Abstract：
:Riluzole modulates several transmitter systems which may be involved in nociception. Antinociceptive effects have been shown in animal studies, but there are no human data. Therefore, we have examined the acute analgesic effect of riluzole in a human model of inflammatory pain induced by a thermal injury on the distal leg (47 degrees C, 7 min, 12.5 cm2) in 20 healthy volunteers. Hyperalgesia to mechanical and heat stimuli were examined by von Frey hairs and thermodes. We used a randomized, double-blind, placebo-controlled design, and subjects received riluzole 100 mg or placebo for 2 days with a 14-day interval. The burns produced significant hyperalgesia, but riluzole had no acute analgesic effects in normal or hyperalgesic skin.
journal_name
Br J Anaesthjournal_title
British journal of anaesthesiaauthors
Hammer NA,Lillesø J,Pedersen JL,Kehlet Hdoi
10.1093/bja/82.5.718subject
Has Abstractpub_date
1999-05-01 00:00:00pages
718-22issue
5eissn
0007-0912issn
1471-6771pii
S0007-0912(17)38529-Xjournal_volume
82pub_type
临床试验,杂志文章,随机对照试验abstract：:Postoperative management following major surgery in patients with neuromuscular disorders associated with scoliosis is frequently complicated by sputum retention and ventilatory failure. This report demonstrates the successful perioperative management of an 11-yr-old boy with type II spinal muscular atrophy undergoing...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aef227
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND:We used an automated bispectral index (BIS)-guided dual-loop controller to determine propofol and remifentanil requirements during general anaesthesia in obese and lean surgical patients. METHODS:Obese patients, BMI>35 kg m(-2), and lean patients (<25 kg m(-2)) having laparoscopic procedures were prospectiv...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1093/bja/aeu401
更新日期：2015-04-01 00:00:00
abstract：:Cholinesterase phenotyping studies have been carried out in two laboratories on blood specimens from 28 patients shown to be susceptible to malignant hyperpyrexia. In contrast to previously published reports, no evidence could be found for an increase in the frequency of the E1u E1f genotype above that known to occur ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/53.3.245
更新日期：1981-03-01 00:00:00
abstract：:A variant of a rebreathing/indicator-dilution technique was used to measure lung volume. Two or three indicators, which should have essentially the same pulmonary volume of distribution, were used. Gas compositions were measured by respiratory mass spectrometry and an extrapolation was used to allow for oxygen consump...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/56.3.289
更新日期：1984-03-01 00:00:00
abstract：:The serum vasopressin (S-AVP) concentration, serum sodium concentration and osmolality, central venous pressure and fluid balance were measured during 10-min periods in 32 patients undergoing transurethral resection of the prostate. Concentration of S-AVP was unaffected by uncomplicated resection; irrigant absorption ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/63.3.330
更新日期：1989-09-01 00:00:00
abstract：BACKGROUND:The current prevalence of healthcare-associated infections (HCAIs) is a major public health concern. Patient contact in the operating theatre (OT) can contribute to HCAI via microbial contamination. The application of hand hygiene is effective in reducing infection rates. Limited data are available on adhere...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aer162
更新日期：2011-10-01 00:00:00
abstract：:Muscle biopsy and in vitro contracture tests for diagnosis of susceptibility to malignant hyperthermia (MH) were performed in two patients who had developed fever and severe myolysis during exercise. MH susceptibility was confirmed in one patient, but in the other, exercise-induced heat stroke proved to be the correct...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/66.1.138
更新日期：1991-01-01 00:00:00
abstract：:We describe the anaesthetic management of a patient who underwent transthoracic endoscopic vagotomy. One-lung ventilation was necessary to provide adequate surgical access. Potential intraoperative problems involved arterial oxygen saturation during one-lung ventilation, unequal intrathoracic pressures causing mediast...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/68.3.318
更新日期：1992-03-01 00:00:00
abstract：:One hundred and forty male rats received a cryoinjury to a segment of the exposed sciatic nerve. A variety of temperatures and freeze patterns was used and the recovery of function was monitored. Where obvious nerve freezing occurred, the cryoinjury caused complete loss of function in the limb. The return of motor act...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/53.11.1121
更新日期：1981-11-01 00:00:00
abstract：:Plasma concentrations of pancuronium were measured using a fluorimetric method in six patients with normal renal function and seven patients in chronic renal failure. A tow-compartment open model was used in the pharmacokinetic analysis of the data. With this model, the clearance of pancuronium was found to be reduce...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/48.4.341
更新日期：1976-04-01 00:00:00
abstract：INTRODUCTION:Current guidelines suggest a fasting time of 2 h for clear fluids, which is often exceeded in clinical practice, leading to discomfort, dehydration and stressful anaesthesia induction to patients, especially in the paediatric population. Shorter fluid fasting might be a strategy to improve patient comfort ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aeu399
更新日期：2015-03-01 00:00:00
abstract：:Thiopental is a racemate of equimolar R- and S-thiopental enantiomers that have different potencies in laboratory experiments. We measured concentrations of R- and S-thiopental in plasma, tissues and brain microdialysate of rats after computer-controlled infusion of thiopental i.v. to a plasma concentration of 40 micr...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/oxfordjournals.bja.a013385
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Recent investigations showed that isoflurane can induce pharmacological preconditioning. The present study aimed to compare the potency of four different halogenated anaesthetics to induce preconditioning. METHODS:Anaesthetized open-chest rabbits underwent 30 min of coronary artery occlusion followed by 3 h...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：:Intraoperative awareness, with or without recall, continues to be a topic of clinical significance and neurobiological interest. In this article, we review evidence pertaining to the incidence, sequelae, and prevention of intraoperative awareness. We also assess which aspects of the complication are well understood (i...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,评审
