Effect of age, gender and anaesthetic technique on the pharmacodynamics of atracurium.

Abstract:

:We have measured in 38 patients the plasma concentration profile of atracurium and its effect on the electromyographic first response of the train-of-four. One of three techniques was used to supplement anaesthesia with 66% nitrous oxide in oxygen, 0.9% isoflurane (end-tidal), 0.5% halothane (end-tidal) or midazolam 3-10 mg. A four-parameter threshold pharmacodynamic model was fitted to the data in each patient. Compared with a group of patients anaesthetized with an i.v. technique, the steady-state plasma concentration producing 50% block (Cpss50) was reduced by halothane, and to a greater extent by isoflurane. The rate constant for exit from the effect compartment (k(eo)) correlated negatively with age and was greater in female patients, but unaffected by anaesthetic technique. The values of gamma, the slope of the concentration-response curve, and of the threshold (Cpss theta) were not affected significantly by age, sex or anaesthetic technique.

journal_name

Br J Anaesth

authors

Parker CJ,Hunter JM,Snowdon SL

doi

10.1093/bja/70.1.38

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

38-41

issue

1

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)45911-3

journal_volume

70

pub_type

临床试验,杂志文章
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  • Bispectral Index asymmetry and COMFORT score in paediatric intensive care patients.

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