators that inhibit α5 GABAA receptors (α5-NAMs) are being developed as treatments for...

    journal_title:British journal of anaesthesia

    pub_type: 杂志文章

    doi:10.1016/j.bja.2020.11.032

    authors: Manzo MA,Wang DS,Li WW,Pinguelo A,Popa MO,Khodaei S,Atack JR,Ross RA,Orser BA

    更新日期:2020-12-30 00:00:00