doi：10.1093/bja/aev034
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:The role of repeated prone positioning in intubated subjects with acute respiratory distress syndrome caused by COVID-19 remains unclear. METHODS:We conducted a retrospective observational cohort study of critically ill intubated patients with COVID-19 who were placed in the prone position between March 18,...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2020.09.042
更新日期：2021-01-01 00:00:00
abstract：:Changes in intragastric pressure after the administration of suxamethonium 1.5 mg kg-1 i.v. were studied in 32 children (mean age 6.9 yr) pretreated with either physiological saline or alfentanil 50 micrograms kg-1. Anaesthesia was induced with thiopentone 5 mg kg-1. The incidence and intensity of muscle fasciculation...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/60.2.176
更新日期：1988-02-01 00:00:00
abstract：BACKGROUND:The posterolateral and medial aspect of the arm is supplied by the axillary (AXN) and intercostobrachial nerves (ICBN), which are not anaesthetised by an axillary brachial plexus block (ABPB). Blockade of the AXN and the ICBN has been reported in the quadrangular space (QS) posteriorly or by serratus plane b...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1016/j.bja.2018.06.006
更新日期：2018-10-01 00:00:00
abstract：:The 119 patients who had undergone previous Caesarean section lumbar extradural block was administered to 77 (65%); the other 42 (35%) received analgesia with ketobemidone 0.8-1.0 ml i.m. or nitrous oxide in oxygen intermittently, or both. Controlled i.v. infusion of oxytocin for induction or acceleration of labour wa...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/52.8.827
更新日期：1980-08-01 00:00:00
abstract：BACKGROUND:Low-dose droperidol is suggested to be cost-effective in preventing nausea and vomiting after ambulatory surgery. This clinical study evaluated patient postural stability using a computerized force platform after an i.v. dose of droperidol 0.625 mg in outpatients undergoing gynaecological dilatation and cure...
journal_title：British journal of anaesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/bja/88.6.819
更新日期：2002-06-01 00:00:00
abstract：BACKGROUND:Handover of anaesthesia patient care during surgery is common; however, its association with patient outcome is unclear. This systematic review aimed to assess the impact of anaesthesia handover during surgery on patient outcome. METHODS:All prospective and retrospective clinical studies specifically invest...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,meta分析
doi：10.1016/j.bja.2020.05.062
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:The low and moderate doses of dexmedetomidine reduce arterial pressure and heart rate (HR), suggesting attenuation of sympathetic activity and dominance of cardiac-vagal activity. These autonomic responses under dexmedetomidine sedation may attenuate cardiovascular reflex responses to temporal reduction in a...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/aep210
更新日期：2009-10-01 00:00:00
abstract：:A case of an infant receiving orthotopic heart transplantation with over-sized donor heart was reported. Left lower pulmonary venous obstruction after sternotomy closure was detected by transoesophageal echocardiography (TOE) and the decision to delay sternal closure was made and the clinical outcome was very satisfac...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/88.4.590
更新日期：2002-04-01 00:00:00
abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief, Professor Hugh Hemmings, based on the recommendations of Justus-Liebig-University Giessen f...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,撤回出版物
doi：10.1016/j.bja.2020.07.036
更新日期：2020-09-01 00:00:00
abstract：:The aim of this study was to find, using modern techniques, any histological differences in muscle biopsies between malignant hyperthermia (MH) susceptible (MHS), MH equivocal (MHE) and MH negative (MHN) patients. On the basis of the European MH contracture test carried out in 83 patients, 23 were shown to be MHS, nin...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/79.3.327
更新日期：1997-09-01 00:00:00
abstract：:We have investigated the effects of 9.5% and 14.1% MAC concentrations of isoflurane on some psychometric measurements. Both concentrations depressed peak saccadic velocity (P < 0.01), choice reaction time (P < 0.05) and visual analogue scores for sedation (P < 0.05), but not the critical flicker fusion threshold. The ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/71.6.839
更新日期：1993-12-01 00:00:00
abstract：BACKGROUND:The aim of this study is to test the hypothesis that a standard 30-min break in a routine 7.5 h period of work makes a difference in cognitive function. METHODS:In a double-blinded, cross-over trial 30 residents in anaesthesia were randomized to receive or not to receive a 30-min break between the assessmen...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1093/bja/ael151
更新日期：2006-09-01 00:00:00
abstract：BACKGROUND:Ivabradine lowers heart rate (HR) without affecting contractility or vascular tone. It is licensed for HR control in chronic heart diseases. We performed a systematic review and meta-analyses to examine whether ivabradine could decrease major adverse cardiovascular events (MACE) and mortality in critically i...
journal_title：British journal of anaesthesia
pub_type： 杂志文章,meta分析
doi：10.1016/j.bja.2020.01.027
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:The memory effect of dexmedetomidine has not been prospectively evaluated in children. We evaluated the feasibility of measuring memory and sedation responses in children during dexmedetomidine sedation for non-painful radiological imaging studies. Secondarily, we quantified changes in memory in relation to ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aew421
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:Plasma-free volume replacement in haemorrhage often results in dilutional coagulopathy. Prothrombin time index (PTI) and activated partial thromboplastin time (aPTT) are used for monitoring haemostasis but have not yet been clinically evaluated. Our aim was to investigate the effects of haemodilution on the ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aeq199
更新日期：2010-10-01 00:00:00
abstract：BACKGROUND:Myocardial potassium channels are complexes formed by different subunits. The subunit composition may influence the cardiotoxic action of local anaesthetics. The effects of amide local anaesthetics on HERG channels co-expressed with the putative subunit MiRP1 have not been established. It is also unclear if ...
journal_title：British journal of anaesthesia
pub_type： 杂志文章
doi：10.1093/bja/aeh026
更新日期：2004-01-01 00:00:00
