Comparison of flumazenil with aminophylline to antagonize midazolam in elderly patients.

Abstract:

:We have compared, in a double-blind study, the efficacy of flumazenil with that of aminophylline in antagonizing the effects of midazolam in 60 patients (ASA I-II, mean age 66 yr) undergoing transurethral resection of prostate under spinal anaesthesia. All patients received midazolam 0.075 mg kg-1 i.v. and the test drugs were given 5 min after its administration. Patients were allocated randomly to receive i.v. flumazenil 0.01 mg kg-1, aminophylline 2 mg kg-1 or placebo saline 0.1 ml kg-1. One minute after administration, aminophylline caused 42% reversal of sedation, 66% of disorientation and 73% of lack of co-operation in comparison with placebo, although there was marked individual variation. Flumazenil caused complete and rapid antagonism of sedation, disorientation and lack of cooperation.

journal_name

Br J Anaesth

authors

Sibai AN,Sibai AM,Baraka A

doi

10.1093/bja/66.5.591

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

591-5

issue

5

eissn

0007-0912

issn

1471-6771

pii

S0007-0912(17)48110-4

journal_volume

66

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 临床试验,杂志文章,随机对照试验

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    doi:10.1093/bja/49.12.1239

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    pub_type: 杂志文章,随机对照试验

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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